Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Activation instead of blocking mesolimbic dopaminergic reward circuitry is a preferred modality in the long term treatment of reward deficiency syndrome (RDS): a commentary.

  PMID 19014506 · PMC2615745 · Theoretical biology & medical modelling · 2008 · 8 claims · 6 setups

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  A biphasic treatment approach—acute DA receptor blocking followed by long-term DA release/activation at the NAc—is needed to treat RDS without inducing abnormal mood or craving.

  kidney alcohol-preferring obese rodents receptor dna-directed meta-analysis

• ChemR23 prevents phenotypic switching of vascular smooth muscle cells into macrophage-like foam cells in atherosclerosis.

  PMID 41264461 · PMC13017563 · Cardiovascular research · 2026 · 8 claims · 7 setups

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  Non-haematopoietic (vascular) ChemR23 deficiency increases atherosclerotic lesion size and enhances VSMC proliferation and VSMC-derived foam cell formation

  apoe adventitia-stripped advanced aortic atherosclerotic bulk single-cell

• Heritable ER stress impairs mitochondrial metabolism and maintenance of hematopoietic stem cells after low-dose irradiation.

  PMID 41675062 · PMC12886522 · iScience · 2026 · 8 claims · 8 setups

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  Proliferating 20 mGy-irradiated HSC exhibit oxidative stress and altered metabolism with increased mitochondrial ROS and mitochondrial Ca2+ overload compared to non-irradiated HSC

  cd45.1 hsc hspc-enriched bone flow carbonylation

• A Plastic EMP1+ to LGR5+ Cell State Conversion as a Bypass to KRASG12D Pharmacologic Inhibition in Metastatic Colorectal Cancer.

  PMID 41128661 · PMC12877754 · Cancer discovery · 2026 · 8 claims · 8 setups

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  RMC-9945 exerts durable antitumor activity in early-stage liver metastasis but has diminished therapeutic effect in advanced metastatic disease

  aktp colorectal drug single-cell rnascope

• Sensitizer-Induced Basophils Accelerate Skin Re-Epithelialization via IL-4/IL-13-Mediated Macrophage Polarization.

  PMID 41787818 · PMC13139821 · Allergy · 2026 · 8 claims · 8 setups

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  Basophils accumulate in wounded and oxazolone (OXA)-sensitized skin, peaking around day 3–6 post-injury

  skin ear dorsal mcpt8-ct single-cell flow rt-qpcr

• Enforced MYC expression directs a distinct transcriptional state during plasma cell differentiation.

  PMID 40721291 · PMC12305944 · Life science alliance · 2025 · 8 claims · 7 setups

  Has reproduction · 74

  Acute MYC (T58I) and BCL2 overexpression drives an aberrant B-cell differentiation phenotype with altered surface marker expression while functional antibody secretion is retained

  peripheral rna-seq flow edu antibody

• ZFHX4 is necessary for dopaminergic neuron differentiation and controls cell cycle by regulating LIN28A.

  PMID 42208531 · PMC13261933 · Stem cell reports · 2026 · 8 claims · 8 setups

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  ZFHX4 is a super-enhancer-controlled transcription factor induced during mDAN specification

  ipsc-derived smnpcs postmortem cut&tag bulk shrna

• Integrative Multiomic Classification Reveals Distinct Origins and Evolutionary Trajectories of Thymic Epithelial Tumors.

  PMID 41671387 · PMC13012242 · Cancer research · 2026 · 8 claims · 8 setups

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  TETs stratify into three molecular subgroups with distinct origins: GTF2I-type thymomas, CN-type thymomas, and thymic carcinomas

  tet thymic hek293t whole-exome whole-genome bulk

• l-2-Hydroxyglutarate impairs neuronal differentiation through epigenetic activation of MYC expression.

  PMID 41842973 · PMC13132370 · The Journal of clinical investigation · 2026 · 8 claims · 8 setups

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  L2HGDH deficiency causes L-2HG (not D-2HG) accumulation in patient plasma, fibroblasts, iPSCs, and NPCs

  plasma patient-derived unedited day-14 metabolomics crispr proliferation

• Disruption of the EGFR E884-R958 ion pair conserved in the human kinome differentially alters signaling and inhibitor sensitivity.

  PMID 19015641 · PMC2633425 · Oncogene · 2009 · 8 claims · 8 setups

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  E884K works in concert with L858R in-cis, in a dominant fashion, to differentially alter EGFR downstream signaling and inhibitor sensitivity in an inhibitor-specific manner

  cos-7 kinase japanese western cellular mts

• Human CRAMP1 specifically promotes the expression of histone H1 genes.

