Experiments
Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).
-
Has reproduction · 75
Frequency and patterns of ribonucleotide incorporation around autonomously replicating sequences in yeast reveal the division of labor of replicative DNA polymerases.
PMID 34551434 · PMC8501979 · Nucleic acids research · 2021 · 6 claims · 4 setups
rNTP incorporation is preferentially found on the leading strand in yeast cells expressing wild-type replicative DNA polymerases
-
Has reproduction · 74
Disome-seq reveals widespread ribosome collisions that promote cotranslational protein folding.
PMID 33402206 · PMC7784341 · Genome biology · 2021 · 8 claims · 8 setups
Disome-seq sequences mRNA fragments protected by two stacked (collided) ribosomes, detecting ribosome collisions at codon resolution.
-
Has reproduction · 85
The exonuclease Xrn1 activates transcription and translation of mRNAs encoding membrane proteins.
PMID 30899024 · PMC6428865 · Nature communications · 2019 · 7 claims · 8 setups
Xrn1 promotes translation of a specific group of mRNAs encoding membrane/secretome proteins, acting at translation initiation.
-
Has reproduction · 76
Estimation of peptide elongation times from ribosome profiling spectra.
PMID 33885812 · PMC8136808 · Nucleic acids research · 2021 · 7 claims · 4 setups
A maximum likelihood statistical model using 915 context-defining parameters can neutralize technical biases (e.g. RNase cleavage preferences) in Ribo-Seq data and estimate peptide elongation times at single-codon resolution.