Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 42

System / cell line: cell-type ✕ Assay: proliferation ✕ Clear

MAZ-mediated tumor progression and immune evasion in hormone receptor-positive breast cancer: Targeting tumor microenvironment and PCLAF+ subtype-specific therapy.

PMID 39805182 · PMC11780959 · Translational oncology · 2025 · 6 claims · 8 setups

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A C3 PCLAF+ tumor cell subtype identified by scRNA-seq shows high proliferation/differentiation potential and is linked to aggressive tumor behavior and poor prognosis in HR+BC

hr+bc mda-mb-361 tcga scrna-seq cellchat pyscenic
comBO: A combined human bone and lympho-myeloid bone marrow organoid for preclinical modeling of hematopoietic disorders.

PMID 41734765 · PMC7618947 · Cell stem cell · 2026 · 8 claims · 8 setups

Has reproduction · 65

comBO is a single iPSC-derived organoid differentiation that generates osteolineage, vascular, lymphoid, and myeloid compartments together

hipsc-derived combo combo-derived healthy-donor flow single-cell confocal
A P4HA2 hypoxia signature derived from single cell atlas stratifies conserved subtypes with prognostic significance in cervical squamous cell carcinoma.

PMID 41559646 · PMC12910786 · BMC cancer · 2026 · 6 claims · 8 setups

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A tumor cell metaprogram (MP7) identified from scRNA-seq of CSCC shows elevated hypoxia, invasion, metastasis, proliferation, and angiogenesis scores compared to other metaprograms.

cscc tcga-cscc mp7 siha single-cell bulk gene
A pan-cancer single-cell transcriptomic atlas of human bone metastases.

PMID 41619722 · PMC12923970 · Cell reports. Medicine · 2026 · 8 claims · 8 setups

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Constructed a pan-cancer single-cell transcriptomic atlas of 62 human bone metastases (predominantly spinal) across 13 primary cancer types, with paired primary tumor and normal bone marrow samples.

bone paired plasmacytoma malignant scrna-seq ihc infercnv
FOXA1 mutations co-opt nascent transcription factor networks in partnership with androgen receptor to enhance prostate tumorigenicity.

PMID 41621066 · PMC13050545 · Cell reports · 2026 · 8 claims · 8 setups

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FOXA1 mutations in a 874-tumor cohort cluster into missense, in-frame indel, and truncation subgroups, with indels concentrated at residues M253/E255

prostate targeted single-nucleus scatac-seq
Integrative single-cell analysis uncovers distinct tumour microenvironment ecotypes and immune evasion across skin cancers.

PMID 41636115 · PMC12869349 · Clinical and translational medicine · 2026 · 7 claims · 8 setups

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A malignant NARS2+NDUFC2+ melanoma cell subpopulation with reduced MHC-I expression is enriched in advanced-stage tumours and associated with worse survival and immunotherapy response.

skin prognosis melanoma macrophage single-cell bulk immunofluorescence
Targeted and personalized immunotherapy in lung adenocarcinoma: single-cell RNA sequencing of MAFF+ tumor cells and the therapeutic potential of FOS.

PMID 40936936 · PMC12420628 · Frontiers in immunology · 2025 · 7 claims · 8 setups

Has reproduction · 71

A highly stem-like C0 MAFF+ tumor cell subtype dominates invasive LUAD, producing chemokines and activating lipid metabolism

luad tumor a549 single-cell infercnv pseudotime
Unveiling the NEFH+ malignant cell subtype: Insights from single-cell RNA sequencing in prostate cancer progression and tumor microenvironment interactions.

PMID 39759507 · PMC11695424 · Frontiers in immunology · 2024 · 8 claims · 8 setups

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A malignant cell subtype in PCa with high expression of NEFH was identified, located at the differentiation terminal, showing higher malignancy and association with advanced tumor lesions.

pca malignant tcga mda single-cell infercnv pseudotime
Androgen activity in the male embryonic hindbrain drives lethal PFA ependymoma.

