Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• NET-prism enables RNA polymerase-dedicated transcriptional interrogation at nucleotide resolution.

  PMID 31156037 · PMC6693550 · RNA biology · 2019 · 8 claims · 7 setups

  Has reproduction · 67

  NET-prism, an adapted NET-seq protocol using immunoprecipitation of Pol II-associated factors, enables strand-specific, nucleotide-resolution interrogation of transcription dynamics for any Pol II-interacting protein.

  e14 mass western net-prism

• Oxidized LDL Induces Pro-Inflammatory Transcriptomic and Epigenomic Responses in Human CD4(+) T Cells.

  PMID 41707046 · PMC12916081 · FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026 · 8 claims · 6 setups

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  Ox-LDL causes a shift toward a pro-inflammatory, cytokine-producing transcriptomic state in activated CD4+ T cells

  activated naïve cd4+ cad rna-sequencing atac-sequencing chip-sequencing

• Genome-wide kinetic properties of transcriptional bursting in mouse embryonic stem cells.

  PMID 32596448 · PMC7299619 · Science advances · 2020 · 8 claims · 8 setups

  Has reproduction · 57

  Transcriptional bursting kinetics is regulated by a combination of promoter- and gene body-binding proteins, including the polycomb repressive complex 2 (PRC2) and transcription elongation factors

  cast knock-in mesc mescs single-cell single-molecule flow

• Dynamic interaction of MYC enhancer RNA with YEATS2 protein regulates MYC gene transcription in pancreatic cancer.

  PMID 40216980 · PMC12117045 · EMBO reports · 2025 · 8 claims · 11 setups

  Has reproduction · 90

  MYC eRNAs (notably MYC-490-kb) are transcribed from the MYC super-enhancer and are upregulated by chronic TNF-α stimulation specifically in pancreatic cancer cells, not normal pancreatic epithelial cells

  pdac miapaca-2 chronic myc-490-kb survival chip-seq nascent

• Bromodomain protein IBD1 bridges histone acetylation and H2A.Z deposition to fine-tune transcription.

  PMID 41728948 · PMC12926916 · Nucleic acids research · 2026 · 8 claims · 8 setups

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  IBD1's bromodomain recognizes H3K9/K14 di-acetylation to recruit the SWR complex subunit ARP6, ensuring precise H2A.Z incorporation into chromatin

  tetrahymena recombinant native cut&tag sequencing

• Spatially clustered loci with multiple enhancers are frequent targets of HIV-1 integration.

  PMID 31492853 · PMC6731298 · Nature communications · 2019 · 8 claims · 8 setups

  Has reproduction · 77

  Recurrently targeted HIV-1 integration genes (RIGs) are proximal to super-enhancer (SE) genomic elements

  activated cd4+ cd3 jurkat chip-seq hiv-1 sequencing

• AGPAT3 reshapes tumor cell vulnerability to IFNγ-mediated ferroptosis and enhances immunotherapy efficacy through lipid remodeling.

  PMID 41807033 · PMC12983827 · Journal for immunotherapy of cancer · 2026 · 8 claims · 8 setups

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  A ferroptosis-driver gene signature (FD.sig) and machine learning model (FD.model) can predict ICI response

  pan-cancer tcga a375 machine single-cell bulk

• Stage- and cluster-specific regulation of chondrogenic gene programs by Sox9 in mouse embryonic limb buds.

  PMID 41809054 · PMC12969044 · iScience · 2026 · 8 claims · 7 setups

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  scRNA-seq across five limb bud stages identifies four Sox9-high populations (chondroprogenitors 1, 2, 3, and mature chondrocytes) with distinct temporal dynamics

  forelimb scrna-seq cut&run embryo single-cell cut&run velocity

• Characterizing natural variation using next-generation sequencing technologies.

  PMID 19801172 · PMC3994700 · Trends in genetics : TIG · 2009 · 8 claims · 8 setups

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  Next-generation sequencing enables complete, genome-wide surveys of genetic variation at unprecedented resolution, overcoming limitations of genotyping panels and microarrays.

  pichia individuals saccharomyces individual whole-genome partial comparative

• Effector gene silencing coordinated by histone methylation and small RNAs enhances host adaptation in a plant pathogen.

  PMID 41505097 · PMC12781887 · Nucleic acids research · 2026 · 8 claims · 8 setups

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  CRISPR/Cas9 editing of PsSu(z)12 abolishes H3K27me3 deposition at Avr1b and Avr3a, causing transcriptional reactivation and loss of avirulence

  sojae soybean crispr homology-directed virulence

• Identification of new ETV6 modulators through a high-throughput functional screening.

  PMID 35198911 · PMC8851229 · iScience · 2022 · 7 claims · 8 setups

  Has reproduction · 68

  A genome-wide shRNA screen in an engineered ETV6-dependent Blasticidin-sensitive pre-B ALL cell line can identify modulators of ETV6 repressive transcriptional activity

  reh genome-wide qrt-pcr chip-seq

• MECOM Function Is Critical for AR-Driven Treatment-Resistant Prostate Cancer.

  PMID 41529070 · PMC13136877 · Cancer research · 2026 · 7 claims · 8 setups

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  EVI1, encoded by MECOM, is an AR-recruited coactivator of noncanonical AR signaling in prostate cancer.

  lrex lucap167 prostate live-cell spheroid patient-derived

• Epimutations driven by RNAi or heterochromatin evoke transient antimicrobial drug resistance in pathogenic Mucor fungi.

  PMID 41628159 · PMC12863538 · PLoS biology · 2026 · 8 claims · 8 setups

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  In M. bainieri, most (90%) FK506-resistant isolates are unstable/transient and revert to drug sensitivity without any detectable DNA mutation

  mucor fk506-resistant bainieri drug sanger serial

• Nonsense-mediated mRNA decay orchestrates neuronal migration and cortical lamination while modulating Reelin and ciliary gene regulatory networks.

  PMID 41746809 · PMC13042203 · Cell reports · 2026 · 8 claims · 8 setups

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  UPF2-mediated NMD is required for proper cortical lamination; conditional Upf2 deletion in radial glia disrupts layering of TBR1+/SATB2+ and CTIP2+/CUX1+ neurons.

  cortex embryonic cortical neural immunofluorescence utero co-electroporation