Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 289

Assay: serum ✕ Clear

A new form of diabetes caused by INS mutations defined by zygosity, stem cell and population data.

PMID 41484206 · PMC12905373 · EMBO molecular medicine · 2026 · 6 claims · 7 setups

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INS R6C is a recessive loss-of-function mutation causing diabetes only in homozygous individuals, not a dominant mutation as previously classified.

blood serum large-scale computational targeted autoantibody population
25th Annual San Antonio Breast Cancer Symposium, San Antonio, Texas, USA, 10-14 December 2002 Update on preclinical and translational research.

PMID 12631391 · PMC154153 · Breast cancer research : BCR · 2003 · 8 claims · 8 setups

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Growth factor signalling (EGF/HER-2/MAPK, AKT) phosphorylates the oestrogen receptor and drives development of endocrine-resistant breast cancer

xenograft serum frozen tumour xenograft mass cdna
The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue.

PMID 28346411 · PMC5699924 · Nature medicine · 2017 · 8 claims · 8 setups

Has reproduction · 78

12,13-diHOME is a cold-induced lipokine that stimulates BAT activity

plasma bat serum mice lc-ms correlation 18f-fdg
An attenuated phenotype of Costello syndrome in three unrelated individuals with a HRAS c.179G>A (p.Gly60Asp) mutation correlates with uncommon functional consequences.

PMID 25914166 · PMC4830354 · American journal of medical genetics. Part A · 2015 · 7 claims · 8 setups

Has reproduction

HRAS c.179G>A (p.Gly60Asp) causes an attenuated Costello syndrome phenotype without severe failure-to-thrive, intellectual disability, or cancer predisposition

cos-7 transiently patients parental ras co-immunoprecipitation immunoblotting
An atlas of the human liver diurnal transcriptome and its perturbation by hepatitis C virus infection.

PMID 39209804 · PMC11362569 · Nature communications · 2024 · 7 claims · 7 setups

Has reproduction · 50

Human hepatocytes engrafted in liver chimeric mice display a large rhythmic transcriptome of ~1700 protein-coding orthologous genes, including transcription factors, chromatin modifiers, and metabolic enzymes.

liver hcv-infected serum bulk chip-seq serum
Cellular responses to ErbB-2 overexpression in human mammary luminal epithelial cells: comparison of mRNA and protein expression.

PMID 14710226 · PMC2395336 · British journal of cancer · 2004 · 7 claims · 5 setups

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There is a surprisingly high correlation between transcription and translation for the subset of genes studied by parallel microarray and proteomics analysis

hb4a serum-starved cdna 2d-difference immunoblotting
Segregation of a M404V mutation of the p62/sequestosome 1 (p62/SQSTM1) gene with polyostotic Paget's disease of bone in an Italian family.

PMID 16277682 · PMC1297578 · Arthritis research & therapy · 2005 · 6 claims · 4 setups

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The M404V mutation in p62/SQSTM1 exon 8 segregates with the polyostotic form of PDB in the F01 Italian family

genomic serum affected pcr pcr biochemical clinical
Science star over Asia.

PMID 16149850 · PMC1201306 · PLoS biology · 2005 · 8 claims · 7 setups

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Ariff Bongso and associates at Singapore's National University Hospital were the first to derive human embryonic stem cells, from a five-day-old discarded human embryo in 1994, and showed the cells were pluripotent with therapeutic transplant potential.

blastocyst embryonic fugu rice embryo culture whole-genome
A Korean family of hypokalemic periodic paralysis with mutation in a voltage-gated calcium channel (R1239G).

PMID 15716625 · PMC2808567 · Journal of Korean medical science · 2005 · 8 claims · 6 setups

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A 13-year-old boy and five affected relatives across three generations with hypokalemic periodic paralysis carry the R1239G mutation in CACNA1S

proband cousins mutation serum electrocardiography
Independent component analysis reveals new and biologically significant structures in micro array data.

PMID 16762055 · PMC1557674 · BMC bioinformatics · 2006 · 7 claims · 8 setups

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ICA applied to three microarray datasets reveals many biologically significant components, including low-ranking ones not obvious by rank alone

acute serum-stimulated head aml microarray clust term
Genetic variants of adiponectin receptor 2 are associated with increased adiponectin levels and decreased triglyceride/VLDL levels in patients with metabolic syndrome.

PMID 16700915 · PMC1482678 · Cardiovascular diabetology · 2006 · 8 claims · 6 setups

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A haplotype of three AdipoR2 variants (+795G/A, +870C/A, +963C/T) in perfect linkage disequilibrium is associated with higher plasma adiponectin levels and lower fasting triglyceride, VLDL-triglyceride, and VLDL-cholesterol levels

peripheral plasma subjects adipor1 sequencing plasma preparative
Prevalence of A2143G mutation of H. pylori-23S rRNA in Chinese subjects with and without clarithromycin use history.

PMID 18507832 · PMC2427034 · BMC microbiology · 2008 · 7 claims · 6 setups

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A2143G point mutation of the H. pylori 23S rRNA gene causes clarithromycin resistance

fasting subjects serum pylori pcr 13c-urea elisa
Proteomic approaches to cancer biomarkers.

