Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Pleiotropic effects of MORC2 derive from its epigenetic signature.

  PMID 40302207 · PMC12782172 · Brain : a journal of neurology · 2026 · 8 claims · 8 setups

  Has reproduction

  A MORC2-specific DNA methylation episignature exists that is universal across all MORC2-associated phenotypes and conserved across blood and fibroblast tissue

  blood fibroblasts fibroblast patient-derived methylation svm phenotype-specific

• Multiomics assessment of lung adenocarcinoma subtypes defined through tumor purity-adjusted DNA methylation.

  PMID 41691315 · PMC12927254 · Genome medicine · 2026 · 8 claims · 8 setups

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  Tumor purity-adjusted DNA methylation profiling of 95 primary LUAD samples identifies four distinct epigenetic subtypes (epitypes M1-M4)

  luad methylation sequencing targeted

• TiSMeD: A tissue-specific methylation and expression database for biomarker and translational applications.

  PMID 41883585 · PMC13011251 · Molecular therapy. Nucleic acids · 2026 · 8 claims · 8 setups

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  TiSMeD integrates 6,782 methylomes, 16,894 transcriptomes, and 241 proteomes across 48 normal human tissues into a searchable database

  normal plasma case-control tcga methylation transcriptome proteomics

• Mass spectrometry for proteomics.

  PMID 18718552 · PMC2642903 · Current opinion in chemical biology · 2008 · 8 claims · 8 setups

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  New instrumentation (Orbitrap) and new fragmentation methods (ETD) have enabled exciting new areas of proteomic application

  digested intact yeast large shotgun top-down quantitative

• A 15-layer multi-omics analysis of gastric cancer ecotypes provides therapeutic insights.

  PMID 42013851 · PMC13198309 · Cell reports. Medicine · 2026 · 8 claims · 8 setups

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  A 15-layer multi-omics atlas of 159 primary gastric adenocarcinomas and 30 matched normal adjacent tissues was generated, including previously unprofiled layers such as glycoproteomics, XL-MS-based PPI mapping, metabolomics, and tumor microbiome data

  gastric whole-exome methylation sequencing

• The field of tissue injury in the lung and airway.

  PMID 19138985 · PMC2705781 · Cancer prevention research (Philadelphia, Pa.) · 2008 · 8 claims · 8 setups

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  Field cancerization and the field of injury reflect molecular changes (genomic, epigenomic, transcriptomic, proteomic) present in histologically normal-appearing tissue distant from and independent of a tumor, throughout the carcinogen-exposed respiratory epithelium

  bronchial saliva resected paraffin-embedded whole-genome mtdna methylation-specific

• Epigenomic, transcriptomic, and proteomic characterization of breast cancer cell line reference samples.

  PMID 41539304 · PMC12853167 · Cell reports methods · 2026 · 8 claims · 5 setups

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  Comprehensive multi-omics reference materials (ATAC-seq, Methyl-seq, RNA-seq, MS-proteomics) were generated for paired HCC1395/HCC1395BL cell lines as a community benchmarking resource

  hcc1395 atac-seq methyl-seq bulk

• Multi-omic identification of key transcriptional regulatory programs during endurance exercise training in rats.

  PMID 41862462 · PMC13168590 · Nature communications · 2026 · 8 claims · 7 setups

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  Gene regulatory responses to endurance exercise training (EET) are predominantly tissue-specific rather than shared across tissues

  tissues same skm-gn rna-seq atac-seq rrbs

• Application of OMICS technologies in occupational and environmental health research; current status and projections.

  PMID 19933307 · PMC2910417 · Occupational and environmental medicine · 2010 · 8 claims · 6 setups

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  Five OMICS technologies are well established: genotyping, transcriptomics, epigenomics, proteomics, and metabolomics

  population genomic blood genome array-based comparative gene

• RMzyme: regulations of RNA-modifying enzymes in humans.

  PMID 41672979 · PMC12895048 · Signal transduction and targeted therapy · 2026 · 8 claims · 7 setups

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  RMzyme is a comprehensive multiomics knowledgebase covering 179 human RNA-modifying proteins across 18 major RNA modification types and 63 human tissues

  nomo1 molm13 tissues cptac merip-seq bulk single-cell

• Developmental reprogramming underlies chemotherapy resistance in favorable-histology Wilms tumor.

  PMID 41850280 · PMC13103949 · Cell reports · 2026 · 8 claims · 8 setups

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  Chemotherapy-resistant KT-47R tumors show blastemal predominance and reduced stromal content compared to pre-treatment KT-47PT

  kt-47 kt-47pt histology whole-exome cut&tag

• GLYATL1 is associated with metabolic and epigenetic changes and with endocrine resistance in luminal breast cancer.

  PMID 42050691 · PMC13126711 · Clinical epigenetics · 2026 · 8 claims · 8 setups

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  GLYATL1 expression is upregulated in AI-resistant breast cancer cell models and in patients undergoing AI therapy

  mcf7 lysates rna-sequencing atac-sequencing epic

• Ectopic CD11c Drives SMAD3-Mediated Aberrant Antigen Presentation and Epithelial-Mesenchymal Transition in Esophageal Squamous Cell Carcinoma.

  PMID 41799568 · PMC12963642 · Cancer communications (London, England) · 2026 · 8 claims · 13 setups

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  An ESCC epithelial cell subcluster with ectopic CD11c (ITGAX) expression, found in both mice and humans, exhibits concurrent impaired antigen presentation and EMT phenotypes

  4-nqo-induced escc esophageal lung multiplex flow whole-genome