Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• High-resolution metagenomic reconstruction of the freshwater spring bloom.

  PMID 36698172 · PMC9878933 · Microbiome · 2023 · 8 claims · 8 setups

  Has reproduction · 69

  High-frequency metagenomic sampling (57 samples, 3 filter sizes, 2 depths, 37 days) recovers thousands of prokaryotic, eukaryotic, and viral genomes tracking spring bloom succession in fine detail

  freshwater phytoplankton heterotrophic reservoir 16s 18s shotgun

• Niche Modification by Sulfate-Reducing Bacteria Drives Microbial Community Assembly in Anoxic Marine Sediments.

  PMID 36988509 · PMC10128000 · mBio · 2023 · 7 claims · 7 setups

  Has reproduction · 100

  SRB modify niches (e.g., pH) to affect species coexistence during organic matter degradation

  coastal marine marinilabiliales srb-inhibited 16s molecular physicochemical

• Metabolic features that select for Bathyarchaeia in modern ferruginous lacustrine subsurface sediments.

  PMID 39660009 · PMC11631310 · ISME communications · 2024 · 8 claims · 8 setups

  Has reproduction · 50

  Microbial assemblages shift with depth from iron- and sulfate-reducing bacteria to fermentative anaerobes and methanogens, with Bathyarchaeia selected below the sulfate reduction zone as cell densities exponentially decrease

  sediment freeze-dried pore fixed 16s shotgun bulk

• Spatial patterns of benthic biofilm diversity among streams draining proglacial floodplains.

  PMID 36003939 · PMC9393633 · Frontiers in microbiology · 2022 · 7 claims · 8 setups

  Has reproduction · 95

  Benthic biofilms in tributaries develop higher biomass than those in glacier-fed streams along the lateral chronosequence

  benthic lyophilized streamwater 16s 18s flow

• Sequencing of 16S rRNA gene: a rapid tool for identification of Bacillus anthracis.

  PMID 12396926 · PMC2730316 · Emerging infectious diseases · 2002 · 7 claims · 4 setups

  Full-text index only

  All 86 B. anthracis isolates tested share an identical 16S rRNA gene sequence, designated 16S type 6

  bacillus clinical additional 16s nested comparative

• Use of pyrosequencing and DNA barcodes to monitor variations in Firmicutes and Bacteroidetes communities in the gut microbiota of obese humans.

  PMID 19046425 · PMC2625370 · BMC genomics · 2008 · 6 claims · 7 setups

  Full-text index only

  Identified a 12-bp Bacteroidetes DNA barcode and a 26-bp degenerate Firmicutes DNA barcode within the 16S rRNA gene

  16s brain cystic caecal barcode 16s metagenome

• Prevalence of A2143G mutation of H. pylori-23S rRNA in Chinese subjects with and without clarithromycin use history.

  PMID 18507832 · PMC2427034 · BMC microbiology · 2008 · 7 claims · 6 setups

  Full-text index only

  A2143G point mutation of the H. pylori 23S rRNA gene causes clarithromycin resistance

  fasting subjects serum pylori pcr 13c-urea elisa

• The effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic mice.

  PMID 20368178 · PMC2894525 · Science translational medicine · 2009 · 7 claims · 6 setups

  Full-text index only

  Germ-free C57BL/6J mice can be stably and heritably colonized with a human fecal microbiota, reproducing much of the donor's bacterial diversity.

  fecal postnatal luminal pooled 16s shotgun body

• An intergenic non-coding rRNA correlated with expression of the rRNA and frequency of an rRNA single nucleotide polymorphism in lung cancer cells.

  PMID 19838300 · PMC2759515 · PloS one · 2009 · 8 claims · 7 setups

  Full-text index only

  An nc-rRNA is transcribed from the intergenic spacer upstream of the rRNA transcription start site in human lung epithelial and lung cancer cells, spanning roughly -1000 to at least +203/+300.

  lung hpl1d rrna external pcr rt-pcr quantitative

• Metagenomic study of the oral microbiota by Illumina high-throughput sequencing.

  PMID 19796657 · PMC3568755 · Journal of microbiological methods · 2009 · 8 claims · 6 setups

  Full-text index only

  The 16S rRNA V5 hypervariable region, amplified as a short ~82-base segment, provides reliable taxonomic identification of oral bacteria against public databases like HOMD.

  pooled 16s sequenced topo 16s primer taxonomic

• Elevated phenylacetylglutamine caused by gut dysbiosis associated with type 2 diabetes increases neutrophil extracellular traps formation and exacerbates brain infarction.