PMID 19931265 · PMC2873613 · Gastroenterology · 2010 · 8 claims · 8 setups

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Combining abundant-protein depletion, offline fractionation, and subproteome (e.g., glycoproteome) enrichment with 2D LC-MS/MS increases the dynamic range and depth of blood proteome analysis for biomarker discovery.

plasma serum capan-2 apcδ580 lectin silac elisa
Acetyl-coenzyme A carboxylase alpha gene variations may be associated with the direct effects of some antipsychotics on triglyceride levels.

PMID 19846279 · PMC2784140 · Schizophrenia research · 2009 · 8 claims · 5 setups

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ACACA SNP rs2229416 was previously found significantly associated with hypertriglyceridemia in patients on H1-blocking antipsychotics

psychiatric same antipsychotic-treated snp logistic serum
Building exposure biology centers to put the E into "G x E" interaction studies.

PMID 19672377 · PMC2721881 · Environmental health perspectives · 2009 · 8 claims · 4 setups

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Nongenetic factors account for high attributable risk (often 80-90%) across many chronic diseases, underscoring the importance of environmental exposure.

mars water archived dried capillary surface adductomics
Global proteome analysis of Leptospira interrogans.

PMID 19663501 · PMC2757032 · Journal of proteome research · 2009 · 8 claims · 5 setups

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563 proteins were identified in L. interrogans via combined iTRAQ and 2DGE proteomic analysis

leptospira serum liver itraq two-dimensional immunoblot
Amplicon sequencing with Oxford nanopore technologies as a diagnostic alternative for small ruminant lentiviruses in sheep.

PMID 41582101 · PMC12905341 · Scientific reports · 2026 · 7 claims · 8 setups

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Nanopore amplicon sequencing of blood DNA reduces false negatives compared to ELISA (42%) and qPCR (77%)

blood sheep blood-derived pbmc-enriched qpcr elisa nanopore
PFOS and PFOA exposure induces liver injury and sex-dependent immune effects in C57BL/6 mice.

PMID 41641100 · PMC12865548 · iScience · 2026 · 7 claims · 7 setups

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PFOA and PFOS exposure induces hepatotoxicity, including hepatomegaly and elevated serum liver injury biomarkers (ALP, ALT), across sexes and durations

plasma liver serum thymus lc-ms organ serum
Developments in CORG: a gene-centric comparative genomics resource.

PMID 17135197 · PMC1751536 · Nucleic acids research · 2007 · 7 claims · 4 setups

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CORG provides pairwise and multiple sequence alignments of upstream promoter regions and whole gene loci across 10 vertebrate species.

upstream gene overlapping c-fos pairwise sequence comparative
Single-cell transcriptomics and chromatin accessibility profiling elucidate the kidney-protective mechanism of mineralocorticoid receptor antagonists.

PMID 37906287 · PMC10760974 · The Journal of clinical investigation · 2024 · 8 claims · 8 setups

Has reproduction · 95

Mineralocorticoid effects are established through open chromatin and target gene expression primarily in principal and connecting tubule cells, and to a lesser extent in distal convoluted tubule cells

kidney live blood snrna-seq snatac-seq bulk

Experiments

A new form of diabetes caused by INS mutations defined by zygosity, stem cell and population data.

25th Annual San Antonio Breast Cancer Symposium, San Antonio, Texas, USA, 10-14 December 2002 Update on preclinical and translational research.

The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue.

An attenuated phenotype of Costello syndrome in three unrelated individuals with a HRAS c.179G>A (p.Gly60Asp) mutation correlates with uncommon functional consequences.

An atlas of the human liver diurnal transcriptome and its perturbation by hepatitis C virus infection.

Cellular responses to ErbB-2 overexpression in human mammary luminal epithelial cells: comparison of mRNA and protein expression.

Segregation of a M404V mutation of the p62/sequestosome 1 (p62/SQSTM1) gene with polyostotic Paget's disease of bone in an Italian family.

Science star over Asia.

A Korean family of hypokalemic periodic paralysis with mutation in a voltage-gated calcium channel (R1239G).

Independent component analysis reveals new and biologically significant structures in micro array data.

Genetic variants of adiponectin receptor 2 are associated with increased adiponectin levels and decreased triglyceride/VLDL levels in patients with metabolic syndrome.

Prevalence of A2143G mutation of H. pylori-23S rRNA in Chinese subjects with and without clarithromycin use history.

Proteomic approaches to cancer biomarkers.

Acetyl-coenzyme A carboxylase alpha gene variations may be associated with the direct effects of some antipsychotics on triglyceride levels.

Building exposure biology centers to put the E into "G x E" interaction studies.

Global proteome analysis of Leptospira interrogans.

Amplicon sequencing with Oxford nanopore technologies as a diagnostic alternative for small ruminant lentiviruses in sheep.

PFOS and PFOA exposure induces liver injury and sex-dependent immune effects in C57BL/6 mice.

Developments in CORG: a gene-centric comparative genomics resource.

Single-cell transcriptomics and chromatin accessibility profiling elucidate the kidney-protective mechanism of mineralocorticoid receptor antagonists.