Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• A Double-Negative Prostate Cancer Subtype Is Vulnerable to SWI/SNF-Targeting Degrader Molecules.

  PMID 41534092 · PMC13044530 · Cancer research · 2026 · 8 claims · 8 setups

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  SWI/SNF-targeting PROTAC treatment reduces viability of CRPC-WNT (AR-negative) cell lines and organoids, not just AR-dependent CRPC

  prostate nsg formalin-fixed patient-derived viability western xenograft

• Ex Vivo Immuno-Oncology Platform Reveals Spatial T-cell Infiltration Patterns Linked to ATR Inhibition Responses in High-Grade Serous Ovarian Cancer.

  PMID 41563843 · PMC7618831 · Cancer immunology research · 2026 · 8 claims · 8 setups

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  iPDCs cultured on human omentum gel (OmGel) recapitulate tumor genomic and histologic characteristics while retaining intratumoral immune cells

  formalin-fixed blood dissociated ipdcs histopathology whole-exome flow

• CRISPR screens in the context of immune selection identify CHD1 and MAP3K7 as mediators of cancer immunotherapy resistance.

  PMID 41564866 · PMC12866162 · Cell reports. Medicine · 2026 · 8 claims · 8 setups

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  CHD1 and MAP3K7 loss additively sensitizes cancer cells to IFN-γ-induced death

  a375 crc-9 ht-29 vcap whole-genome autologous incucyte

• Redefinition of the toll-like receptor repertoire in Ciona robusta through genomic, structural, and expression analyses.

  PMID 41568004 · PMC12816324 · Frontiers in cellular and infection microbiology · 2025 · 8 claims · 8 setups

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  CiTLR13 is a redundant annotation of CiTLR1 (same genomic locus, >94% sequence identity), so it is not a distinct TLR gene

  ciona six lrr tlr blastp domain nucleotide

• Multi-omics profiling reveals microenvironmental remodeling as a key driver of house dust mite-induced lung cancer progression.

  PMID 41610471 · PMC12874334 · Neoplasia (New York, N.Y.) · 2026 · 8 claims · 7 setups

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  Chronic HDM exposure accelerates lung tumor growth through non-mutagenic, immune-mediated mechanisms

  orthotopic lung beas-2b tumor bioluminescence h&e viability

• PolyAseqTrap: a universal tool for genome-wide identification and quantification of polyadenylation sites from different 3' end sequencing data.

  PMID 41620776 · PMC12947541 · Genome biology · 2026 · 6 claims · 7 setups

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  PolyAseqTrap is a universal R package for identifying and quantifying polyA sites from diverse 3' end sequencing data

  species arabidopsis seq polyasite end direct deep

• Maternal Fine Particulate Matter Exposure Impairs Inguinal White Adipose Tissue Plasticity in Middle-Aged Male Mouse Offspring.

  PMID 41648986 · PMC12918713 · ACS nano · 2026 · 7 claims · 8 setups

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  Maternal PM2.5 exposure induces insulin resistance in middle-aged male (but not female) offspring despite normal body weight/obesity status

  pregnant iwat adsc whole-body body histology

• Mitochondrial DNA methylation predicts immunotherapy response and prognosis in lung adenocarcinoma: evidence from scRNA-Seq and machine learning.

  PMID 41663976 · PMC12997902 · BMC cancer · 2026 · 8 claims · 8 setups

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  Differentially expressed MTDM-related genes (DEMTDMRGs) are significantly enriched in cell cycle regulation, ferroptosis, and ABC transporter pathways

  luad demtdmrgs gse131907 wgcna kegg univariate

• A macrophage-induced subpopulation of mesenchymal cells expressing Fcer1g contributes to wound-induced fibrosis.

  PMID 41680182 · PMC13009336 · Nature communications · 2026 · 8 claims · 7 setups

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  Early-phase macrophage depletion (MaFIA + AP20187) reduces fibrosis/scar area and mesenchymal cell numbers without delaying reepithelialization or angiogenesis.

  mafia nih pdgfra-rtta flow excisional immunofluorescence

• Amelioration of colorectal cancer-associated fibroblasts in immunosuppressive microenvironment by ferroptosis-based nanotherapy.

  PMID 41690961 · PMC13018587 · Nature communications · 2026 · 8 claims · 8 setups

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  CAFs drive tumor-promoting activity and immunosuppression, contributing to CRC immunotherapy resistance

  crc patient-derived hct116 models bioinformatic cytotoxicity bio-tem

• The transcription factor EHF promotes the maturation and immunosuppression of conventional dendritic cells.

  PMID 41730908 · PMC13039115 · Nature communications · 2026 · 8 claims · 8 setups

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  EHF orchestrates an immunosuppressive maturation program in cDC1s and cDC2s downstream of TLR7/8/9 sensing of self-nucleic acids

  ehf facs-sorted dss-induced lethal cd4+

• ROR1-PI3K/AKT signaling drives adaptive resistance to cell cycle blockade in TP53 mutated ovarian cancer.

  PMID 41748546 · PMC13004963 · Cell death & disease · 2026 · 7 claims · 8 setups

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  A shared PI3K/AKT-regulated signaling node governs drug adaptation across all long-term resistant (lt-res) ADA and PTX models

  hgsoc kuramochi jhos2 parental long-term inducible overexpression

• Precancerous niche remodelling dictates nascent tumour persistence.

  PMID 41781610 · PMC13148994 · Nature · 2026 · 8 claims · 8 setups

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  Newly emerging tumours actively remodel their surrounding stroma into a 'precancerous niche' that determines their long-term survival.

  upper nascent oesophagus carcinogen-free immunofluorescence edu immune

• Metabolic Adaptation of CD8⁺ T Cells Limits the Efficacy of Fatty Acid Oxidation Inhibition in Type 1 Diabetes.

  PMID 41800251 · PMC12965062 · International journal of biological sciences · 2026 · 8 claims · 8 setups

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  TMZ enhances mitochondrial membrane potential and suppresses fatty acid oxidation (FAO) in human T cells

  peripheral endoc-βh5 nod pancreatic mitochondrial extracellular glucose-stimulated

• miR-203 facilitates timely cell fate transitions via epigenetic modulation during early embryogenesis.

  PMID 41811946 · PMC12978216 · Science advances · 2026 · 8 claims · 8 setups

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  miR-203 is required for a timely totipotency-to-pluripotency transition during early mouse embryogenesis

  preimplantation 8-cell mice mir-203 qrt-pcr genotyping time-lapse

• pmid-41837284

  PMID 41837284 · PMC12987620 · 8 claims · 8 setups

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  Loss of T cell-intrinsic VISTA enhances early priming and short-term expansion of CD8+ T cells but this initial advantage fails to confer durable tumor control

  tumor vsir cell-specific myeloid-specific flow adoptive peptide

• Spns1-dependent endocardial lysosomal function drives valve morphogenesis through Notch1-signaling.

  PMID 39720516 · PMC11667069 · iScience · 2024 · 7 claims · 8 setups

  Has reproduction · 78

  Autophagosomal, autolysosomal, and lysosomal vesicles significantly accumulate in the atrioventricular canal (AVC) and outflow tract (OFT)/bulboventricular regions and their developing valves during zebrafish heart development.

  β-actin2 tgki cmv tgbac light-sheet lysotracker lysosome