Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• CSsingle: a unified tool for robust decomposition of bulk and spatial transcriptomic data across diverse single-cell references.

  PMID 42080261 · PMC13136905 · Nucleic acids research · 2026 · 8 claims · 8 setups

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  CSsingle explicitly corrects for cell-type-specific RNA content (cell size) differences using ERCC spike-ins or a novel computational estimator

  blood breast developing colorectal bulk scrna-seq spatial

• Decoding drug-responsive cell subpopulations in triple-negative breast cancer using single-cell multiomics.

  PMID 42088352 · PMC13138057 · iScience · 2026 · 8 claims · 8 setups

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  A multimodal framework bridging bulk and single-cell transcriptomics data identifies drug-responsive cell subpopulations in TNBC

  tnbc tcga mdamb453 hcc1937 bulk scrna-seq crispr

• EMTscore infers divergent EMT pathways from omics data and enables rapid screening for EMT-associated gene sets.

  PMID 42097304 · PMC13186194 · Bioinformatics (Oxford, England) · 2026 · 8 claims · 4 setups

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  EMTscore is an R package providing efficient, unbiased scoring of multiple EMT pathways from single-cell or bulk omics data

  small a549 trunk bulk scrna-seq

• Protocol for single-cell optimization objective and trade-off inference.

  PMID 41790544 · PMC12992945 · STAR protocols · 2026 · 6 claims · 6 setups

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  SCOOTI is a computational framework that integrates bulk and single-cell omics data with genome-scale metabolic modeling to infer metabolic objectives and trade-offs

  mcf10a serum-starved contact-inhibited zygote bulk scrna-seq genome-scale

• FAM3C/ILEI protein is elevated in psoriatic lesions and triggers psoriasiform hyperproliferation in mice.

  PMID 37226685 · PMC10331587 · EMBO molecular medicine · 2023 · 8 claims · 8 setups

  Has reproduction · 83

  ILEI protein, but not mRNA, is elevated in psoriatic skin and correlates with disease severity

  skin full-thickness normal k5-ileiind immunohistochemistry scrna-seq bulk

• comBO: A combined human bone and lympho-myeloid bone marrow organoid for preclinical modeling of hematopoietic disorders.

  PMID 41734765 · PMC7618947 · Cell stem cell · 2026 · 8 claims · 8 setups

  Has reproduction · 65

  comBO is a single iPSC-derived organoid differentiation that generates osteolineage, vascular, lymphoid, and myeloid compartments together

  hipsc-derived combo combo-derived healthy-donor flow single-cell confocal

• Pan-cancer evaluation of regulated cell death to predict overall survival and immune checkpoint inhibitor response.

  PMID 38538696 · PMC10973470 · NPJ precision oncology · 2024 · 8 claims · 8 setups

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  RCD score, defined as the sum of ssGSEA scores of 18 RCD signatures, quantifies overall RCD signaling in a sample

  tcga gtex scrna-seq cancer bulk scrna-seq transcriptomic

• A Transcriptional Map of Human Tonsil Architecture: Beyond the Sum of (Single Cell) Parts.

  PMID 41518352 · PMC12790319 · European journal of immunology · 2026 · 8 claims · 5 setups

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  Imaging-based spatial transcriptomics (CosMx SMI) captures tissue complexity and cellular composition more faithfully than scRNA-seq

  palatine same tonsil cosmx imaging-based immunofluorescence scrna-seq

• omnideconv: a unifying framework for using and benchmarking single-cell-informed deconvolution of bulk RNA-seq data.

  PMID 41582216 · PMC12837286 · Genome biology · 2026 · 8 claims · 6 setups

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  omnideconv is an R package providing a unified interface to twelve second-generation deconvolution methods (AutoGeneS, BayesPrism, Bseq-SC, Bisque, CDseq, CIBERSORTx, CPM, DWLS, MOMF, MuSiC, SCDC, Scaden)

  blood-derived pbmc blood spleen bulk scrna-seq pseudo-bulk

• Protocol to perform cell-type-specific transcriptome-wide association study using scPrediXcan framework.

  PMID 41689808 · PMC12925207 · STAR protocols · 2026 · 6 claims · 6 setups

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  scPrediXcan enables cell-type-specific transcriptome-wide association studies (TWAS) by integrating deep learning-based prediction of gene expression from DNA sequence and epigenetic features.

  acinar individual-level geuvadis beta mlp-based personalized elastic-net

• Uropathogenic Escherichia coli invade luminal prostate cells via FimH-PPAP receptor binding.

