Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Human neuronal differentiation under Aβ exposure: a single-cell transcriptomic and epigenomic dataset.

  PMID 41807428 · PMC13103403 · Scientific data · 2026 · 8 claims · 4 setups

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  A paired scRNA-seq and scATAC-seq dataset was generated from NPCs differentiated over Days 0, 7, 13, and 20 under baseline and Aβ 1-42 exposure conditions

  hipsc-derived hippocampal scrna-seq scatac-seq flow

• Single-Cell Transcriptome Profiling Reveals Multicellular Ecosystem of Nucleus Pulposus during Degeneration Progression.

  PMID 34825784 · PMC8787427 · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022 · 8 claims · 6 setups

  Has reproduction · 59

  Human NP contains six transcriptionally distinct NPC subpopulations: HT-CLNPs, effector NPCs, homeostatic NPCs, regulatory NPCs, fibroNPCs, and adhesion NPCs

  npcs scrna-seq-derived ht-clnp-i g-mdscs single-cell rt-qpcr immunohistochemistry

• l-2-Hydroxyglutarate impairs neuronal differentiation through epigenetic activation of MYC expression.

  PMID 41842973 · PMC13132370 · The Journal of clinical investigation · 2026 · 8 claims · 8 setups

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  L2HGDH deficiency causes L-2HG (not D-2HG) accumulation in patient plasma, fibroblasts, iPSCs, and NPCs

  plasma patient-derived unedited day-14 metabolomics crispr proliferation

• Stage-specific epigenetic priming amplifies gene activation during lineage commitment.

  PMID 41894493 · PMC13025117 · Science advances · 2026 · 8 claims · 8 setups

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  Full-body Msl1 knockout causes embryonic lethality by E10.5, with morphological/developmental delay detectable already at E8.5

  embryos e9.5 mesc-derived bright-field western 10x