Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 353

Assay: qpcr ✕ Clear

Cardiac conduction system malformations in heterotaxy result from dysregulated Pitx2 expression.

PMID 41734036 · PMC13043103 · JCI insight · 2026 · 8 claims · 8 setups

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Cryptic-/- embryos (right isomerism model) develop bilateral sinoatrial nodes and an ectopic anterior AV node and bundle, accompanied by reduced Pitx2 expression

cryptic embryo pitx2 lefty1 situ immunostaining cardiac
ASCL1 promotes nuclear shrinkage in transdifferentiation by suppressing NUP37.

PMID 41759523 · PMC12985393 · Stem cell reports · 2026 · 7 claims · 8 setups

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ASCL1-mediated transdifferentiation (AMp) of human fibroblasts to induced neurons causes marked nuclear shrinkage while cell size remains unchanged

mrc5 ag22056 ipsc-derived embryonic immunofluorescence single-cell rt-qpcr
Targeting the Lipid Metabolism Proteins FASN and GPAM in Alveolar Type II Cells Decreases Lung Metastasis.

PMID 41778850 · PMC7619144 · Cancer discovery · 2026 · 7 claims · 8 setups

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AT2 cells and surfactant lipids (e.g., PC, PE, PI, PG) are enriched in the vicinity of breast cancer lung metastases in both patients and mice

postmortem lungs lung at2 immunohistochemistry maldi-msi longitudinal
Differential fates of Kazald gene quartet: Ancestral roles in skeletogenesis and regeneration to putative innovations in fish and birds.

PMID 41782814 · PMC12955574 · iScience · 2026 · 8 claims · 8 setups

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The regeneration-associated axolotl gene is Kazald2, not Kazald1

axolotl jawed kazald cyclostome reciprocal tblastn maximum
NDUFA4L2 regulates the progression and chemotherapy sensitivity of HNSCC by inhibiting PANoptosis.

PMID 41787028 · PMC13087130 · NPJ precision oncology · 2026 · 8 claims · 8 setups

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Elevated NDUFA4L2 expression is associated with poor survival and chemotherapy resistance in HNSCC

carcinoma hnscc cal27 oscc non-negative kaplan-meier western
Autocrine SFRP2 (secreted frizzled related protein 2) enhances lung myofibroblast fibrogenic activity by suppressing PINK1-mediated mitophagy initiation.

PMID 41789512 · PMC13185440 · Autophagy · 2026 · 7 claims · 8 setups

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SFRP2 is specifically highly expressed in myofibroblasts derived from fibrotic (IPF/BLM/TGFB1-induced) lung tissue

lung pmlfs mrc5 single-cell bulk histology
Metabolic Adaptation of CD8⁺ T Cells Limits the Efficacy of Fatty Acid Oxidation Inhibition in Type 1 Diabetes.

PMID 41800251 · PMC12965062 · International journal of biological sciences · 2026 · 8 claims · 8 setups

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TMZ enhances mitochondrial membrane potential and suppresses fatty acid oxidation (FAO) in human T cells

peripheral endoc-βh5 nod pancreatic mitochondrial extracellular glucose-stimulated
SMARCA4/2 loss reduces BCL-xL expression and confers a druggable MCL1 dependency in cancer.

PMID 41807550 · PMC13249849 · NPJ precision oncology · 2026 · 8 claims · 8 setups

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MCL1 inhibition is synthetic lethal with SMARCA4/2 loss in SCCOHT and NSCLC cells

nsclc lung smarca4 bin-67 genome-wide drug colony
HIF3A-mediated aberrant activation of TXNIP promotes Alzheimer's disease progression.

PMID 41807716 · PMC13096512 · Scientific reports · 2026 · 8 claims · 8 setups

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OS activity is significantly elevated in AD and shows pronounced heterogeneity across brain cell types

entorhinal brain middle c57bl scrna-seq bulk animal
Smoking promotes colorectal cancer via the CKAP2L/AREG axis.

PMID 41823522 · PMC13038336 · International journal of oncology · 2026 · 8 claims · 8 setups

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Smoking is positively associated with CRC risk, confirmed by both cross-sectional (NHANES) and Mendelian randomization analyses

participants european crc hct116 cross-sectional two-sample single-cell
CCAAT-enhancer binding protein delta functions as a tumor suppressor gene in acute myeloid leukemia.

PMID 41844049 · PMC13010944 · Neoplasia (New York, N.Y.) · 2026 · 8 claims · 8 setups

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CEBPD is identified as a novel tumor suppressor gene in AML

paired aml tcga oci-aml5 bulk bart kaplan-meier
A differential single-cell transcriptome atlas of left-sided and right-sided colorectal cancer.

PMID 41844817 · PMC13111741 · Discover oncology · 2026 · 8 claims · 8 setups

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MTRNR2L8 is markedly upregulated in RCRC tumor cells and is associated with poorer patient survival

crc epithelial rcrc tcga-read scrna-seq copy gene
Identification and validation of key PANoptosis-related genes via integrative machine learning and single-cell sequencing in AILI.

PMID 41858622 · PMC12995703 · iScience · 2026 · 8 claims · 8 setups

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Cdkn1a and Pdk1 are key PANoptosis-related genes with high diagnostic potential for AILI

liver training bulk wgcna machine
Single point mutations in global regulatory genes restore cephalosporin resistance in a low-MIC Enterococcus faecium natural isolate.

