Experiments
Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).
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Has reproduction · 71
Single-Cell Transcriptomic Landscape of Right-Sided Colon Cancer Reveals Cellular and Molecular Features of Metastatic Potential.
PMID 41898210 · PMC13024220 · Biomedicines · 2026 · 8 claims · 8 setups
Liver metastatic potential in RCC is marked by stem-like tumor states, metabolic plasticity, and microenvironmental remodeling.
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Has reproduction
Comprehensive analysis of m(6)A methylome alterations after azacytidine plus venetoclax treatment for acute myeloid leukemia by nanopore sequencing.
PMID 38510975 · PMC10950754 · Computational and structural biotechnology journal · 2024 · 8 claims · 6 setups
m6A site number and m6A levels are significantly lower in post-treatment complete remission (CR) bone marrow than in pre-treatment AML bone marrow
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Focused glycomic analysis of the N-linked glycan biosynthetic pathway in ovarian cancer.
PMID 18690643 · PMC3970323 · Proteomics · 2008 · 8 claims · 5 setups
N-linked glycan biosynthetic enzyme transcript profiles in normal mouse and human ovarian tissue are similar, indicating species conservation
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Has reproduction · 69
Clinical and molecular correlation defines activity of physiological pathways in life-sustaining kidney xenotransplantation.
PMID 37311769 · PMC10264453 · Nature communications · 2023 · 7 claims · 8 setups
Porcine kidney xenografts transplanted into NHPs show only modest growth over time.
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Has reproduction · 54
Gene-Expression Profiling Suggests Impaired Signaling via the Interferon Pathway in Cstb-/- Microglia.
PMID 27355630 · PMC4927094 · PloS one · 2016 · 8 claims · 8 setups
In Cstb-/- microglia, 184 genes were differentially expressed relative to control, of which 33 were identified by both microarray and RNA-seq.
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Has reproduction · 71
Harnessing secretory pathway differences between HEK293 and CHO to rescue production of difficult to express proteins.
PMID 35301123 · PMC9189052 · Metabolic engineering · 2022 · 8 claims · 7 setups
Swapping expression host from CHO to HEK293 improves secreted titers for roughly one third of difficult-to-express human proteins
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Has reproduction · 61
Unraveling the role of bacteria with heritable versus non-heritable relative abundance in the gut on boar semen quality.
PMID 41199168 · PMC12590650 · Genetics, selection, evolution : GSE · 2025 · 6 claims · 7 setups
39 heritable and 91 non-heritable bacterial genera were identified in the boar gut based on heritability of relative abundance
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Has reproduction · 50
GAL08, an Uncultivated Group of Acidobacteria, Is a Dominant Bacterial Clade in a Neutral Hot Spring.
PMID 35087491 · PMC8787282 · Frontiers in microbiology · 2021 · 8 claims · 8 setups
GAL08 is a dominant bacterial clade in a neutral hot spring, comprising up to 29.2% of the community by relative read abundance and up to 4.7 × 10^5 16S rRNA gene copies per gram sediment.
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Expression profiling of drug response--from genes to pathways.
PMID 17117610 · PMC3181826 · Dialogues in clinical neuroscience · 2006 · 8 claims · 8 setups
Understanding individual response to a drug (efficacy/tolerability) is the major bottleneck in current drug development and clinical trials.
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A network model for the correlation between epistasis and genomic complexity.
PMID 18648534 · PMC2481279 · PloS one · 2008 · 8 claims · 5 setups
In small networks with multifunctional nodes, lack of redundancy, and absence of alternative pathways, epistasis is antagonistic on average.
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Flux balance analysis of mycolic acid pathway: targets for anti-tubercular drugs.
PMID 16261191 · PMC1246807 · PLoS computational biology · 2005 · 7 claims · 7 setups
A comprehensive stoichiometric model of the MAP was built comprising 197 metabolites, 219 reactions, and 28 proteins
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Has reproduction · 75
Identification and analysis of genes associated with epithelial ovarian cancer by integrated bioinformatics methods.
PMID 34143800 · PMC8213194 · PloS one · 2021 · 7 claims · 6 setups
306 overlapping DEGs (265 up-regulated, 41 down-regulated) were identified across three independent GEO datasets in EOC vs normal ovarian tissue.
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Has reproduction · 66
Caloric Restriction Reprograms Adipose Tissues in Rhesus Monkeys.
PMID 41042069 · PMC12686577 · Aging cell · 2025 · 8 claims · 8 setups
At baseline, SAT and VAT transcriptomes are highly similar, with only ~1% of genes (30 genes, adjusted p<0.05) differentially expressed between depots in Controls
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Indirect genomic effects on survival from gene expression data.
PMID 18358079 · PMC2397510 · Genome biology · 2008 · 7 claims · 6 setups
A novel methodology (dynamic path analysis combined with additive hazard survival regression) can detect and quantify indirect effects of gene expression on survival mediated through transcription factor target genes.
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Quantitative proteomics analysis of maternal plasma in Down syndrome pregnancies using isobaric tagging reagent (iTRAQ).
PMID 19902006 · PMC2774473 · Journal of biomedicine & biotechnology · 2010 · 8 claims · 5 setups
iTRAQ labelling combined with 4800 MALDI TOF/TOF can detect quantitative differences in the maternal plasma proteome between DS and euploid pregnancies
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Has reproduction · 100
Generic injuries are sufficient to induce ectopic Wnt organizers in Hydra.
PMID 33779545 · PMC8049744 · eLife · 2021 · 8 claims · 6 setups
The initial transcriptional and chromatin response to mid-gastric bisection is identical at oral and aboral wounds at 3 hpa and only diverges by 8 hpa.
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Has reproduction · 73
A gene signature related to programmed cell death to predict immunotherapy response and prognosis in colon adenocarcinoma.
PMID 39950044 · PMC11823652 · PeerJ · 2025 · 8 claims · 8 setups
COAD patients can be divided into two molecular subtypes (S1, S2) based on 21 prognostic PCD-related genes, with S1 showing worse prognosis and immunosuppressive microenvironment, S2 showing better prognosis and stronger anti-tumor immunity
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Has reproduction · 80
Transcriptome-Proteome Profiling in Burkholderia thailandensis during the Transition from Exponential to Stationary Phase.
PMID 40680064 · PMC12322963 · Journal of proteome research · 2025 · 8 claims · 7 setups
928 differentially accumulating mRNAs (564 up, 364 down) were identified between exponential and stationary phase
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Has reproduction · 68
Targeting the epigenome and the integrated stress response to normalize colorectal cancer subclonal plasticity and progression.
PMID 41963303 · PMC13181133 · Cell death & disease · 2026 · 7 claims · 8 setups
The integrated stress response induces colorectal cancer cell plasticity, subclonal diversity, and tumor progression in stress-surviving cells
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Has reproduction · 77
Electroacupuncture reshapes the microbial co-occurrence networks related to the behavioral and psychological symptoms of dementia in Alzheimer's disease.
PMID 41676443 · PMC12806058 · iMetaOmics · 2025 · 6 claims · 7 setups
Electroacupuncture reshapes microbial co-occurrence network topology and drives keystone species in AD-related BPSD, with R. gnavus emerging as a likely keystone species post-intervention.