Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• comBO: A combined human bone and lympho-myeloid bone marrow organoid for preclinical modeling of hematopoietic disorders.

  PMID 41734765 · PMC7618947 · Cell stem cell · 2026 · 8 claims · 8 setups

  Has reproduction · 65

  comBO is a single iPSC-derived organoid differentiation that generates osteolineage, vascular, lymphoid, and myeloid compartments together

  hipsc-derived combo combo-derived healthy-donor flow single-cell confocal

• Synergistic targeting of eIF4A-mediated translation initiation and apoptosis in acute myeloid leukemia.

  PMID 41815287 · PMC12971725 · Blood neoplasia · 2026 · 8 claims · 8 setups

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  EIF4A1 is highly expressed in AML stem- and progenitor-like cells relative to healthy hematopoietic stem/progenitor cells

  healthy aml molm-13 patient-derived single-cell bulk cell-titerglo

• Protocol for generating and characterizing Matrigel-free prostate cancer patient-derived organoids.

  PMID 41955100 · PMC13091043 · STAR protocols · 2026 · 7 claims · 7 setups

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  A Matrigel-free culture protocol improves both take-rate and proportion of tumor cells within PCa PDO cultures compared to traditional Matrigel-based approaches

  pca turp ffpe organoid serial frozen

• Therapeutic synergies that overcome carboplatin resistance in triple-negative breast cancer.

  PMID 41630032 · PMC13037280 · Journal of experimental & clinical cancer research : CR · 2026 · 8 claims · 8 setups

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  Four isogenic carboplatin-resistant (CR) PDX pairs (WHIM30, BCM-2147, BCM-3887, BCM-7482) were generated via serial in vivo carboplatin exposure to model acquired resistance in TNBC

  isogenic pdx ffpe carboplatin-resistant bulk single-cell nuclear

• Neoadjuvant sintilimab plus chemotherapy in EGFR-mutant NSCLC: Phase 2 trial interim results (NEOTIDE/CTONG2104).

  PMID 38897205 · PMC11293361 · Cell reports. Medicine · 2024 · 8 claims · 8 setups

  Has reproduction · 72

  Neoadjuvant sintilimab plus carboplatin/nab-paclitaxel is clinically feasible and tolerable in resectable EGFR-mutant NSCLC, with all 18 patients completing treatment and undergoing radical surgery.

  pre resected tumor serial whole-exome bulk single-cell

• Tbx5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development.

  PMID 34643182 · PMC8555986 · eLife · 2021 · 7 claims · 8 setups

  Has reproduction · 84

  Tbx5 directly maintains Aldh1a2 expression in the foregut lateral plate mesoderm via an evolutionarily conserved intronic enhancer

  e9.5 xenopus bulk rt-qpcr whole-mount

• Blood feeding triggers the terminal differentiation of precursor cells in tick salivary glands.

  PMID 41880507 · PMC13015885 · Science advances · 2026 · 8 claims · 8 setups

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  Unfed I. scapularis salivary glands contain a conserved population of undifferentiated precursor cells.

  scapularis scrna-seq bulk immunofluorescence single-cell

• Rapid detection of SMARCB1 sequence variation using high resolution melting.

  PMID 20003390 · PMC2801682 · BMC cancer · 2009 · 8 claims · 6 setups

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  HRM screening of SMARCB1 amplicons has a zero false negative rate compared to direct sequencing

  genomic same tumor rhabdoid high direct hrm

• Confounding factors in assessing the enriched expression of somatic mutant alleles in bulk tumor samples.

  PMID 41781335 · PMC13138019 · Genome research · 2026 · 8 claims · 8 setups

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  Mutation-based ASE detection in bulk tumor samples can be confounded by gene expression differences between tumor and normal cells, producing apparent enrichment of the mutant allele in RNA without true ASE.

  tcga cutaneous serially whole-exome bulk novo

• Inherited resilience to clonal hematopoiesis by modifying stem cell RNA regulation.

  PMID 41477881 · PMC12850507 · Science (New York, N.Y.) · 2026 · 8 claims · 8 setups

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  A haplotype at the 17q22 locus, tagged by the noncoding variant rs17834140-T, is a causal protective variant against CHIP and myeloid malignancies

  population hspcs cd34+cd45ra-cd90+ heterozygous gwas atac-seq crispr