Experiments
Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).
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A simple and robust method for connecting small-molecule drugs using gene-expression signatures.
PMID 18518950 · PMC2464610 · BMC bioinformatics · 2008 · 8 claims · 4 setups
A new method for building reference gene-expression profiles and scoring/testing connections improves on the original Connectivity Map by enabling statistical significance testing of connections.
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The use of edge-betweenness clustering to investigate biological function in protein interaction networks.
PMID 15740614 · PMC555937 · BMC bioinformatics · 2005 · 8 claims · 7 setups
Edge-Betweenness clustering separates protein interaction graphs into subgraphs whose GO term distributions show significant correlations, revealing biologically meaningful functional modules.
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Allelic drop-out may occur with a primer binding site polymorphism for the commonly used RFLP assay for the -1131T>C polymorphism of the Apolipoprotein AV gene.
PMID 16670016 · PMC1513378 · Lipids in health and disease · 2006 · 8 claims · 6 setups
A -987C>T polymorphism located 4bp from the 3' end of the MseI RFLP forward primer causes allelic drop-out, producing incorrect -1131T>C genotypes.
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Towards alignment independent quantitative assessment of homology detection.
PMID 17205117 · PMC1762415 · PloS one · 2006 · 8 claims · 6 setups
The Fhom Estimator uses the prevalence of a conserved protein feature (X) in two protein sets to estimate the fraction of true homologs among paired proteins, independent of alignment quality.