Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• ROR1-PI3K/AKT signaling drives adaptive resistance to cell cycle blockade in TP53 mutated ovarian cancer.

  PMID 41748546 · PMC13004963 · Cell death & disease · 2026 · 7 claims · 8 setups

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  A shared PI3K/AKT-regulated signaling node governs drug adaptation across all long-term resistant (lt-res) ADA and PTX models

  hgsoc kuramochi jhos2 parental long-term inducible overexpression

• Identification of RNA-Binding Protein Targets with HyperTRIBE in Saccharomyces cerevisiae.

  PMID 37240377 · PMC10218906 · International journal of molecular sciences · 2023 · 7 claims · 8 setups

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  HyperTRIBE was successfully established in S. cerevisiae by fusing an RBP to the hyper-active catalytic domain of human ADAR2 (E488Q), marking target transcripts with A-to-G editing events detectable by high-throughput sequencing

  cerevisiae khd1 wild-type bfr1-heterozygous hypertribe western meme

• The emergence of multiple testicular cell lineages in human stem cell-derived testis-like organoids.

  PMID 41725354 · PMC12989076 · Development (Cambridge, England) · 2026 · 7 claims · 5 setups

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  hiPSC-derived testis-like organoids show significant transcriptional shifts from pluripotency toward gonadal/testicular gene expression compared to undifferentiated stem cells

  hipscs day degs testis-like bulk single-cell term

• Catalytic activity of KMT5B promotes ciliogenesis without affecting global chromatin accessibility.

  PMID 41946567 · PMC13057974 · Life science alliance · 2026 · 8 claims · 7 setups

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  Single knockdown of KMT5B, but not KMT5C, causes ciliogenic phenotypic defects (fewer/shorter cilia, depleted actin cap, occasionally clumped basal bodies)

  xenopus whole-mount bulk term

• Rapid identification of PAX2/5/8 direct downstream targets in the otic vesicle by combinatorial use of bioinformatics tools.

  PMID 18828907 · PMC2760872 · Genome biology · 2008 · 8 claims · 8 setups

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  A combinatorial bioinformatics pipeline (evolutionary double filtering comparative genomics, GXD/ZFIN database queries, MEDLINE text mining) can rapidly and specifically identify PAX2/5/8 direct downstream targets in the otic vesicle

  genome candidate gxd medline evolutionary gene expression

• Combining transcriptional profiling and genetic linkage analysis to uncover gene networks operating in hematopoietic stem cells and their progeny.

  PMID 18560825 · PMC2493868 · Immunogenetics · 2008 · 8 claims · 8 setups

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  Neither transcriptional profiling alone nor genetic linkage analysis alone has been an effective approach to identify genes or gene networks that specify stemness or initiate differentiation/lineage specification.

  escs fibroblasts hematopoietic bxd transcriptional forced long-term

• GLYATL1 is associated with metabolic and epigenetic changes and with endocrine resistance in luminal breast cancer.

  PMID 42050691 · PMC13126711 · Clinical epigenetics · 2026 · 8 claims · 8 setups

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  GLYATL1 expression is upregulated in AI-resistant breast cancer cell models and in patients undergoing AI therapy

  mcf7 lysates rna-sequencing atac-sequencing epic

• In vivo single-cell RNA metabolic labeling resolves early transcriptional responders in the regenerating zebrafish heart.

  PMID 42086590 · PMC13144409 · Nature communications · 2026 · 8 claims · 5 setups

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  SLAM-seq (4sU metabolic labeling with T-to-C conversion detection) can be established and quantified in the adult zebrafish heart at the bulk level

  zebrafish macrophage-like bulk scslam-seq pathway

• Single-nucleus mRNA-sequencing reveals dynamics of lipogenic and thermogenic adipocyte populations in murine brown adipose tissue in response to cold exposure.

  PMID 40945691 · PMC12506565 · Molecular metabolism · 2025 · 8 claims · 8 setups

  Has reproduction · 93

  snRNA-seq of murine BAT identifies seven distinct brown adipocyte subtypes with distinct metabolic profiles, part of a 21-cell-type atlas.

  interscapular ibat bat single-nucleus qpcr western

• Genome-wide location analysis and expression studies reveal a role for p110 CUX1 in the activation of DNA replication genes.

  PMID 18003658 · PMC2248751 · Nucleic acids research · 2008 · 8 claims · 8 setups

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  p110 CUX1 is recruited to promoters of cell cycle-related target genes preferentially during S phase

  hela hs578t nih3t3 genomic chap-chip conventional scanning

• The ubiquitin ligase KLHL6 drives resistance to CD8(+) T cell dysfunction.

  PMID 41535474 · PMC12979199 · Nature · 2026 · 8 claims · 8 setups

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  KLHL6 is a dual-negative regulator of both T cell exhaustion and mitochondrial dysfunction

  cd8+ cas9+ sgklhl6-transduced klhl6 bulk pooled flow

• Single-cell and isoform-specific translational profiling of the mouse brain.

  PMID 41708856 · PMC13102718 · Nature · 2026 · 8 claims · 8 setups

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  Ribo-STAMP coupled with short-read and long-read single-cell RNA-seq enables isoform-sensitive single-cell translatome profiling in the brain

  cortical curated hippocampus bulk immunocytochemistry eclip

• Synaptic dysfunction and oxidative stress in Alzheimer's disease: emerging mechanisms.

  PMID 16989739 · PMC3933161 · Journal of cellular and molecular medicine · 2006 · 6 claims · 8 setups

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  Mutations in APP, PS1 and PS2 genes and polymorphisms in the APOE gene are implicated in AD pathogenesis

  alzheimer brain alzheimer's presenilin-1 microarray proteomic transgenic