Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Prediction of prognostic signatures in triple-negative breast cancer based on the differential expression analysis via NanoString nCounter immune panel.

  PMID 33138797 · PMC7607642 · BMC cancer · 2020 · 8 claims · 8 setups

  Has reproduction · 72

  edgeR-based DEG selection is more appropriate for feature selection than Elastic Net when sample sizes are small.

  ffpe same nanostring tnbc nanostring immunohistochemistry differential

• NUSAP1 Could be a Potential Target for Preventing NAFLD Progression to Liver Cancer.

  PMID 35431924 · PMC9010788 · Frontiers in pharmacology · 2022 · 7 claims · 8 setups

  Has reproduction · 45

  NUSAP1 is a hub gene linking NAFLD fibrosis progression and NAFLD-associated HCC

  liver common hl-7702 c57bl deg kegg rt-pcr

• SPRR1B+ keratinocytes prime oral mucosa for rapid wound healing via STAT3 activation.

  PMID 39300285 · PMC11413210 · Communications biology · 2024 · 8 claims · 8 setups

  Has reproduction · 78

  A shared wound healing gene set (P2-WHGs, 146 genes) is constitutively expressed in uninjured oral mucosa but not in uninjured skin

  injured normal p2-whgs oral bulk single-cell gene

• Identification and validation of a metabolic-related gene risk model predicting the prognosis of lung, colon, and breast cancers.

  PMID 39779736 · PMC11711664 · Scientific reports · 2025 · 8 claims · 8 setups

  Has reproduction · 74

  540 DEGs overlap across breast, colorectal, and lung cancers out of 11,384 DEGs analyzed

  breast colorectal lung common microarray kegg protein-protein

• Comprehensive bioinformatics analysis and experimental verification identify mitochondrial gene Dgat2 as a novel therapeutic biomarker for myocardial ischemia-reperfusion.

  PMID 40510478 · PMC12159077 · Frontiers in endocrinology · 2025 · 8 claims · 8 setups

  Has reproduction · 64

  Dgat2 is a hub mitochondria-related differentially expressed gene (MitoDEG) that can serve as a novel biomarker and therapeutic target in MI/RI

  heart degs dgat2 mitodegs microarray kegg protein-protein

• Screening of Diagnostic Biomarkers and Immune Infiltration Characteristics Linking Rheumatoid Arthritis and Rosacea Based on Bioinformatics Analysis.

  PMID 39104909 · PMC11299729 · Journal of inflammation research · 2024 · 8 claims · 8 setups

  Has reproduction · 48

  277 co-expressed DEGs shared between RA and rosacea are enriched in immune processes and chemokine-mediated signaling pathways

  synovial rosacea co-expressed serum microarray weighted protein-protein

• CASK loss of function differentially regulates neuronal maturation and synaptic function in human induced cortical excitatory neurons.

  PMID 36262316 · PMC9574418 · iScience · 2022 · 7 claims · 8 setups

  Has reproduction · 62

  Immature (day 7) CASK KO induced neurons show increased dendritic complexity/neurite overgrowth and upregulated gene networks for cell adhesion, neurite outgrowth, and cytoskeletal organization.

  day mature bulk qrt-pcr gene

• Oxidative stress-associated genes TPPP3 and VEGFA in COPD revealed by bulk and single-cell sequencing analysis.

  PMID 41620539 · PMC12916760 · Scientific reports · 2026 · 8 claims · 9 setups

  Full-text index only

  76 overlapping genes were identified between COPD-associated DEGs and oxidative stress-related genes.

  lung genecards differentially bronchial bulk database functional

• A tissue-resolved, network-based transcriptomic framework for abiotic stress responses in sorghum.

  PMID 41904985 · PMC13033392 · The Plant journal : for cell and molecular biology · 2026 · 8 claims · 8 setups

  Full-text index only

  Tissue specificity is the dominant determinant of abiotic stress-induced gene reprogramming across drought, heat, and salinity stress in sorghum

  sorghum rna-seq qrt-pcr wgcna

• Identification of markers correlating with mitochondrial function in myocardial infarction by bioinformatics.

  PMID 39775580 · PMC11684664 · PloS one · 2024 · 7 claims · 8 setups

  Full-text index only

  MitoDEGs in MI are mainly involved in mitochondrial function and ATP synthesis pathways

  left mus combined heart microarray weighted bulk

• Transcriptomic insights into thermal manipulation and heat stress in skeletal muscles of broiler chickens.