PMID 41870094 · PMC13148053 · Antimicrobial agents and chemotherapy · 2026 · 8 claims · 8 setups

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E. faecium isolates with low MICs to cephalosporins can arise in clinical settings without laboratory manipulation

faecium efm5 antibiotic selection whole-genome
Reduced cartilage matrix stiffness in temporomandibular joint osteoarthritis impairs the functions of superficial zone chondrocytes via downregulation of CREB5-PLPP3 signaling.

PMID 41870835 · PMC13009359 · Molecular biomedicine · 2026 · 7 claims · 8 setups

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ECM stiffness (Young's modulus) is reduced in the superficial zone of condylar cartilage in TMJOA patients and in a rat UAC-induced TMJOA model

condylar szc tmjoa nanoindentation single-cell bulk
Dynamic changes of the immune microenvironment in ovarian cancer following neoadjuvant chemotherapy.

PMID 41872134 · PMC13039919 · Cell death discovery · 2026 · 8 claims · 8 setups

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Prostaglandin-mediated immunosuppressive microenvironment formation is a critical contributor to chemotherapy resistance following cisplatin treatment

high-grade hgsoc bone bmdms scrna-seq cell-cell tensor
The macrophage entry mechanism of SARS-CoV-2 mediated by surface CD98/TMPRSS11E complex is associated with the cellular tropism toward proinflammatory M1 and pathogenesis.

PMID 41877147 · PMC13137717 · Respiratory research · 2026 · 8 claims · 8 setups

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CD98 (CD98hc/SLC3A2) is a novel receptor for the SARS-CoV-2 Spike protein

thp-1-derived 293t structures thp-1 co-ip co-immunoprecipitation molecular
Targeting TPX2-dependent lineage plasticity by CDK4/6 inhibition reverses therapy resistance in neuroendocrine bladder carcinoma.

PMID 41923619 · PMC13130694 · Cell reports. Medicine · 2026 · 8 claims · 8 setups

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A 315-gene 'NE-like signature' (NE-like Sig), derived from the WGCNA MEmidnightblue module, marks a lineage-plasticity-associated transcriptional program distinct from canonical NE differentiation.

cases in-house bladder nebc wgcna single-cell spatial
Aging-dependent microglial heterogeneity worsens outcomes in models of traumatic brain injury.

PMID 41926211 · PMC13262727 · The Journal of clinical investigation · 2026 · 8 claims · 8 setups

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Aged TBI brains predominantly harbor proinflammatory NLRP3+ microglia, whereas young TBI brains harbor neuroprotective Lysozyme+ microglia

injured sorted facs-purified cas9-gfp scrna-seq atac-seq untargeted
Multi-omics integration and machine learning reveal gut-immune signatures in idiopathic pulmonary fibrosis: insights from bulk RNA-seq, single-cell profiles, spatial transcriptomics, and experimental validation.

PMID 41939867 · PMC13043422 · Frontiers in immunology · 2026 · 7 claims · 8 setups

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CXCL13, IL33, TLR4, and IGF1 are core IPF genes consistently linked to immune infiltration and fibrotic remodeling across bulk, single-cell, spatial, and blood multi-omics data

lung candidate bulk normalized bulk ppi machine

Experiments

Cardiac conduction system malformations in heterotaxy result from dysregulated Pitx2 expression.

ASCL1 promotes nuclear shrinkage in transdifferentiation by suppressing NUP37.

Targeting the Lipid Metabolism Proteins FASN and GPAM in Alveolar Type II Cells Decreases Lung Metastasis.

Differential fates of Kazald gene quartet: Ancestral roles in skeletogenesis and regeneration to putative innovations in fish and birds.

NDUFA4L2 regulates the progression and chemotherapy sensitivity of HNSCC by inhibiting PANoptosis.

Autocrine SFRP2 (secreted frizzled related protein 2) enhances lung myofibroblast fibrogenic activity by suppressing PINK1-mediated mitophagy initiation.

Metabolic Adaptation of CD8⁺ T Cells Limits the Efficacy of Fatty Acid Oxidation Inhibition in Type 1 Diabetes.

SMARCA4/2 loss reduces BCL-xL expression and confers a druggable MCL1 dependency in cancer.

HIF3A-mediated aberrant activation of TXNIP promotes Alzheimer's disease progression.

Smoking promotes colorectal cancer via the CKAP2L/AREG axis.

CCAAT-enhancer binding protein delta functions as a tumor suppressor gene in acute myeloid leukemia.

A differential single-cell transcriptome atlas of left-sided and right-sided colorectal cancer.

Identification and validation of key PANoptosis-related genes via integrative machine learning and single-cell sequencing in AILI.

Single point mutations in global regulatory genes restore cephalosporin resistance in a low-MIC Enterococcus faecium natural isolate.

Reduced cartilage matrix stiffness in temporomandibular joint osteoarthritis impairs the functions of superficial zone chondrocytes via downregulation of CREB5-PLPP3 signaling.

Dynamic changes of the immune microenvironment in ovarian cancer following neoadjuvant chemotherapy.

The macrophage entry mechanism of SARS-CoV-2 mediated by surface CD98/TMPRSS11E complex is associated with the cellular tropism toward proinflammatory M1 and pathogenesis.

Targeting TPX2-dependent lineage plasticity by CDK4/6 inhibition reverses therapy resistance in neuroendocrine bladder carcinoma.

Aging-dependent microglial heterogeneity worsens outcomes in models of traumatic brain injury.

Multi-omics integration and machine learning reveal gut-immune signatures in idiopathic pulmonary fibrosis: insights from bulk RNA-seq, single-cell profiles, spatial transcriptomics, and experimental validation.