Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• In vivo dual RNA-Seq uncovers key effectors of epithelial barrier disruption by an extracellular pathogen.

  PMID 41634022 · PMC12966279 · Nature communications · 2026 · 8 claims · 8 setups

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  Dual RNA-Seq of L. interrogans-infected hamsters reveals the in vivo host-pathogen transcriptomic landscape during infection

  golden interrogans hamster epithelial dual rna-seq qpcr

• Identification and validation of key PANoptosis-related genes via integrative machine learning and single-cell sequencing in AILI.

  PMID 41858622 · PMC12995703 · iScience · 2026 · 8 claims · 8 setups

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  Cdkn1a and Pdk1 are key PANoptosis-related genes with high diagnostic potential for AILI

  liver training bulk wgcna machine

• A Plastic EMP1+ to LGR5+ Cell State Conversion as a Bypass to KRASG12D Pharmacologic Inhibition in Metastatic Colorectal Cancer.

  PMID 41128661 · PMC12877754 · Cancer discovery · 2026 · 8 claims · 8 setups

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  RMC-9945 exerts durable antitumor activity in early-stage liver metastasis but has diminished therapeutic effect in advanced metastatic disease

  aktp colorectal drug single-cell rnascope

• Irisin ameliorates obesity and insulin resistance via adipose tissue IL-33 and regulatory T cells.

  PMID 41933175 · PMC13052164 · Nature metabolism · 2026 · 8 claims · 8 setups

  Has reproduction · 48

  Irisin modulates adipose tissue inflammation by increasing IL-33 production and preserving ST2+ regulatory T cells in white adipose tissues, thereby improving obesity and glucose intolerance.

  4-week-old hfd-fed bat iwat aav8-mediated body intraperitoneal

• Identification and validation of prognostic genes related to glycolysis and M2 macrophage in hepatocellular carcinoma: an integrated analysis of bulk RNA sequencing and single-cell RNA sequencing.

  PMID 41766871 · PMC12935947 · Frontiers in immunology · 2026 · 8 claims · 8 setups

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  52 candidate genes were identified at the intersection of glycolysis-related genes (GRGs), M2 macrophage-related genes (MRGs), and HCC-vs-control DEGs (DEGs2).

  tcga-lihc gse149614 key hcc bulk immune cox

• BCAT1-dependent HIF-1α stabilization is a targetable metabolic vulnerability in hepatocellular carcinoma.

  PMID 42061407 · PMC13198305 · Cell reports. Medicine · 2026 · 7 claims · 8 setups

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  BCAT1 depletes α-KG to inhibit PHD and stabilize HIF-1α under hypoxic conditions in HCC

  mhcc97l capillary western bulk

• Histone methyl-transferase G9a inhibition boosts the efficacy of immune checkpoint inhibitors in experimental hepatocellular carcinoma.

  PMID 41923620 · PMC13130624 · Cell reports. Medicine · 2026 · 7 claims · 8 setups

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  G9a expression inversely correlates with gene signatures predictive of favorable ICI response across multiple HCC patient cohorts

  tcga advanced nm53 plc bulk single-cell rt-qpcr