Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 6

System / cell line: gfp+ ✕ Assay: organoid ✕ Clear

Spatially resolved osteoblast-traced transcriptomics uncovers TGF-β as a combination target with sclerostin in osteoporosis.

PMID 41927532 · PMC13046724 · Bone research · 2026 · 8 claims · 8 setups

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Spatially resolved osteoblast-traced transcriptomics (lineage tracing + SLACS) identifies TGF-β signaling as a regulator of osteoblast activation state on quiescent bone surfaces

dmp1-creert2 gfp+ spatial mc3t3-e1 spatially cell-type gsea
Uropathogenic Escherichia coli invade luminal prostate cells via FimH-PPAP receptor binding.

PMID 41507584 · PMC12872464 · Nature microbiology · 2026 · 8 claims · 8 setups

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A 2D mouse stem cell-derived prostate epithelial organoid model was developed that mimics epithelial heterogeneity of the murine prostate

prostate bladder immunofluorescence single-cell transepithelial
Glioblastoma invasion into different organoid hosts reveals cell-intrinsic and proliferative migratory programs.

PMID 41959666 · PMC13059114 · iScience · 2026 · 8 claims · 8 setups

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GB cells invade both neural and endodermal organoid hosts (lineage-independent), whereas non-malignant neural progenitor cells show markedly reduced infiltration

gbm1 gfp-gbm1 facs-sorted post-invasion image-based immunofluorescence single-cell
De novo H3.3K27M-altered diffuse midline glioma in human brainstem organoids to dissect GD2 CAR T cell function.

PMID 41492091 · PMC12948678 · Nature cancer · 2026 · 8 claims · 8 setups

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FGF4 supplementation during organoid patterning specifically induces pontine/rostral hindbrain brainstem identity

hes brainstem day developing bulk immunofluorescence scrna-seq
Keratin 5 marks cancer-propagating cells sustained by an osteopontin-producing niche in high-grade serous ovarian carcinoma.

PMID 42111394 · PMC13155427 · Cancer heterogeneity and plasticity · 2026 · 8 claims · 8 setups

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KRT5+ cells represent bona fide cancer-propagating cells (CPCs) in HGSC

hgsc skov3 facs-sorted nod immunohistochemistry lentiviral organoid
Patient-derived orthotopic xenograft models recapitulate the peritoneal dissemination of pancreatic cancer and delineate its transcriptional and regulatory programs.

PMID 41673768 · PMC12998334 · Journal of experimental & clinical cancer research : CR · 2026 · 6 claims · 8 setups

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Organoids derived from malignant effusions of PDAC patients reproducibly generate peritoneal metastases after orthotopic implantation into the pancreas of immunodeficient mice

pdac organoids frozen pdox orthotopic single-nucleus single-cell

Experiments

Spatially resolved osteoblast-traced transcriptomics uncovers TGF-β as a combination target with sclerostin in osteoporosis.

Uropathogenic Escherichia coli invade luminal prostate cells via FimH-PPAP receptor binding.

Glioblastoma invasion into different organoid hosts reveals cell-intrinsic and proliferative migratory programs.

De novo H3.3K27M-altered diffuse midline glioma in human brainstem organoids to dissect GD2 CAR T cell function.

Keratin 5 marks cancer-propagating cells sustained by an osteopontin-producing niche in high-grade serous ovarian carcinoma.

Patient-derived orthotopic xenograft models recapitulate the peritoneal dissemination of pancreatic cancer and delineate its transcriptional and regulatory programs.