  PMID 41905070 · PMC13054079 · Poultry science · 2026 · 6 claims · 5 setups

  Full-text index only

  Acute HS induces pronounced transcriptional changes including activation of immune signaling and stress-responsive pathways and suppression of metabolic/energy-related processes

  pectoralis broiler muscle bulk qrt-pcr body

• Integration of multi-omics and machine learning strategies identifies immune related candidate biomarkers in inflammation-associated hypertrophic cardiomyopathy.

  PMID 41080564 · PMC12510942 · Frontiers in immunology · 2025 · 8 claims · 8 setups

  Has reproduction · 85

  Seven key immune-related genes (RNF165, SNCA, SRGN, MARCO, STEAP4, SIGLEC9, TKT) are associated with HCM by intersecting DEGs with MR-identified eQTLs

  left eqtl degs merged bulk two-sample functional

• Gene-Expression Profiling Suggests Impaired Signaling via the Interferon Pathway in Cstb-/- Microglia.

  PMID 27355630 · PMC4927094 · PloS one · 2016 · 8 claims · 8 setups

  Has reproduction · 54

  In Cstb-/- microglia, 184 genes were differentially expressed relative to control, of which 33 were identified by both microarray and RNA-seq.

  analysis microarray rna-seq quantitative

• CCL8 as a promising prognostic factor in diffuse large B-cell lymphoma via M2 macrophage interactions: A bioinformatic analysis of the tumor microenvironment.

  PMID 36072582 · PMC9441746 · Frontiers in immunology · 2022 · 8 claims · 8 setups

  Has reproduction · 81

  Higher stromal and ESTIMATE scores are associated with favorable prognosis in DLBCL

  dlbcl ici-related degs ffpe estimate consensus differential

• A comparison of the large-scale gene expression patterns in summer and fall migratory Pantala flavescens (Fabricius) in northern China.

  PMID 39108562 · PMC11301579 · Ecology and evolution · 2024 · 8 claims · 4 setups

  Has reproduction · 93

  624 differentially expressed genes (DEGs) were identified between summer (M7) and fall (M10) migratory P. flavescens

  pantala bulk quantitative transcriptome

• Transcriptome profiling of radish (Raphanus sativus L.) root and identification of genes involved in response to Lead (Pb) stress with next generation sequencing.

  PMID 23840502 · PMC3688795 · PloS one · 2013 · 8 claims · 5 setups

  Has reproduction · 27

  A de novo radish root transcriptome of 68,940 assembled transcripts including 33,337 unigenes was generated, providing the first comprehensive molecular characterization of the radish root response to Pb stress.

  radish assembled rna-seq novo functional

• Uncovering the transcriptional landscape of estrogen-induced gonadal feminization in the Chinese giant salamander.

  PMID 41808025 · PMC13085422 · BMC genomics · 2026 · 8 claims · 7 setups

  Full-text index only

  E2 exposure induces male-to-female gonadal sex reversal in CGS, confirmed by histological evidence across developmental stages.

  gonadal tail-tip deg candidate rna-seq histology rt-qpcr

• Placental gene signatures associated with high neonatal adiposity: role for immune cell activation.

  PMID 41958865 · PMC13061145 · Journal of the Endocrine Society · 2026 · 8 claims · 8 setups

  Full-text index only

  A placental transcriptomic signature is associated with high neonatal adiposity

  placental term atlas neonates bulk gene protein-protein

• Heritable Genetic Effects Caused by a Single Generation of Captive Breeding.

  PMID 42015961 · PMC13093589 · Evolutionary applications · 2026 · 8 claims · 6 setups

  Full-text index only

  Hundreds of genes (385) are differentially expressed between offspring of first-generation hatchery (H×H) and natural-origin (N×N) steelhead reared in a common environment

  steelhead same rna-seq individual rna-seq differential snp

• Niacin promotes motor function recovery after spinal cord injury via Hcar2-dependent microglia immunometabolic regulation.

  PMID 42068080 · PMC13135113 · Clinical and translational medicine · 2026 · 8 claims · 8 setups

  Full-text index only

  Hcar2 is a microglia-enriched gene whose spinal cord expression is upregulated after SCI, peaking at 7 days post-injury

  spinal c57bl bv2 single-cell bulk sci