Experiments
Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).
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Antigen specificity of clonally enriched CD8(+) T cells in multiple sclerosis.
PMID 41644766 · PMC12956596 · Nature immunology · 2026 · 8 claims · 7 setups
A subset of 23 highly expanded, CSF-enriched CD8+ T cell clonotypes exists predominantly in the CSF of the MS/CIS cohort.
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Clonal CD8(+) T cells populate the leptomeninges and coordinate with immune cells in human degenerative brain diseases.
PMID 41593242 · PMC12864034 · Nature immunology · 2026 · 8 claims · 6 setups
The human leptomeninges harbor substantial numbers of clonally expanded, tissue-resident memory CD8 T cells (ZNF683-high, CXCR6+, PD-1+)
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Unique phenotypic and T cell receptor characteristics of CD8(+) T cells accumulated in the brains of Alzheimer's disease mice.
PMID 41794902 · PMC13087195 · Scientific reports · 2026 · 8 claims · 5 setups
Brain CD8+ T cells segregate into two major, mutually exclusive Trm populations: a CXCR6-related immunosuppressive cluster (cd8_c0) present in both aged non-Tg and 5xFAD_WT mice, and an AD-associated stem-like cluster (cd8_c1) present only in 5xFAD mice.
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Humoral IgG1 responses to tumor antigens underpin clinical outcomes in immune checkpoint blockade.
PMID 41593194 · PMC13004670 · Nature medicine · 2026 · 8 claims · 5 setups
PD-1 blockade induces tumor-specific IgG1+ plasma cell responses that complement cellular immunity and contribute to clinical benefit