  PMID 41663757 · PMC12979687 · EMBO reports · 2026 · 8 claims · 8 setups

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  CRAMP1 is a selective regulator of histone H1 gene expression that does not significantly affect core histone gene expression

  cancer hek293t rpe1 genome-wide immunoprecipitation-mass western

• Metabolic Adaptation of CD8⁺ T Cells Limits the Efficacy of Fatty Acid Oxidation Inhibition in Type 1 Diabetes.

  PMID 41800251 · PMC12965062 · International journal of biological sciences · 2026 · 8 claims · 8 setups

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  TMZ enhances mitochondrial membrane potential and suppresses fatty acid oxidation (FAO) in human T cells

  peripheral endoc-βh5 nod pancreatic mitochondrial extracellular glucose-stimulated

• Exploring the mechanism of action of abemaciclib in breast cancer through circulating chromatin fragments.

  PMID 41845059 · PMC13149665 · Communications medicine · 2026 · 8 claims · 5 setups

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  cfDNA concentrations are significantly higher in breast cancer patients than healthy donors and decline following abemaciclib therapy

  serum t47d edger-normalized cfdna proliferation pathway

• Chemotherapy-induced reactive myelopoiesis promotes expansion of immunosuppressive neutrophil-like monocytes in mice and humans.

  PMID 41945895 · PMC13232731 · JCI insight · 2026 · 8 claims · 8 setups

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  Monocytes from lymphoma patients receiving CTX-containing chemotherapy show variable, often chemotherapy-induced or -enhanced, immunosuppressive activity against T cells

  pbmcs bone sorted facs-sorted scrna-seq flow atac-seq

• Tumor methionine metabolism drives T-cell exhaustion in hepatocellular carcinoma.

  PMID 33674593 · PMC7935900 · Nature communications · 2021 · 8 claims · 8 setups

  Has reproduction · 78

  A transcriptome-derived T-cell exhaustion score (ES) is prognostic for HCC patient survival independent of known clinical/molecular factors

  hcc-associated hcc malignant cd8+ single-cell bulk metabolomics

• Utilization of genomic signatures to identify phenotype-specific drugs.

  PMID 19714244 · PMC2729377 · PloS one · 2009 · 8 claims · 8 setups

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  A RAS pathway gene expression signature applied to NCI-60 cells identifies compounds selectively active against RAS-activated cells, including the MEK inhibitor Hypothemycin

  nci-60 breast mda-mb-231 signature-drug gene signature

• Anti-CSF-1R therapy with combined immuno-chemotherapy coordinate an adaptive immune response to eliminate macrophage enriched triple negative breast cancers.

  PMID 41484081 · PMC12858953 · Nature communications · 2026 · 8 claims · 8 setups

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  Combined low-dose CTX + anti-CSF-1R (SNDX-ms6352) is highly effective against aggressive metastatic Trp53-null TNBC models with high macrophage infiltration, producing complete tumor regression in claudin-low models.

  trp53-null complete t12 cell-deficient imaging survival tumor

• chromIDEAS reveals epigenetic dynamics via multi-dimensional clustering of chromatin states.

  PMID 41816913 · PMC12980073 · Nucleic acids research · 2026 · 8 claims · 8 setups

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  chromIDEAS groups chromatin states into functionally coherent clusters by jointly analyzing epigenetic composition and genomic distribution

  thp1 cd34+ chromideas chip-seq atac-seq

• Stage-specific epigenetic priming amplifies gene activation during lineage commitment.

  PMID 41894493 · PMC13025117 · Science advances · 2026 · 8 claims · 8 setups

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  Full-body Msl1 knockout causes embryonic lethality by E10.5, with morphological/developmental delay detectable already at E8.5

  embryos e9.5 mesc-derived bright-field western 10x

• The oncogene AAMDC links PI3K-AKT-mTOR signaling with metabolic reprograming in estrogen receptor-positive breast cancer.

  PMID 33772001 · PMC7998036 · Nature communications · 2021 · 8 claims · 8 setups

  Has reproduction · 85

  AAMDC is an amplified/overexpressed oncogene in a subgroup of ER-positive breast cancers (IntClust2) associated with poor prognosis

  breast luminal sum52pe t-47d immunohistochemistry fluorescence qrt-pcr