Experiments
Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).
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Has reproduction
CRISPR/Cas9 Screens Reveal Multiple Layers of B cell CD40 Regulation.
PMID 31365872 · PMC6684324 · Cell reports · 2019 · 8 claims · 8 setups
Genome-wide CRISPR/Cas9 screening in Daudi B cells using CD40L-induced Fas upregulation as a readout identifies both positive and negative regulators of CD40
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Full-text index only
Systematic elucidation of genetic mechanisms underlying cholesterol uptake.
PMID 37228746 · PMC10203276 · Cell genomics · 2023 · 8 claims · 8 setups
Genome-scale CRISPR-Cas9 knockout screening in HepG2 cells identifies 490 genes whose disruption alters LDL-C uptake
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Has reproduction · 58
Histone hyperacetylation disrupts core gene regulatory architecture in rhabdomyosarcoma.
PMID 31784732 · PMC6886578 · Nature genetics · 2019 · 8 claims · 8 setups
SOX8 is a previously unrecognized core regulatory TF in FP-RMS, co-localizing with other CR TFs at SEs and essential for tumor cell growth
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Full-text index only
The ubiquitin ligase KLHL6 drives resistance to CD8(+) T cell dysfunction.
PMID 41535474 · PMC12979199 · Nature · 2026 · 8 claims · 8 setups
KLHL6 is a dual-negative regulator of both T cell exhaustion and mitochondrial dysfunction
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Has reproduction · 68
Identifying human pre-mRNA cleavage and polyadenylation factors by genome-wide CRISPR screens using a dual fluorescence readthrough reporter.
PMID 38587191 · PMC11077057 · Nucleic acids research · 2024 · 6 claims · 8 setups
A dual fluorescence (GFP-mCherry) readthrough reporter with a PAS inserted between the two reporters enables measurement of 3' end processing efficiency in living cells.