Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• The genetic basis for DNA methylation variation across tissues and development.

  PMID 41980926 · PMC13254082 · Nature communications · 2026 · 8 claims · 8 setups

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  Strain-specific DMRs between mouse strains are associated with nearby sequence polymorphisms that disrupt TF binding motifs

  cerebellum liver embryo ctcf rrbs wgbs motif

• TiSMeD: A tissue-specific methylation and expression database for biomarker and translational applications.

  PMID 41883585 · PMC13011251 · Molecular therapy. Nucleic acids · 2026 · 8 claims · 8 setups

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  TiSMeD integrates 6,782 methylomes, 16,894 transcriptomes, and 241 proteomes across 48 normal human tissues into a searchable database

  normal plasma case-control tcga methylation transcriptome proteomics

• Commonalities in gene expression and methylation changes across two rat models of acquired epilepsy.

  PMID 41530481 · PMC12877007 · Scientific reports · 2026 · 7 claims · 8 setups

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  71 genes show concordant (same-direction) expression changes and 94 genes show concordant methylation changes across both the kindling and kainic acid epilepsy models

  hippocampus sequencing reduced-representation rt-pcr

• Multi-omic identification of key transcriptional regulatory programs during endurance exercise training in rats.

  PMID 41862462 · PMC13168590 · Nature communications · 2026 · 8 claims · 7 setups

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  Gene regulatory responses to endurance exercise training (EET) are predominantly tissue-specific rather than shared across tissues

  tissues same skm-gn rna-seq atac-seq rrbs

• DMN-seq enriches DNA hypomethylated regions for biomarker discovery using 5-methylcytosine glycosylase.

  PMID 41673887 · PMC13097799 · Genome biology · 2026 · 8 claims · 9 setups

  Has reproduction · 80

  DMN-seq (DMN+) uses DME to nick DNA specifically at 5mC sites, enabling 5mC detection at single-base resolution via selective adaptor ligation

  synthetic partially embryonic mesc glycosylase dmn-seq ultrafast