  PMID 41507584 · PMC12872464 · Nature microbiology · 2026 · 8 claims · 8 setups

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  A 2D mouse stem cell-derived prostate epithelial organoid model was developed that mimics epithelial heterogeneity of the murine prostate

  prostate bladder immunofluorescence single-cell transepithelial

• PRDM1+ Malignant Cells Mediate an Immunosuppressive Landscape and Resistance to Neoadjuvant Chemoradiotherapy and Immunotherapy in Esophageal Squamous Cell Carcinoma.

  PMID 41556358 · PMC13042517 · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026 · 8 claims · 8 setups

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  A PRDM1+ malignant epithelial cell subcluster (Epi_C4) is enriched in NMPR patients and is associated with nICRT treatment resistance

  locally escc pd-1 kyse-30 single-arm scrna-seq bulk

• Spatial transcriptomics reveals altered communities and drivers of aberrant epithelia and pro-fibrotic fibroblasts in interstitial lung diseases.

  PMID 41576947 · PMC12985369 · Cell genomics · 2026 · 7 claims · 7 setups

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  snRNA-seq census of 227,680 nuclei across 48 cell types reveals altered cellular states and compositional rewiring of the distal lung in ILD

  frozen lung flash-frozen spatial single-nucleus scrna-seq 10x

• Sex-Based Differences in Cell Types and Gene Expression within the Anterior Cruciate Ligament.

  PMID 41587266 · PMC13011956 · The Journal of bone and joint surgery. American volume · 2026 · 8 claims · 5 setups

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  ACL tissue is heterogeneous, containing 5 major cell types: fibroblasts, pericytes, endothelial cells, macrophages, and T cells.

  acl differentially study flow single-cell immunofluorescence

• FOXA1 mutations co-opt nascent transcription factor networks in partnership with androgen receptor to enhance prostate tumorigenicity.

  PMID 41621066 · PMC13050545 · Cell reports · 2026 · 8 claims · 8 setups

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  FOXA1 mutations in a 874-tumor cohort cluster into missense, in-frame indel, and truncation subgroups, with indels concentrated at residues M253/E255

  prostate targeted single-nucleus scatac-seq

• Single-nucleus multiple-organ chromatin accessibility landscape in the adult rat.

  PMID 41632074 · PMC12954174 · GigaScience · 2026 · 8 claims · 5 setups

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  Generated a multi-organ snATAC-seq atlas of 9 adult rat organs comprising 25 libraries and over 110,000 cells

  organs publicly snatac-seq group-level snatac-seq scrna-seq gene

• Dextrorotatory kynurenine suppresses acute rejection through inhibiting M1 macrophage-mediated inflammation.

  PMID 41644740 · PMC12988155 · EMBO molecular medicine · 2026 · 8 claims · 7 setups

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  Elevated serum D-Kyn levels correlate with stable graft function, while lower D-Kyn is associated with acute rejection

  serum kidney allogeneic ion scrna-seq pseudotime

• Cell-State-Specific Drug Responses are Associated With Differences in Signaling Network Wiring.

  PMID 41707849 · PMC13014938 · Molecular & cellular proteomics : MCP · 2026 · 8 claims · 4 setups

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  Drug treatment effects propagate from the EGF-signaling pathway to other connected parts of the cellular signaling network, indicating altered signaling flow.

  epidermal single-cell scrna-seq immuno-staining

• Integrative bulk and single-cell transcriptomics link EZH2 to immunosuppressive programs and tumor-Treg crosstalk in castration-resistant prostate cancer.

  PMID 41710887 · PMC12909565 · Frontiers in immunology · 2026 · 8 claims · 8 setups

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  Higher EZH2 expression is associated with adverse clinical outcomes in bulk PCa/CRPC cohorts

  tcga-prad su2c gse264573 gse137829 bulk scrna-seq ligand-receptor

• Tumor cell villages define the co-dependency of tumor and microenvironment in liver cancer.

  PMID 41723121 · PMC12932787 · Nature communications · 2026 · 8 claims · 8 setups

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  Different tumor cell transcriptomic states organize into distinct spatial clusters, or 'villages', each supported by a unique surrounding microenvironment

  liver malignant non-malignant tumor single-cell immunofluorescence non-negative