Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 14

System / cell line: expression ✕ Assay: rnascope ✕ Clear

Spatiotemporal transcriptomic profiling reveals upregulation of glycolysis pathway genes before overt tauopathy in the PS19 mouse model.

PMID 41688738 · PMC12992590 · Experimental & molecular medicine · 2026 · 7 claims · 7 setups

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Pgk1, a glycolytic hub gene, is upregulated in the CA3 hippocampal subregion at 2 months of age, preceding detectable tau tangle pathology, and its expression correlates with tangle severity.

ps19 spatial immunohistochemistry immunofluorescence
auts2 Features and Expression Are Highly Conserved during Evolution Despite Different Evolutionary Fates Following Whole Genome Duplication.

PMID 36078102 · PMC9454499 · Cells · 2022 · 8 claims · 7 setups

Has reproduction · 50

auts2a and auts2b originate from the teleost-specific whole genome duplication (TGD)

fish genomic auts2 tissues comparative tblastn phylogenetic
The transcription factor HHEX maintains glucocorticoid levels and protects adrenals from androgen-induced lipid depletion.

PMID 41519914 · PMC12891536 · Nature communications · 2026 · 8 claims · 8 setups

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HHEX is the most enriched transcription factor in glucocorticoid-producing zona fasciculata (zF) cells, conserved across mouse, rat, and human adrenal

sf1-cre-high adrenocortical scrna-seq rnascope immunohistochemistry
Single-cell and spatial transcriptomic profiling of cardiac fibroblasts following myocardial infarction.

PMID 41526391 · PMC12890913 · Scientific data · 2026 · 7 claims · 6 setups

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Cthrc1+ Reparative Cardiac Fibroblasts (RCFs) are the primary driver of the cardiac healing process after myocardial infarction

col1α1-gfp+ heart frozen bulk single-cell spatial
Small molecule inhibition rescues the skeletal dysplasia phenotype of Trpv4 mutant mice.

PMID 41574606 · PMC12892883 · JCI insight · 2026 · 8 claims · 8 setups

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Chondrocyte-specific (Col2a1-Cre-driven) expression of the p.R594H Trpv4 mutation reproduces the human TRPV4 skeletal dysplasia phenotype in mice, including short stature, long bone and craniofacial abnormalities, and vertebral defects.

col2a1-cre proximal growth cervical radiography histology rnascope
HIF sustain a transcriptional regulatory circuit of EPAS1 expression in renal clear cell carcinoma.

PMID 41714613 · PMC12921326 · Nature communications · 2026 · 8 claims · 8 setups

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HIF-2α mRNA is specifically overexpressed in ccRCC tumor tissue/cells compared to normal kidney, while it is reduced in papillary and chromophobe RCC

erlangen tcga ccrcc tubule qpcr rna-seq rnascope
Heterozygous ADAR mutant mice exhibit RNA sensing-dependent neuroinflammation and phenotypes associated with Aicardi-Goutières syndrome.

PMID 41704749 · PMC12907846 · iScience · 2026 · 8 claims · 8 setups

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A heterozygous Adar G1007R (mouse G956R/G567) mouse model recapitulates the genetic and inflammatory features of human ADAR G1007R AGS patients

brain computational coronal adar1 real-time bulk ingenuity
Clonal dynamics shaped by diverse drug-tolerant persister states in melanoma resistance.

PMID 41776501 · PMC13162433 · Molecular cancer · 2026 · 8 claims · 6 setups

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MeRLin, a single-vector high-complexity lineage tracing platform integrating cellular barcoding, scRNA-seq, RNA-FISH, and computational analysis, was developed to track clonal and transcriptional dynamics in a melanoma PDX model

wm4237-1 nsg bulk scrna-seq clonal
Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice.

PMID 40629142 · PMC12321585 · Nature neuroscience · 2025 · 8 claims · 8 setups

Has reproduction · 82

Ganglionic eminence (ventral) progenitors maintain stable differentiation competence throughout neurogenesis, generating a consistent set of postmitotic precursor states at all stages, unlike dorsal cortical progenitors whose differentiation competence changes gradually.

dlx5 progenitors sections cortical scrna-seq trackerseq flashtag
A Plastic EMP1+ to LGR5+ Cell State Conversion as a Bypass to KRASG12D Pharmacologic Inhibition in Metastatic Colorectal Cancer.

