Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Targeted and personalized immunotherapy in lung adenocarcinoma: single-cell RNA sequencing of MAFF+ tumor cells and the therapeutic potential of FOS.

  PMID 40936936 · PMC12420628 · Frontiers in immunology · 2025 · 7 claims · 8 setups

  Has reproduction · 71

  A highly stem-like C0 MAFF+ tumor cell subtype dominates invasive LUAD, producing chemokines and activating lipid metabolism

  luad tumor a549 single-cell infercnv pseudotime

• spliceJAC: transition genes and state-specific gene regulation from single-cell transcriptome data.

  PMID 36321549 · PMC9627675 · Molecular systems biology · 2022 · 8 claims · 8 setups

  Has reproduction · 53

  spliceJAC uses unspliced and spliced mRNA count matrices to construct cell state-specific gene-gene regulatory interaction (Jacobian) matrices from scRNA-seq data

  bistable three-gene emt circuits simulation mixed-state grn

• EMTscore infers divergent EMT pathways from omics data and enables rapid screening for EMT-associated gene sets.

  PMID 42097304 · PMC13186194 · Bioinformatics (Oxford, England) · 2026 · 8 claims · 4 setups

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  EMTscore is an R package providing efficient, unbiased scoring of multiple EMT pathways from single-cell or bulk omics data

  small a549 trunk bulk scrna-seq

• Multiomic and functional validation of ACSL3, a regulator of fatty acid metabolism, as a lymph node metastasis-associated gene in lung adenocarcinoma.

  PMID 41998631 · PMC13261843 · Respiratory research · 2026 · 8 claims · 8 setups

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  A five-gene FAM-related risk signature (ACSL3, MCAT, NDUFAB1, OLAH, ACSL4)-derived FScore stratifies LUAD prognosis across multiple independent cohorts

  tcga-luad luad a549 lymphatic bulk scrna-seq spatial

• SiCmiR Atlas: Single-Cell miRNA Landscape Reveals Hub-miRNA and Network Signatures in Human Cancers.

  PMID 41691474 · PMC13042402 · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026 · 8 claims · 8 setups

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  SiCmiR, a two-layer neural network, predicts mature miRNA expression profiles from only 977 LINCS L1000 landmark genes

  tcga k562 pancreatic acth-secreting paired bulk scrna-seq-based

• Targeting KIFC1 to disrupt centrosome clustering and trigger anaphase catastrophe in small-cell lung cancer.

  PMID 41948931 · PMC13134724 · JCI insight · 2026 · 8 claims · 8 setups

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  KIFC1 is overexpressed in SCLC compared with normal tissues and other cancer types

  sclc h146 clinical cancer immunofluorescence viability flow

• Multi-Omics reveals SPP1 + malignant and CXCR4(+) TAM crosstalk predicts immunotherapy response in lung adenocarcinoma.

  PMID 42045760 · PMC13187092 · Discover oncology · 2026 · 8 claims · 8 setups

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  SPP1+ malignant and CXCR4+ TAM crosstalk drives CD8 T cell exhaustion and induces poor immunotherapy response

  luad tcga-luad epithelial a549 single-cell spatial bulk