Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Distinct senotypes in p16- and p21-positive cells across human and mouse aging tissues.

  PMID 41162753 · PMC12669595 · The EMBO journal · 2025 · 7 claims · 8 setups

  Has reproduction · 50

  p16+ and p21+ senescent cells represent largely distinct, non-overlapping populations across murine and human aging tissues

  hippocampus brain skeletal bone scrna-seq cytof velocity

• Spatiotemporal Transcriptomics Characterizes Immune Microenvironment During Mouse Liver Aging.

  PMID 42010880 · PMC13096584 · Aging cell · 2026 · 8 claims · 8 setups

  Full-text index only

  T cells are the immune cell population with the most pronounced transcriptomic alterations during liver aging

  liver nash cirrhotic hcc scrna-seq snrna-seq stereo-seq

• Paneth cell SIRT1 deficiency increases intestinal stress resistance by modulating the gut microbiota.

  PMID 41826553 · PMC13076647 · EMBO reports · 2026 · 8 claims · 8 setups

  Full-text index only

  Generated a novel Paneth-cell-specific SIRT1 knockout mouse model (SIRT1 PKO, Sirt1 f/f;Defa6-Cre+)

  small immune facs-sorted ileum single-cell facs qpcr

• Aging-dependent microglial heterogeneity worsens outcomes in models of traumatic brain injury.

  PMID 41926211 · PMC13262727 · The Journal of clinical investigation · 2026 · 8 claims · 8 setups

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  Aged TBI brains predominantly harbor proinflammatory NLRP3+ microglia, whereas young TBI brains harbor neuroprotective Lysozyme+ microglia

  injured sorted facs-purified cas9-gfp scrna-seq atac-seq untargeted

• Spatial-reprogramming derived GPNMB(+) macrophages interact with COL6A3(+) fibroblasts to enhance vascular fibrosis in glioblastoma.

  PMID 41174767 · PMC12577258 · Genome medicine · 2025 · 8 claims · 8 setups

  Has reproduction · 64

  COL6A3+ TAFs are a distinct matrix-fibroblast subset significantly enriched in non-responders to neoadjuvant antiangiogenic+ICB combination therapy

  gbm ffpe col6a3+ thp-1 scrna-seq spatial multiplex

• Single-Cell Profiling Across Immune Tissues and Organs Reveals Immunosenescence Signatures in Male Rhesus Monkeys.

  PMID 41556329 · PMC13042567 · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026 · 7 claims · 8 setups

  Full-text index only

  GZMB is markedly upregulated across multiple cell types in aged rhesus monkeys and serves as a candidate biomarker of immunosenescence

  bone cd8+ mesenteric sections single-cell gene pseudotime

• Development of a pediatric immune cell atlas and characterization of CD4+ T cells in food allergy.

  PMID 42025535 · PMC13105851 · Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026 · 8 claims · 8 setups

  Full-text index only

  A pediatric single-cell PBMC reference atlas was developed from 57 healthy children across 8 public scRNA-seq studies.

  pbmcs cd3+ cd4+ memory scrna-seq pseudobulk bulk

• Single-cell dissection of regulated cell death dynamics in ovarian aging.

  PMID 41689119 · PMC13005338 · Journal of ovarian research · 2026 · 8 claims · 8 setups

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  The RCD landscape of ovarian aging had not previously been characterized at single-cell resolution

  ovary serum scrna-seq bulk single-nucleus

• Single-cell analysis of testicular bacterial microbiome changes during aging and effect on reproductive capacity in mice.

  PMID 41438041 · PMC12719757 · iScience · 2025 · 8 claims · 8 setups

  Has reproduction · 78

  INVADE-seq (single-cell RNA-seq combined with 16S rRNA targeting) detects a sparse but widespread bacterial presence across diverse testicular cell types

  testis young testicular invade-seq histology sperm

• ICE: robust detection of cellular senescence from weak single-cell signatures using imputation-based marker refinement.

  PMID 41668152 · PMC12990438 · Genome biology · 2026 · 8 claims · 7 setups

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  Senescence-associated marker genes show weak, non-specific expression across human tissues and cell types compared to canonical tissue/cell-type markers

  tissues pancreas pancreatic brain bulk scrna-seq train

• Identification of a new population of Tnn(+) progenitors to form tendon enthesis fibrocartilage.

  PMID 42009636 · PMC13096267 · Bone research · 2026 · 8 claims · 8 setups

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  A novel Tnn+ progenitor cell population resides in the tendon enthesis and serves as a cellular origin of fibrocartilage lineages

  tendon developing spatial single-cell visium single-cell stamp

• PURE-seq integrates FACS and PIP-seq for single-cell genomics of ultra-rare cells.

  PMID 41565684 · PMC12881479 · Nature communications · 2026 · 8 claims · 8 setups

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  PURE-seq integrates FACS sorting directly into PIP-seq barcoding reaction tubes, minimizing manual handling and cell loss for rare-cell single-cell sequencing.

  hek293t pbmcs melanoma bone single-cell infercnv gene