Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Multimodal techniques for diagnosis and prognosis of Alzheimer's disease.

  PMID 19829371 · PMC2810658 · Nature · 2009 · 8 claims · 8 setups

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  AD pathology accumulates for approximately 10-15 years in a preclinical phase before synaptic and neuronal loss manifest as cognitive decline

  subjects csf peripheral amyloid structural functional

• Applying proteomics to the diagnosis and treatment of ALS and related diseases.

  PMID 19670321 · PMC2836583 · Muscle & nerve · 2009 · 8 claims · 8 setups

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  Protein-based biomarkers for ALS/MND require further verification and large-scale validation/qualification studies, including disease mimics, before clinical use

  csf spinal biofluid muscle 2d-dige antibody luminex

• Shotgun proteomic analysis of cerebrospinal fluid using off-gel electrophoresis as the first-dimension separation.

  PMID 18778093 · PMC4582942 · Journal of proteome research · 2008 · 6 claims · 4 setups

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  OGE first-dimension fractionation enabled identification of 156 unique CSF proteins compared to 115 identified using SCX fractionation on the same CSF pool

  pooled csf spectra shotgun trypsin peptide

• CSF metabolic and proteomic profiles in patients prodromal for psychosis.

  PMID 17712404 · PMC1942084 · PloS one · 2007 · 8 claims · 5 setups

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  CSF metabolic and proteomic profiles of IPS patients are distributed across, and partially overlap with, the profiles of first-onset drug-naïve schizophrenia patients and healthy controls

  csf subjects 1h-nmr seldi partial

• Glia maturation factor gamma (GMFG): a cytokine-responsive protein during hematopoietic lineage development and its functional genomics analysis.

  PMID 17127212 · PMC5054077 · Genomics, proteomics & bioinformatics · 2006 · 8 claims · 6 setups

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  GMFG is a cytokine-responsive protein in EPO-induced (erythroid) and G-CSF-induced (myeloid) hematopoietic lineage development

  ac133+ excised e14 tissues 2-de lc-ms rt-pcr

• Biomarker discovery in neurodegenerative diseases: a proteomic approach.

  PMID 18938247 · PMC2939006 · Neurobiology of disease · 2009 · 6 claims · 8 setups

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  Proteomic profiling of CSF and plasma can identify candidate protein biomarkers that distinguish AD patients from controls with high sensitivity and specificity

  csf plasma brain 2-dge lc-ms seldi-tof-ms

• Identification of disease markers in human cerebrospinal fluid using lipidomic and proteomic methods.

  PMID 16410651 · PMC3851111 · Disease markers · 2006 · 8 claims · 3 setups

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  Lipids comprise the bulk of the dry mass of the brain and serve structural, insulating, energy-storage, and signaling/inflammatory-mediator roles.

  brain cerebrospinal electrospray liquid selected

• Prioritized mass spectrometry increases the depth, sensitivity and data completeness of single-cell proteomics.

  PMID 37012480 · PMC10172113 · Nature methods · 2023 · 8 claims · 5 setups

  Has reproduction · 90

  pSCoPE (prioritized precursor selection via MaxQuant.Live) increases sensitivity, data completeness, and proteome coverage more than twofold over shotgun single-cell proteomics

  bulk hek293 single-cell bone prioritized single-cell spike-in