Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Comparative Genomics Provide Insight Into the Evolution of European Aphanomyces euteiches Strains.

  PMID 41832745 · PMC13044513 · Genome biology and evolution · 2026 · 8 claims · 8 setups

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  Genome-wide SNP data confirm three genetically distinct A. euteiches populations in Europe, with Italian strains forming a clearly separated group

  euteiches aphanomyces ce1 whole-genome busco comparative

• The genome sequence of the flat clown beetle, Hololepta plana (Sulzer, 1776) (Coleoptera: Histeridae).

  PMID 42255359 · PMC13237540 · Wellcome open research · 2026 · 8 claims · 8 setups

  Full-text index only

  A chromosome-level genome assembly was produced for Hololepta plana (icHolPlan1) using the Darwin Tree of Life pipeline

  hololepta head abdomen hifi barcoding pacbio hi-c

• BaRTv2: a highly resolved barley reference transcriptome for accurate transcript-specific RNA-seq quantification.

  PMID 35704392 · PMC9546494 · The Plant journal : for cell and molecular biology · 2022 · 8 claims · 6 setups

  Has reproduction · 94

  BaRTv2.18 is the most comprehensive and resolved reference transcriptome in barley to date, containing 39,434 genes and 148,260 transcripts

  barley pacbio illumina read

• A chromosome-level reference genome and pangenome for barn swallow population genomics.

  PMID 36662619 · PMC10044405 · Cell reports · 2023 · 8 claims · 8 setups

  Full-text index only

  A chromosome-level, karyotype-validated reference genome (bHirRus1) was assembled using the VGP pipeline combining PacBio CLR, 10x Linked-Reads, Bionano optical maps, and Hi-C data

  single barn bhirrus1 rustica genome cytogenetic reference-free

• annotate_my_genomes: an easy-to-use pipeline to improve genome annotation and uncover neglected genes by hybrid RNA sequencing.

  PMID 36472574 · PMC9724561 · GigaScience · 2022 · 7 claims · 8 setups

  Has reproduction · 78

  annotate_my_genomes is an easy-to-use genome-guided pipeline that uses hybrid (PacBio+Illumina) assembled transcripts to distinguish coding genes from long non-coding RNAs and reconcile them with prior annotations.

  chick real simulated pacbio illumina hybrid

• Hybrid sequencing reveals incompleteness of the H37Rv reference genome and highlights lineage-specific genomic divergence in Mycobacterium tuberculosis.

  PMID 42224013 · PMC13225438 · Microbial genomics · 2026 · 8 claims · 6 setups

  Full-text index only

  The H37Rv_ref reference genome, sequenced in 1998 with early technology, is incomplete relative to modern hybrid-sequenced assemblies

  tuberculosis h37rv_cn a2018772 publicly hybrid comparative functional

• Haplotype-resolved and near telomere-to-telomere assembly of the autotetraploid potato genome.

  PMID 41634861 · PMC12955163 · Genome biology · 2026 · 8 claims · 8 setups

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  PHap is a new pipeline that enables haplotype-resolved, near-T2T assembly of autopolyploid genomes using only standard HiFi, ONT-UL, and Hi-C sequencing data

  autotetraploid parental huashu4 pacbio hi-c illumina

• Transcriptome assemblies for two drug-type cannabis chemotypes by long-read RNA sequencing.

  PMID 41968651 · PMC13071343 · The plant genome · 2026 · 8 claims · 7 setups

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  PacBio Iso-Seq transcriptome assemblies were generated for two contrasting drug-type cannabis chemotypes (THC-dominant and CBD-dominant)

  cannabis same pacbio short-read functional

• nf-core/isoseq: simple gene and isoform annotation with PacBio Iso-Seq long-read sequencing.

  PMID 36961337 · PMC10199315 · Bioinformatics (Oxford, England) · 2023 · 7 claims · 4 setups

  Has reproduction · 88

  nf-core/isoseq is a new automated Nextflow-based pipeline that processes raw Iso-Seq subreads through to genome annotation (BED format) without requiring transcriptome assembly.

  organism-specific iso-seq reference mapped pacbio subread long-read

• Chromosome-scale Elaeis guineensis and E. oleifera assemblies: comparative genomics of oil palm and other Arecaceae.