PMID 41128661 · PMC12877754 · Cancer discovery · 2026 · 8 claims · 8 setups

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RMC-9945 exerts durable antitumor activity in early-stage liver metastasis but has diminished therapeutic effect in advanced metastatic disease

aktp colorectal drug single-cell rnascope
α4 Integrin blockade impairs CD8+ T cell neuroimmune surveillance following SIV infection.

PMID 41734020 · PMC13078879 · The Journal of clinical investigation · 2026 · 8 claims · 8 setups

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α4 blockade preserves CD4+ Th1 cell access to brain parenchyma but impairs CD8 effector recruitment, disrupting antiviral control

siv-infected live macaque cd4-δitga4 flow antibody single-cell
Splicing variants in MYRF cause partial loss of function in the retinal pigment epithelium leading to nanophthalmos.

PMID 41746734 · PMC13043084 · JCI insight · 2026 · 8 claims · 8 setups

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The dG-MYRF C-terminal frameshift variant undergoes normal homotrimerization, cleavage, and nuclear localization but shows reduced steady-state levels of the C-terminal cleavage product and decreased transcriptional activation of target genes.

arpe-19 myrf rpe e17.5 immunofluorescence computational cycloheximide
Lung scRNA-seq reveals chronic inflammation and emphysemous phenotype in mice with osteogenesis imperfecta.

PMID 41822759 · PMC12978693 · Frontiers in genetics · 2026 · 8 claims · 3 setups

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Aga2 mice show increased alveolar spacing (emphysematous phenotype) at postnatal day 28 (p28) but not at p5

lung histology single-cell rnascope
iBRIDGE: A Data Integration Method to Identify Inflamed Tumors from Single-cell RNA-Seq Data and Differentiate Cell Type-Specific Markers of Immune-Cell Infiltration.

PMID 37023414 · PMC10236149 · Cancer immunology research · 2023 · 8 claims · 8 setups

Has reproduction · 94

Malignant cells cluster by patient in scRNA-seq data while immune and stromal cells cluster by cell type, making malignant cells uniquely suited to carry patient-level inflamed/cold signal

nsclc coad brca tcga scrna-seq bulk rna-seq

Experiments

Spatiotemporal transcriptomic profiling reveals upregulation of glycolysis pathway genes before overt tauopathy in the PS19 mouse model.

auts2 Features and Expression Are Highly Conserved during Evolution Despite Different Evolutionary Fates Following Whole Genome Duplication.

The transcription factor HHEX maintains glucocorticoid levels and protects adrenals from androgen-induced lipid depletion.

Single-cell and spatial transcriptomic profiling of cardiac fibroblasts following myocardial infarction.

Small molecule inhibition rescues the skeletal dysplasia phenotype of Trpv4 mutant mice.

HIF sustain a transcriptional regulatory circuit of EPAS1 expression in renal clear cell carcinoma.

Heterozygous ADAR mutant mice exhibit RNA sensing-dependent neuroinflammation and phenotypes associated with Aicardi-Goutières syndrome.

Clonal dynamics shaped by diverse drug-tolerant persister states in melanoma resistance.

Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice.

A Plastic EMP1+ to LGR5+ Cell State Conversion as a Bypass to KRASG12D Pharmacologic Inhibition in Metastatic Colorectal Cancer.

α4 Integrin blockade impairs CD8+ T cell neuroimmune surveillance following SIV infection.

Splicing variants in MYRF cause partial loss of function in the retinal pigment epithelium leading to nanophthalmos.

Lung scRNA-seq reveals chronic inflammation and emphysemous phenotype in mice with osteogenesis imperfecta.

iBRIDGE: A Data Integration Method to Identify Inflamed Tumors from Single-cell RNA-Seq Data and Differentiate Cell Type-Specific Markers of Immune-Cell Infiltration.