PMID 41882358 · PMC13083265 · Nature · 2026 · 8 claims · 8 setups

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The cellular hierarchy of PFA ependymoma is less differentiated in male than in female patients

pfa pfa-epn normal hindbrain single-cell kaplan-meier literature
Chemotherapy-induced reactive myelopoiesis promotes expansion of immunosuppressive neutrophil-like monocytes in mice and humans.

PMID 41945895 · PMC13232731 · JCI insight · 2026 · 8 claims · 8 setups

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Monocytes from lymphoma patients receiving CTX-containing chemotherapy show variable, often chemotherapy-induced or -enhanced, immunosuppressive activity against T cells

pbmcs bone sorted facs-sorted scrna-seq flow atac-seq
Dissecting tumor heterogeneity in colorectal cancer: uncovering the role of BCL2L1(+) cells through single-cell analysis.

PMID 41958675 · PMC13056825 · Frontiers in immunology · 2026 · 8 claims · 8 setups

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scRNA-seq identifies five CRC tumor cell subtypes, with the C4 BCL2L1+ subtype predominantly enriched in liver metastases and showing enhanced proliferation, metabolic reprogramming, and anti-apoptotic activity

crc epcs malignant tcga scrna-seq infercnv cytotrace
SPP1(+) macrophage-driven interactions shape the tumor microenvironment in lymph node metastatic acral melanoma.

PMID 42020397 · PMC13230793 · Cell death & disease · 2026 · 8 claims · 8 setups

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LN+ acral melanoma shows preferential SPP1+ signaling, including autocrine amplification within SPP1+ macrophages and paracrine interaction with S100A8+ melanoma cells via the SPP1-CD44 axis

tumor microarray thp-1 a375 scrna-seq immunofluorescence western
Multi-Omics reveals SPP1 + malignant and CXCR4(+) TAM crosstalk predicts immunotherapy response in lung adenocarcinoma.

PMID 42045760 · PMC13187092 · Discover oncology · 2026 · 8 claims · 8 setups

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SPP1+ malignant and CXCR4+ TAM crosstalk drives CD8 T cell exhaustion and induces poor immunotherapy response

luad tcga-luad epithelial a549 single-cell spatial bulk
Integrating single-cell and bulk transcriptomes to reveal prognostic and immunological features of ecDNA-related genes in osteosarcoma.

PMID 42047819 · PMC13125642 · Cancer immunology, immunotherapy : CII · 2026 · 7 claims · 8 setups

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A novel ecDNA-related Gene Prognostic Score Model (EGPSM) was constructed using an integrated framework of 101 machine learning algorithm combinations and validated in training, testing, and external cohorts.

osteosarcoma treatment-naive bulk 143b bulk single-cell cibersort
Identification of Cell Subpopulation-Specific Driver Genes Reveals Ideal Candidates for Renal Cell Carcinoma Immunotherapy.

PMID 42074110 · PMC13115843 · International journal of molecular sciences · 2026 · 8 claims · 8 setups

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25 immune-related candidate driver genes were identified from tumor, myeloid, and lymphoid cell gene regulatory networks (GRNs) using SCENIC and topological Q statistics.

kidney lymphoid rcc tcga-kirc single-cell scenic genome-wide
Paneth cell SIRT1 deficiency increases intestinal stress resistance by modulating the gut microbiota.

PMID 41826553 · PMC13076647 · EMBO reports · 2026 · 8 claims · 8 setups

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Generated a novel Paneth-cell-specific SIRT1 knockout mouse model (SIRT1 PKO, Sirt1 f/f;Defa6-Cre+)

small immune facs-sorted ileum single-cell facs qpcr
MECP2 mutations rewire human ESC fate and bias cortical lineage commitment.

