Experiments
Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).
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Has reproduction · 81
Macrophages on the run: Exercise balances macrophage polarization for improved health.
PMID 39476967 · PMC11585839 · Molecular metabolism · 2024 · 8 claims · 7 setups
Immediate/acute exercise triggers an M1 (pro-inflammatory) macrophage polarization surge.
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Has reproduction · 62
Metabolic profiling during malaria reveals the role of the aryl hydrocarbon receptor in regulating kidney injury.
PMID 33021470 · PMC7538157 · eLife · 2020 · 8 claims · 8 setups
Plasma AHR ligands derived from heme metabolism (biliverdin, bilirubin) and tryptophan/kynurenine pathway metabolites increase during acute Pc malaria in mice and acute cerebral malaria in humans
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Has reproduction · 98
The butyrophilin 1a1 knockout mouse revisited: Ablation of Btn1a1 leads to concurrent cell death and renewal in the mammary epithelium during lactation.
PMID 34938960 · PMC8664049 · FASEB bioAdvances · 2021 · 8 claims · 8 setups
BTN1A1 functions as an apical membrane receptor that forms a lipid-droplet secretion complex with the redox enzyme xanthine oxidoreductase (XDH)
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Has reproduction · 93
Disentangling the causal relationship between rabbit growth and cecal microbiota through structural equation models.
PMID 36536288 · PMC9762025 · Genetics, selection, evolution : GSE · 2022 · 8 claims · 4 setups
Structural equation models can decompose the total genetic effect on a production trait into a direct host genetic effect and an indirect effect exerted through the microbiota.
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Has reproduction · 76
Estimation of peptide elongation times from ribosome profiling spectra.
PMID 33885812 · PMC8136808 · Nucleic acids research · 2021 · 7 claims · 4 setups
A maximum likelihood statistical model using 915 context-defining parameters can neutralize technical biases (e.g. RNase cleavage preferences) in Ribo-Seq data and estimate peptide elongation times at single-codon resolution.
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Has reproduction · 73
Expression of neurofibromin 1 in colorectal cancer and cetuximab resistance.
PMID 34779495 · PMC8611403 · Oncology reports · 2022 · 7 claims · 8 setups
NF1 is highly expressed in cetuximab-sensitive colorectal cancer cell lines (NCI-H508, Caco2) but weakly expressed in cetuximab-resistant lines (KM12C, SW480)
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Has reproduction · 64
A Meta-Analysis of the Effects of Chronic Stress on the Prefrontal Transcriptome in Animal Models and Convergence With Existing Human Data.
PMID 41566898 · PMC12824456 · Brain and behavior · 2026 · 8 claims · 8 setups
A meta-analysis of 6 public PFC transcriptional profiling datasets (n=117 mice, 8 stress vs control contrasts) identified 133 genes consistently differentially expressed across chronic stress studies and paradigms (FDR<0.05)
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Has reproduction · 77
Electroacupuncture reshapes the microbial co-occurrence networks related to the behavioral and psychological symptoms of dementia in Alzheimer's disease.
PMID 41676443 · PMC12806058 · iMetaOmics · 2025 · 8 claims · 5 setups
Microbial keystone species and gut microbiota composition are highly variable during pathological development of BPSD in AD
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Has reproduction · 95
Energy, power, and infrastructure demands from electrifying airport ground support equipment at United States airports.
PMID 41912553 · PMC13199391 · Nature communications · 2026 · 8 claims · 4 setups
Electrifying major GSE at U.S. airports can significantly increase grid power and energy demand, with peak power at large airports reaching up to 20 MW and annual consumption approaching 51,000 MWh.
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Has reproduction · 89
What's Genetic Variation Got to Do with It? Starvation-Induced Self-Fertilization Enhances Survival in Paramecium.
PMID 32163147 · PMC7239694 · Genome biology and evolution · 2020 · 8 claims · 5 setups
Self-fertilization enhances heat shock resistance in P. tetraurelia in the absence of new genetic variation
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Has reproduction · 92
Large-scale integration of single-cell transcriptomic data captures transitional progenitor states in mouse skeletal muscle regeneration.
