Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 4

System / cell line: e.g ✕ Assay: silac ✕ Clear

Acetylation goes global: the emergence of acetylation biology.

PMID 19920250 · PMC2812806 · Science signaling · 2009 · 8 claims · 4 setups

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Whole-proteome acetylome mapping (via SILAC-coupled high-resolution MS) shows the acetylome approaches the size and complexity of the phosphoproteome, indicating acetylation is a widespread regulatory modification rather than a niche one.

proteome proteome-wide liver anti-acetyllysine silac-based silac-coupled
A new era for proteomics research?

PMID 19014405 · PMC2614486 · Genome biology · 2008 · 8 claims · 8 setups

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Refined mass spectrometry instrumentation and software now make whole-proteome coverage of model organisms in a single experiment conceivable

proteins lines kinases breast mass silac kinase-specific
Proteomic approaches to cancer biomarkers.

PMID 19931265 · PMC2873613 · Gastroenterology · 2010 · 8 claims · 8 setups

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Combining abundant-protein depletion, offline fractionation, and subproteome (e.g., glycoproteome) enrichment with 2D LC-MS/MS increases the dynamic range and depth of blood proteome analysis for biomarker discovery.

plasma serum capan-2 apcδ580 lectin silac elisa
Proteomics-based identification of novel factor inhibiting hypoxia-inducible factor (FIH) substrates indicates widespread asparaginyl hydroxylation of ankyrin repeat domain-containing proteins.

PMID 18936059 · PMC2649815 · Molecular & cellular proteomics : MCP · 2009 · 8 claims · 5 setups

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DMOG pretreatment acts as a pharmacological 'substrate trap' that stabilizes transient FIH-substrate interactions, enabling their identification by SILAC-based proteomics

hek293 u2os 293t 293t-expressed co-immunoprecipitation silac-based co-immunoprecipitation-immunoblotting

Experiments

Acetylation goes global: the emergence of acetylation biology.

A new era for proteomics research?

Proteomic approaches to cancer biomarkers.

Proteomics-based identification of novel factor inhibiting hypoxia-inducible factor (FIH) substrates indicates widespread asparaginyl hydroxylation of ankyrin repeat domain-containing proteins.