Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Cross-species single-cell transcriptomic analyses reveal evolutionary conservation and diversification of ovarian tissues.

  PMID 41975518 · PMC13077819 · Journal of animal science and biotechnology · 2026 · 8 claims · 9 setups

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  Generated a multi-species ovarian atlas of 186,748 cells across nine vertebrate species, identifying nine major ovarian cell types

  chinese chicken ovary goat scrna-seq snrna-seq

• Souporcell3: robust demultiplexing for high-donor single-cell RNA-seq datasets.

  PMID 41808435 · PMC13012599 · Bioinformatics (Oxford, England) · 2026 · 8 claims · 3 setups

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  Souporcell3 can robustly demultiplex pooled scRNA-seq data from up to 64 donors

  pooled scrna-seq doublet genotype-based umap-based

• High-fidelity bidirectional translation between single-cell transcriptomes and DNA methylomes with scBOND.

  PMID 41887797 · PMC13138010 · Genome research · 2026 · 7 claims · 6 setups

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  scBOND is a bidirectional dual-channel VAE framework for cross-modality translation between scRNA-seq and scDNAm that outperforms existing baseline methods (scCross, MAPLE) in both translation directions

  mouseembryo humanbraina paired umap differential

• Integrating single-cell and single-nucleus datasets improves bulk RNA-seq deconvolution.

  PMID 41895263 · PMC13106970 · Cell reports methods · 2026 · 8 claims · 5 setups

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  scRNA-seq references yield significantly higher Pearson correlation and lower RMSE than snRNA-seq references for deconvolution across all four tissue datasets

  adipose same fat-cell real pseudobulk single-cell synthetic

• Interpretable trajectory inference with single-cell linear adaptive negative-binomial expression (scLANE) testing.

  PMID 41533563 · PMC12802912 · Nucleic acids research · 2026 · 8 claims · 3 setups

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  scLANE models gene expression as a piecewise negative-binomial GLM using truncated power basis (hinge) functions with adaptively chosen knots, yielding directly interpretable multiplicative effect sizes for trajectory differential expression

  zebrafish simulated diverse trajectory simulation

• To Explore the Key Subgroup and Their Immune Microenvironment During the Formation of Coronary Plaque With scRNA-seq.

  PMID 40454289 · PMC12126265 · Cardiology research and practice · 2025 · 6 claims · 8 setups

  Has reproduction · 33

  C1 RACK1+ NK cells are a crucial subgroup for understanding coronary plaque formation, exhibiting the highest cell stemness/differentiation potential and positioned at the start of the pseudotime trajectory

  coronary scrna-seq five type single-cell doublet copy

• CanSig Benchmarks Methods for Reproducible Cancer Cell State Discovery from Single-Cell Transcriptomic Data.

  PMID 41231245 · PMC13053056 · Cancer research · 2026 · 7 claims · 7 setups

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  CanSig is a comprehensive benchmarking tool for evaluating computational methods that identify shared transcriptional signatures in cancer from scRNA-seq data

  neftel kim scrna-seq same scrna-seq ground-truth robustness

• Identification and comparison of orthologous cell types from primate embryoid bodies shows limits of marker gene transferability.

  PMID 41949281 · PMC13061419 · eLife · 2026 · 7 claims · 6 setups

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  Human marker genes are less effective in macaques and vice versa, showing limited transferability of markers across species.

  ipsc-derived day integrated ipscs scrna-seq flow immunofluorescence

• Transcriptomic and phenotypic convergence of neurodevelopmental disorder risk genes in vitro and in vivo.

  PMID 42032432 · PMC13156037 · Nature neuroscience · 2026 · 6 claims · 6 setups

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  Transcriptomic convergence following NDD gene knockout is highly cell-type-specific and strongest in mature glutamatergic neurons (iGLUTs)

  hipsc-derived gwas computational zebrafish single-cell immunofluorescence magma

• Tumor reactivity assessment using clonal expression reveals tumor reactive CD8(+) T cell heterogeneity across solid tumors.

  PMID 42079667 · PMC13128579 · Frontiers in immunology · 2026 · 8 claims · 5 setups

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  TRACE, a clonotype-level CD8+ TRT classifier trained on an aggregated multi-study dataset, achieves robust holdout performance (mean MCC 0.84, F1 0.85)

  cd8+ expanded aggregated combined scrna-seq co-culture gene

• VISTA uncovers missing gene expression and spatial-induced information for spatial transcriptomic data analysis.

  PMID 41507434 · PMC12891734 · Communications biology · 2026 · 8 claims · 6 setups

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  VISTA predicts unmeasured gene expression in subcellular spatial transcriptomic data by integrating scRNA-seq and SST through variational inference and geometric deep learning with built-in uncertainty quantification

  brain breast embryo muscle imaging-based sequencing spot-based

• Genome-wide association analyses highlight the role of the intestinal molecular environment in human gut microbiota variation.

  PMID 41688638 · PMC12987725 · Nature genetics · 2026 · 8 claims · 8 setups

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  Variants in the OR51E1–OR51E2 locus, encoding microbiome-derived fatty acid chemosensors expressed in enteroendocrine cells, are associated with gut microbial richness

  adults subset intestinal enteroendocrine genome-wide sanger single-cell

• The proteomic landscape and temporal dynamics of human and mouse gastruloid development.

  PMID 42032312 · PMC13179132 · Nature cell biology · 2026 · 8 claims · 8 setups

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  Generated a quantitative proteomic, phosphoproteomic, and matched transcriptomic resource across four stages of human and mouse gastruloid development

  escs gastruloids sox2-mcitrine quantitative phosphoproteomics bulk

• Robust transcriptomic hallmarks targeting intratumor heterogeneity in intrahepatic cholangiocarcinoma.

  PMID 41916296 · PMC13130669 · Cell reports. Medicine · 2026 · 8 claims · 8 setups

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  Immune and stromal heterogeneity, rather than genetic variation, are primary drivers of gene expression ITH in iCCA

  multi-region icca four lihv bulk hallmark single-cell