PMID 34773081 · PMC8589952 · Communications biology · 2021 · 8 claims · 7 setups
Large-scale integration of 111 sc/snRNAseq datasets captures rare, transitional myogenic progenitor states (commitment and fusion) that are poorly represented in individual datasets.
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Has reproduction · 59
Comparison between short-term stress and long-term adaptive responses reveal common paths to molecular adaptation.
PMID 35243257 · PMC8873613 · iScience · 2022 · 8 claims · 7 setups
Short-term stress and long-term adaptations share common metabolic pathways
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Has reproduction · 73
A transcriptomic atlas of Aedes aegypti reveals detailed functional organization of major body parts and gut regional specializations in sugar-fed and blood-fed adult females.
PMID 35471187 · PMC9113746 · eLife · 2022 · 8 claims · 5 setups
Created Aegypti-Atlas, an online RNAseq resource covering Ae. aegypti body parts, gut regions, and a blood meal digestion time course
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Has reproduction · 84
Main Factors Influencing the Gut Microbiota of Datong Yaks in Mixed Group.
PMID 35883324 · PMC9312300 · Animals : an open access journal from MDPI · 2022 · 7 claims · 6 setups
Gut microbial diversity (alpha and beta) differs significantly among domestic males, domestic females, and wild male Datong yaks.
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Has reproduction · 98
Systems spatiotemporal dynamics of traumatic brain injury at single-cell resolution reveals humanin as a therapeutic target.
PMID 35951114 · PMC9372016 · Cellular and molecular life sciences : CMLS · 2022 · 8 claims · 8 setups
Coordinated gene expression patterns across cell types are disrupted and re-organized by mTBI with distinct regional, cellular, and temporal (24-h vs 7-day) specificity.
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Has reproduction · 42
KAGE: fast alignment-free graph-based genotyping of SNPs and short indels.
PMID 36195962 · PMC9531401 · Genome biology · 2022 · 7 claims · 7 setups
KAGE combines population-based kmer count modeling with single-variant prior adjustment into an alignment-free genotyper that matches the accuracy of the best existing alignment-free genotypers while being an order of magnitude faster.
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Has reproduction · 85
Distinct sympathetic projections to brown fat regulate thermogenesis and glucose tolerance.
PMID 41559445 · PMC12945688 · Nature metabolism · 2026 · 8 claims · 8 setups
Distinct sympathetic neuron subpopulations in the stellate ganglion (SG) innervating iBAT parenchyma versus its vasculature mediate separable functions of the depot.
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Has reproduction · 59
Single-cell transcriptomics reveals maturation of transplanted stem cell-derived retinal pigment epithelial cells toward native state.
PMID 37339216 · PMC10293804 · Proceedings of the National Academy of Sciences of the United States of America · 2023 · 8 claims · 8 setups
Subretinally transplanted stem cell-derived RPE (ESC- and iPSC-derived) retain RPE identity and survive in vivo for at least 30 days in immunocompetent rabbit eyes
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Has reproduction · 81
Enabling Single-Cell Drug Response Annotations from Bulk RNA-Seq Using SCAD.
PMID 36762572 · PMC10104628 · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023 · 7 claims · 7 setups
SCAD, a transfer learning framework integrating adversarial discriminative domain adaptation (ADDA), can infer single-cell drug sensitivities by transferring knowledge from bulk RNA-seq pharmacogenomic data (GDSC) to scRNA-seq target domains
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Has reproduction · 77
Sequential structure probing of cotranscriptional RNA folding intermediates.
PMID 40450030 · PMC12126503 · Nature communications · 2025 · 8 claims · 6 setups
TECprobe-LM (linked-multipoint Transcription Elongation Complex RNA structure probing) directly measures cotranscriptional rearrangement of RNA structures by sequentially arresting RNAP at two or more template positions and chemically probing nascent RNA at each point