Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Development of double-positive thymocytes at single-cell resolution.

  PMID 33771202 · PMC8004397 · Genome medicine · 2021 · 7 claims · 8 setups

  Has reproduction · 86

  DP thymocytes can be classified into blast, rearrangement, and selection subtypes, distinguishable by surface markers CD2 and Ly6d

  thymocytes sorted thymocyte scrna-seq flow immunofluorescence

• PBRM1 Deficiency Reshapes an Immune Suppressive Microenvironment Through Epigenetic Tuning of PBRM1-KDM5C-IL6 Axis in ccRCC.

  PMID 41514194 · PMC13042695 · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026 · 8 claims · 8 setups

  Full-text index only

  PBRM1 deficiency increases infiltration of immunosuppressive M2 tumor-associated macrophages (TAMs) and creates an immune-excluded tumor microenvironment

  vhl kidney pbrm1 immunodeficient scrna-seq multiplex crispr-cas9

• Tumour-intrinsic features shape T cell differentiation through precursor to symptomatic multiple myeloma.

  PMID 41644568 · PMC12982522 · Nature communications · 2026 · 8 claims · 6 setups

  Full-text index only

  MM is not characterized by T cell exhaustion but by antigen-driven terminal memory differentiation, unlike solid cancers

  bone cd69+ cd8+ smm single-cell cite-seq gene

• Clonal CD8(+) T cells populate the leptomeninges and coordinate with immune cells in human degenerative brain diseases.

  PMID 41593242 · PMC12864034 · Nature immunology · 2026 · 8 claims · 6 setups

  Full-text index only

  The human leptomeninges harbor substantial numbers of clonally expanded, tissue-resident memory CD8 T cells (ZNF683-high, CXCR6+, PD-1+)

  postmortem leptomeninges scrna-seq-derived leptomeningeal single-cell flow imaging

• Humoral IgG1 responses to tumor antigens underpin clinical outcomes in immune checkpoint blockade.

  PMID 41593194 · PMC13004670 · Nature medicine · 2026 · 8 claims · 5 setups

  Full-text index only

  PD-1 blockade induces tumor-specific IgG1+ plasma cell responses that complement cellular immunity and contribute to clinical benefit

  tumor paired single-cell bulk multiplex

• Vγ1 γδ T cells steer airway macrophages toward a profibrotic response in an autochthonous lung cancer mouse model.

  PMID 41779856 · PMC12959402 · Science advances · 2026 · 7 claims · 6 setups

  Full-text index only

  Lung tumors drive expansion of both CD27+ and CD27- pulmonary γδ T cells, which acquire distinct spatial and phenotypic changes in the tumor microenvironment

  spc-cre+ microdissected sorted merged flow confocal single-cell

• Distinct phenotypes and repertoires of bronchoalveolar and airway mucosal T cells in health and allergic asthma.

  PMID 41519381 · PMC12983186 · Mucosal immunology · 2026 · 8 claims · 6 setups

  Full-text index only

  BAL and endobronchial brush sampling capture phenotypically and clonally distinct T cell populations

  sorted paired bal subjects single-cell fluorescence-activated methacholine