Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Aurkb deficiency disrupts microglial development, homeostasis and hinders remyelination following cuprizone-induced demyelination.

  PMID 41704758 · PMC12907124 · iScience · 2026 · 8 claims · 8 setups

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  Aurkb is upregulated in a subset of fetal/neonatal microglia and in microglia following CPZ-induced demyelination and in MS patient microglia

  microglia brain neonatal corpus scrna-seq western immunofluorescence

• Opioid-induced transcriptional reprogramming of cerebrospinal fluid immune cells is associated with neuroinflammatory signaling in antiretroviral treated SIV-infected rhesus macaques.

  PMID 42010620 · PMC13227897 · Journal of neuroinflammation · 2026 · 8 claims · 5 setups

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  Morphine-dependent macaques show increased CD4+ TCM and Treg cell proportions and decreased CD8+ TEM cell proportions in CSF at the pre-infection timepoint compared to saline controls

  csf scrna-seq necropsy single-cell flow cell-cell

• Single cell transcriptional evolution of myeloid leukemia of Down syndrome.

  PMID 42026063 · PMC13106683 · Nature communications · 2026 · 8 claims · 5 setups

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  Transcriptional changes induced by TAM-defining GATA1 mutations are retained in and account for most of the ML-DS transcriptome, persisting even in progressive disease that has undergone further genetic evolution.

  foetal blasts leukaemias normal single-cell bulk whole-genome

• Integrating transcriptomic datasets across neurological disease identifies unique myeloid subpopulations driving disease-specific signatures.

  PMID 36527260 · PMC10952672 · Glia · 2023 · 6 claims · 3 setups

  Has reproduction · 26

  The bulk microglial and monocyte transcriptomic program is highly contingent on the disease environment, challenging the notion of a universal microglial disease signature

  acutely microglia c57bl meta-analysis integration spectral

• Integrative CSF profiling identifies disease-specific immune responses in leptomeningeal disease.

  PMID 41794040 · PMC13006398 · Cell reports. Medicine · 2026 · 8 claims · 8 setups

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  CSF exhibits distinct, disease-specific immune landscapes across CNSL, BrMs, and GB-associated LMD

  csf peripheral brain cell-free single-cell deep spatial