Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• The impact of peptide abundance and dynamic range on stable-isotope-based quantitative proteomic analyses.

  PMID 18798661 · PMC2746028 · Journal of proteome research · 2008 · 8 claims · 7 setups

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  Over half of confidently identified peptides in complex mixtures have S/N ratios below 10 on both FT-ICR and Orbitrap instruments

  jurkat silac-based sds-page database

• Stable isotope labeling tandem mass spectrometry (SILT): integration with peptide identification and extension to data-dependent scans.

  PMID 18774841 · PMC2707264 · Journal of proteome research · 2008 · 8 claims · 5 setups

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  Using MS/MS ion intensities with stable isotope labeling (SILT) decreases the effects of contamination from unrelated co-eluting compounds compared to precursor ion intensity methods.

  astrocytes hepg2 app695δnl labeled nano-lc sds-page immunoprecipitation

• Integrated algorithms for high-throughput examination of covalently labeled biomolecules by structural mass spectrometry.

  PMID 19788317 · PMC2764328 · Analytical chemistry · 2009 · 7 claims · 4 setups

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  ProtMapMS automates data format conversion, mass spectrum interpretation, peptide detection/verification, modification site confirmation, and quantification of peptide oxidation extent from covalent labeling MS data

  insulin oxidative enzymatic computational

• High quality catalog of proteotypic peptides from human heart.

  PMID 18803417 · PMC2765113 · Journal of proteome research · 2008 · 8 claims · 4 setups

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  A catalog of 4476 proteotypic peptides representing 2558 human heart proteins was generated from MudPIT analyses of nonfailing and failing left-ventricular explants

  left-ventricular unfractionated heart mudpit selected preparation

• Contributions of proteomics to understanding phagosome maturation.

  PMID 18331591 · PMC2613258 · Cellular microbiology · 2008 · 8 claims · 8 setups

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  Proteomic studies across many species have identified hundreds of proteins associated with phagosomes, revealing conserved functional classes (vATPase subunits, GTPases, hydrolases, SNAREs, Rabs, cytoskeletal proteins).

  macrophage dictyostelium drosophila entamoeba quantitative 2dge prefractionation

• Proteomic and phospho-proteomic profile of human platelets in basal, resting state: insights into integrin signaling.

  PMID 19859549 · PMC2762604 · PloS one · 2009 · 8 claims · 8 setups

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  A comprehensive platelet proteome of 1507 unique proteins was identified from ten independent human platelet samples, the most comprehensive platelet proteome assembled to date

  platelets platelet anti-coagulated lc-ms phospho-proteomic membrane

• Proteomic analysis of protein deposits on worn daily wear silicone hydrogel contact lenses.

  PMID 18989384 · PMC2579937 · Molecular vision · 2008 · 8 claims · 4 setups

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  Worn silicone hydrogel contact lenses deposit a wide array of proteins from the tear film and other sources.

  deposit excised pooled worn sds-page in-gel lc-ms-ms

• Toxicoproteomics: a parallel approach to identifying biomarkers.

  PMID 12940285 · PMC1241639 · Environmental health perspectives · 2003 · 8 claims · 8 setups

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  Combining parallel DNA microarray and proteomic analyses on the same tissues merges microarray's gene discovery power with proteomics' ability to exploit post-translational modifications for biomarker identification.

  liver serum peptide digested two-dimensional seldi maldi