  PMID 40471587 · PMC12599254 · Clinical science (London, England : 1979) · 2025 · 7 claims · 8 setups

  Full-text index only

  Plasma PAGln levels are significantly higher in ischemic stroke patients with T2D than in those without T2D

  fecal plasma sprague-dawley cerebral 16s metagenome targeted

• Seasonal Dynamics Are the Major Driver of Microbial Diversity and Composition in Intensive Freshwater Aquaculture.

  PMID 34248892 · PMC8264503 · Frontiers in microbiology · 2021 · 7 claims · 6 setups

  Full-text index only

  Natural seasonality is the primary driver of aquatic bacterial community structure in the fishponds and reservoir

  pond filtered phytoplankton common 16s photosynthetic inorganic

• From forest to farm: the impact of a broad spectrum of lifestyles on the porcine gut microbiota.

  PMID 41810129 · PMC12969317 · Current research in microbial sciences · 2026 · 8 claims · 6 setups

  Full-text index only

  Dietary variables had the largest effect on microbiota composition among lifestyle factors tested

  faecal 16s microbiota 16s volatile faecal

• Impact of differential dietary concentrations of cobalt, manganese and zinc on gastrointestinal microbiome and resistome of lactating dairy cattle.

  PMID 41882801 · PMC13137713 · Animal microbiome · 2026 · 8 claims · 4 setups

  Full-text index only

  Surplus TM feeding did not significantly affect overall microbial diversity (richness, phylogenetic diversity, evenness) in any sampled matrix

  rumen pooled dietary 16s shotgun droplet

• Dual-platform metagenomic surveillance distinguishes pathogen and resistome hotspots across agricultural and mixed-use watersheds.

  PMID 41890980 · PMC13015239 · One health (Amsterdam, Netherlands) · 2026 · 8 claims · 7 setups

  Full-text index only

  Agricultural drainage ditches consistently harbor higher fecal-associated bacterial diversity than mixed-use or forested sites, with pronounced seasonal shifts (higher during spring/fall high-flow periods).

  surface shotgun trimmed co-assembled 16s shotgun short-read

• Standing on the shoulders of microbes: microbiome thermal priming buffers the effects of heatwaves on clams by preventing stress overreaction.

  PMID 41987828 · PMC13077298 · ISME communications · 2026 · 8 claims · 5 setups

  Full-text index only

  Transplantation of a microbiome from heat-primed donor clams into non-acclimated recipients is sufficient to enhance host resilience during a subsequent simulated heatwave.

  ruditapes philippinarum 16s host enzymatic

• Taxonomic description of cyanobacteria from extreme habitats through genome-based classification.

  PMID 42131214 · PMC13161053 · Frontiers in microbiology · 2026 · 8 claims · 7 setups

  Full-text index only

  Cyanobacteria dominate the microbial communities of Hawaiian steam vent habitats, with community composition varying by microhabitat

  environmental steam assembled cyanobacterial 16s metagenome genome

• Tourmaline: A containerized workflow for rapid and iterable amplicon sequence analysis using QIIME 2 and Snakemake.

  PMID 35902092 · PMC9334028 · GigaScience · 2022 · 8 claims · 1 setups

  Has reproduction · 61

  Tourmaline is a Python-based workflow that implements QIIME 2 using the Snakemake workflow management system to automate amplicon sequence analysis.

  bacterial 16s

• Taxonomic and Functional Assessment of Microbial Communities in Urban Runoff-Contaminated Mangrove Sediments.

  PMID 41991668 · PMC13086700 · Current microbiology · 2026 · 7 claims · 7 setups

  Full-text index only

  Colhereiro mangrove shows more pronounced signatures of chronic urban pollution than Araçá Bay, including elevated macronutrients and enrichment of sulfur-metabolizing bacteria and Arcobacter

  mangrove pooled bacterial selected 16s sediment bacterial

• eDNAmap: A Metabarcoding Web Tool for Comparing Marine Biodiversity, With Special Reference to Teleost Fish.

  PMID 41189540 · PMC12627913 · Molecular ecology resources · 2026 · 6 claims · 5 setups

  Has reproduction · 59

  eDNAmap is a web-based platform that stores marine eDNA metabarcoding data and lets users plot sampling locations, generate heatmaps, and run nMDS/cluster analyses on uploaded or database species/ASV composition data.

  teleost dinoflagellates 12s asv edna blast phylogenetic