PMID 42030940 · PMC13163216 · Stem cell reports · 2026 · 8 claims · 8 setups

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MECP2 mutations induce an early naïve-like transcriptional drift in human ESCs, marked by upregulation of ZFP42/REX1 and other naïve-enriched markers

isogenic undifferentiated 3-month bulk bulk single-cell single-nucleus
PW1(+) cells give rise to cardiac adipocytes during development and myofibroblasts following injury.

PMID 42035143 · PMC13255232 · Stem cell research & therapy · 2026 · 8 claims · 8 setups

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PW1+ cardiac mesenchymal cells serve as a progenitor population that gives rise to cardiac adipocytes during postnatal heart development

heart pw1 sorted non-cardiomyocyte quantitative genetic adipogenesis
Single-cell and spatial transcriptome analysis reveals the potential therapeutic targets for testicular sex cord-stromal cell tumor.

PMID 42057139 · PMC13130799 · Biomarker research · 2026 · 8 claims · 8 setups

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Tumor areas of TSCST show significantly low expression of immune cell genes, indicating an immune-cold tumor microenvironment

fresh fetal paraffin-embedded paraffin single-nucleus scrna-seq spatial
Multi-Omic Profiling of T Cell-Mediated Rejection After Kidney Transplantation Reveals B Cell Receptor Repertoire Expansion and Its Prognostic Relevance.

PMID 41467897 · PMC12752722 · FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026 · 8 claims · 8 setups

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The BCR repertoire, particularly the IgG isotype, is significantly expanded in TCMR compared to stable renal function (STA) across independent renal transplant cohorts

kidney healthy lp-1 bcr bulk triple

Experiments

MAZ-mediated tumor progression and immune evasion in hormone receptor-positive breast cancer: Targeting tumor microenvironment and PCLAF+ subtype-specific therapy.

comBO: A combined human bone and lympho-myeloid bone marrow organoid for preclinical modeling of hematopoietic disorders.

A P4HA2 hypoxia signature derived from single cell atlas stratifies conserved subtypes with prognostic significance in cervical squamous cell carcinoma.

A pan-cancer single-cell transcriptomic atlas of human bone metastases.

FOXA1 mutations co-opt nascent transcription factor networks in partnership with androgen receptor to enhance prostate tumorigenicity.

Integrative single-cell analysis uncovers distinct tumour microenvironment ecotypes and immune evasion across skin cancers.

Targeted and personalized immunotherapy in lung adenocarcinoma: single-cell RNA sequencing of MAFF+ tumor cells and the therapeutic potential of FOS.

Unveiling the NEFH+ malignant cell subtype: Insights from single-cell RNA sequencing in prostate cancer progression and tumor microenvironment interactions.

Androgen activity in the male embryonic hindbrain drives lethal PFA ependymoma.

Chemotherapy-induced reactive myelopoiesis promotes expansion of immunosuppressive neutrophil-like monocytes in mice and humans.

Dissecting tumor heterogeneity in colorectal cancer: uncovering the role of BCL2L1(+) cells through single-cell analysis.

SPP1(+) macrophage-driven interactions shape the tumor microenvironment in lymph node metastatic acral melanoma.

Multi-Omics reveals SPP1 + malignant and CXCR4(+) TAM crosstalk predicts immunotherapy response in lung adenocarcinoma.

Integrating single-cell and bulk transcriptomes to reveal prognostic and immunological features of ecDNA-related genes in osteosarcoma.

Identification of Cell Subpopulation-Specific Driver Genes Reveals Ideal Candidates for Renal Cell Carcinoma Immunotherapy.

Paneth cell SIRT1 deficiency increases intestinal stress resistance by modulating the gut microbiota.

MECP2 mutations rewire human ESC fate and bias cortical lineage commitment.

PW1(+) cells give rise to cardiac adipocytes during development and myofibroblasts following injury.

Single-cell and spatial transcriptome analysis reveals the potential therapeutic targets for testicular sex cord-stromal cell tumor.

Multi-Omic Profiling of T Cell-Mediated Rejection After Kidney Transplantation Reveals B Cell Receptor Repertoire Expansion and Its Prognostic Relevance.