Experiments
Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).
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Small molecule inhibition rescues the skeletal dysplasia phenotype of Trpv4 mutant mice.
PMID 41574606 · PMC12892883 · JCI insight · 2026 · 8 claims · 8 setups
Chondrocyte-specific (Col2a1-Cre-driven) expression of the p.R594H Trpv4 mutation reproduces the human TRPV4 skeletal dysplasia phenotype in mice, including short stature, long bone and craniofacial abnormalities, and vertebral defects.
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HIF sustain a transcriptional regulatory circuit of EPAS1 expression in renal clear cell carcinoma.
PMID 41714613 · PMC12921326 · Nature communications · 2026 · 8 claims · 8 setups
HIF-2α mRNA is specifically overexpressed in ccRCC tumor tissue/cells compared to normal kidney, while it is reduced in papillary and chromophobe RCC
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Has reproduction · 94
iBRIDGE: A Data Integration Method to Identify Inflamed Tumors from Single-cell RNA-Seq Data and Differentiate Cell Type-Specific Markers of Immune-Cell Infiltration.
PMID 37023414 · PMC10236149 · Cancer immunology research · 2023 · 8 claims · 8 setups
Malignant cells cluster by patient in scRNA-seq data while immune and stromal cells cluster by cell type, making malignant cells uniquely suited to carry patient-level inflamed/cold signal
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Clonal dynamics shaped by diverse drug-tolerant persister states in melanoma resistance.
PMID 41776501 · PMC13162433 · Molecular cancer · 2026 · 8 claims · 6 setups
MeRLin, a single-vector high-complexity lineage tracing platform integrating cellular barcoding, scRNA-seq, RNA-FISH, and computational analysis, was developed to track clonal and transcriptional dynamics in a melanoma PDX model