Experiments
Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).
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Assessment of serum proteomics to detect large colon adenomas.
PMID 18708413 · PMC2561171 · Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2008 · 7 claims · 1 setups
In the primary, pre-specified blinded validation analysis, the serum proteomics (ProteomeQuest) model showed no significant discrimination between large adenoma and normal subjects (accuracy 51%).
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The process chain for peptidomic biomarker discovery.
PMID 16410650 · PMC3850862 · Disease markers · 2006 · 8 claims · 3 setups
Peptidomics (comprehensive analysis of peptides and small proteins <20 kDa) fills a methodological gap left by standard proteomics, which mainly addresses proteins in the ~10-200 kDa range.
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Proteomics as a method for early detection of cancer: a review of proteomics, exhaled breath condensate, and lung cancer screening.
PMID 18095050 · PMC2150625 · Journal of general internal medicine · 2008 · 8 claims · 7 setups
Protein expression is closely aligned with cellular activity, unlike genomic changes which may have no functional significance
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Sample preparation for serum/plasma profiling and biomarker identification by mass spectrometry.
PMID 17166507 · PMC7094463 · Journal of chromatography. A · 2007 · 8 claims · 8 setups
Standardizing sample preparation procedures for serum/plasma profiling is critical for obtaining reliable biomarkers, since slight procedural changes can produce very different protein profiles.
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The promise of biomarkers in colorectal cancer detection.
PMID 15322316 · PMC3839323 · Disease markers · 2004 · 8 claims · 8 setups
A panel/combination of biomarkers is likely to provide better predictive value for early CRC detection than any single biomarker.