Experiments
Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).
-
Has reproduction · 71
Spatial organization shapes the turnover of a bacterial transcriptome.
PMID 27198188 · PMC4874777 · eLife · 2016 · 7 claims · 6 setups
The E. coli transcriptome is spatially organized genome-wide: mRNAs encoding inner-membrane proteins are enriched at the membrane, while mRNAs encoding cytoplasmic, periplasmic and outer-membrane proteins are distributed throughout the cytoplasm.
-
Full-text index only
Operon information improves gene expression estimation for cDNA microarrays.
PMID 16630355 · PMC1513396 · BMC genomics · 2006 · 7 claims · 3 setups
A hierarchical Bayesian model that borrows expression information from other genes within the same operon improves estimation of relative transcript levels.
-
Full-text index only
Threshold-dominated regulation hides genetic variation in gene expression networks.
PMID 18062810 · PMC2238762 · BMC systems biology · 2007 · 8 claims · 2 setups
Threshold robustness (insensitivity of a singular/regulating variable's equilibrium value to parameter perturbations, except threshold changes) increases with increasing response function steepness and is present even under Michaelis-Menten conditions, not just in the step-function limit.