  PMID 38918881 · PMC11373658 · G3 (Bethesda, Md.) · 2024 · 8 claims · 8 setups

  Has reproduction · 81

  Improved E. guineensis genome assembly achieved with substantially increased continuity and completeness compared to prior assemblies

  guineensis oleifera root pacbio proximity optical

• Highly contiguous chromosome-level assembly of the rock goby (Gobius paganellus) genome.

  PMID 41611730 · PMC12957465 · Scientific data · 2026 · 8 claims · 8 setups

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  Chromosome-level genome assembly of Gobius paganellus spans 813 Mb with >99.9% of sequence anchored to 23 pseudochromosomes

  liver eight pacbio soft-masked pacbio hi-c rna-seq

• Characterization of protein isoform diversity in human umbilical vein endothelial cells via long-read proteogenomics.

  PMID 36457147 · PMC9721438 · RNA biology · 2022 · 8 claims · 7 setups

  Has reproduction · 93

  Long-read RNA-seq detected 53,863 transcript isoforms from 10,426 genes in HUVECs, of which 22,195 were novel

  huvecs huvec long-read bottom-up offline

• Accessing medically relevant complex regions with a pangenome graph of 20 near-complete Japanese haplotypes.

  PMID 42203797 · PMC13216315 · Nature communications · 2026 · 8 claims · 8 setups

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  Generated 20 near-complete haplotypes from 10 Japanese male individuals using PacBio HiFi, ONT ultra-long, and Omni-C reads, all with contig N50 exceeding 100 Mbp

  japanese pacbio oxford omni-c

• isoSeQL: comparing long-read isoforms across multiple datasets.

  PMID 41452740 · PMC12790818 · Bioinformatics (Oxford, England) · 2026 · 8 claims · 4 setups

  Full-text index only

  isoSeQL enables comparison of long-read isoform profiles across multiple datasets by consolidating SQANTI3-annotated samples into a unified SQLite database with consistent isoform IDs

  gencode simulated gm12878 peripheral intron simulated long-read

• The chromosomal genome sequence of the sponge Phakellia ventilabrum (Linnaeus, 1767) and its associated microbial metagenome sequences.

  PMID 41625985 · PMC12859430 · Wellcome open research · 2026 · 8 claims · 8 setups

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  The Phakellia ventilabrum genome assembly spans 211.92 Mb with 99.97-99.98% scaffolded into 25 chromosomal pseudomolecules

  phakellia pacbio genome microbial pacbio hi-c sequencing

• FEDRANN: effective long-read overlap detection based on dimensionality reduction and approximate nearest neighbors.

  PMID 42102720 · PMC13201080 · GigaScience · 2026 · 8 claims · 6 setups

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  A pipeline combining IDF transformation, sparse random projection (SRP), and NNDescent (the FEDRANN strategy) enables accurate overlap detection across diverse long-read datasets

  real same chromosome genome overlap exact simulated

• MOSAIK: a hash-based algorithm for accurate next-generation sequencing short-read mapping.

  PMID 24599324 · PMC3944147 · PloS one · 2014 · 8 claims · 8 setups

  Has reproduction · 29

  MOSAIK is the only aligner that consistently aligns reads from all major sequencing platforms (Illumina, AB SOLiD, Roche 454, Ion Torrent, Pacific Biosciences SMRT) using the same algorithmic approach.

  simulated million coli illumina short-read mapping neural-network

• IFDlong: a model-based isoform and fusion detector for accurate annotation and quantification of long-read RNA-seq data.

  PMID 41851882 · PMC13113378 · Genome biology · 2026 · 8 claims · 2 setups

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  IFDlong is the only tool that can discover fusion transcripts at isoform resolution

  in-silico type long-read computational

• Genetic polyploid phasing from low-depth progeny samples.

  PMID 35692633 · PMC9184567 · iScience · 2022 · 8 claims · 7 setups

  Has reproduction · 73

  WH-PPG phases polyploid parental samples by scoring informative variant pairs with a Bayesian log-likelihood model of progeny allele depths, clustering alleles by co-occurrence likelihood, and assigning clusters to haplotypes via interval scheduling

  solanum illumina pacbio wh-ppg

• Determination of complete chromosomal haplotypes by bulk DNA sequencing.

  PMID 33957932 · PMC8101039 · Genome biology · 2021 · 8 claims · 8 setups

  Has reproduction · 97

  A hierarchical computational strategy that first builds high-confidence local haplotype blocks from long-range/linked-read linkage and then concatenates them into whole-chromosome haplotypes using Hi-C contacts

  rpe-1 na12878 aneuploid linked-read hi-c bulk