Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Paneth cell SIRT1 deficiency increases intestinal stress resistance by modulating the gut microbiota.

  PMID 41826553 · PMC13076647 · EMBO reports · 2026 · 8 claims · 8 setups

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  Generated a novel Paneth-cell-specific SIRT1 knockout mouse model (SIRT1 PKO, Sirt1 f/f;Defa6-Cre+)

  small immune facs-sorted ileum single-cell facs qpcr

• Impact of enteric neuronal loss on intestinal cell composition.

  PMID 42063560 · PMC13127327 · iScience · 2026 · 8 claims · 7 setups

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  ENS loss in ret mutant zebrafish alters the non-neuronal composition of the intestine, with increased immune cells and shifts in epithelial and ECM-producing populations

  intestine ens immune phox2bb single-cell scrna-seq whole-mount

• Enteroendocrine cell lineages that differentially control feeding and gut motility.

  PMID 36810133 · PMC10032656 · eLife · 2023 · 6 claims · 8 setups

  Has reproduction · 88

  Vil1-p2a-FlpO knock-in mice combined with lineage-specific Cre lines enable highly selective intersectional genetic access to major enteroendocrine cell lineages (serotonin/enterochromaffin, GLP1, CCK, somatostatin, GIP) in vivo

  neurod1-cre neurog3-cre intestinal vil1-p2a-flpo single-cell fluorescence-activated two-color

• A tumor-intrinsic WNT-inhibitory NOTUM program drives immune resistance in microsatellite stable colorectal cancer.

  PMID 42097145 · PMC13198260 · Cell reports. Medicine · 2026 · 8 claims · 7 setups

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  A distinct NOTUM/NKD1/APCDD1-high, WNT-inhibitory cancer cell population (WICC) emerges predominantly in advanced-stage MSS CRC

  crc patient-derived ibd mmr-proficient single-cell cell-cycle patient-level

• Charting spatial ligand-target activity using Renoir.

  PMID 42086556 · PMC13144314 · Nature communications · 2026 · 8 claims · 8 setups

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  Renoir computes a neighborhood activity score for curated ligand-target pairs at each spatial spot/cell by integrating cell type abundance, cell type-specific mRNA abundance, receptor expression, gene entropy, and mutual information between ligand and target genes.

  intestine triple-negative dorsolateral dlpfc semi-synthetic spatial single-cell

• Developing a comprehensive database and search tool for single-cell ATAC-seq data.

  PMID 41545440 · PMC12816011 · Scientific reports · 2026 · 5 claims · 6 setups

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  scATAC.Explorer is a curated database containing 39 publicly available scATAC-seq datasets in a consistent format

  hematopoietic drosophila cancer scatac-seq sci-atac-seq sci-car

• Vertebrate-wide transcriptomic screening identifies immune cell-specific expression of the conserved OR-κ gene.

  PMID 41654976 · PMC13113109 · Zoological letters · 2026 · 8 claims · 8 setups

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  The majority (95-97%) of chemoreceptor genes are expressed in nasal/oral chemosensory organs across mouse, Xenopus, Polypterus, and zebrafish

  mus zebrafish xenopus polypterus bulk single-cell molecular

• Secreted phospholipase PLA2G5 acts as a hemolytic factor in sepsis.

  PMID 42065235 · PMC13132393 · The Journal of clinical investigation · 2026 · 8 claims · 8 setups

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  Pla2g5 gene expression is induced in the colon and small intestine during LPS-induced endotoxemia and CLP-induced sepsis in mice

  colon mice serum bone whole-mount rna-seq survival

• Spatial transcriptomics maps host-gut microbiome biogeography at high resolution.

  PMID 41792309 · PMC13171632 · Nature microbiology · 2026 · 7 claims · 6 setups

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  Enzymatic in situ polyadenylation increases bacterial RNA recovery in oligo(dT)-based spatial transcriptomics arrays by up to ~100-fold while preserving host gene capture

  apc-deficient heart ileum fresh-frozen spatial high-resolution bulk

• Candidate target genes for loss of heterozygosity on human chromosome 17q21.

  PMID 15187990 · PMC2409524 · British journal of cancer · 2004 · 8 claims · 5 setups

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  JUP (plakoglobin) is the only identified gene physically located between the D17S746 and D17S846 markers that define the smallest common region of LOH on chromosome 17q21

  genomic normal breast p1-phage nucleotide rt-pcr cold

• Loss of fungal sensing exacerbates liver injury in a murine model of MASLD.

  PMID 41805789 · PMC13135407 · JCI insight · 2026 · 8 claims · 8 setups

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  Patients with advanced liver fibrosis exhibit distinct gut mycobiota profiles, with the genus Penicillium notably reduced in severe fibrosis

  fecal wild-type gut card9 16s random diet-induced

• Splicing retention and enhancer divergence govern the evolutionary fate of ohnologues following whole-genome duplication in rainbow trout.

  PMID 41832354 · PMC13106644 · Scientific reports · 2026 · 7 claims · 8 setups

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  Most rainbow trout ohnologues are retained through conservation (71.4%) rather than neo/sub-functionalization or specialization

  rainbow swanson atlantic northern rna-seq chip-seq all-by-all

• The chromosomal genome sequence of the moon jellyfish, Aurelia sp. 4 Dawson et al. 2005 (Semaeostomeae: Ulmaridae) and its associated microbial metagenome sequences.

  PMID 42116832 · PMC13157608 · Wellcome open research · 2026 · 7 claims · 8 setups

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  Aurelia sp. 4 chromosomal genome assembly has a total length of 462.10 Mb with 99.99% of sequence scaffolded into 21 chromosomal pseudomolecules

  aurelia microbial pacbio hi-c rna-seq

• Telomere-to-telomere gapless genome assembly of Siniperca scherzeri.

  PMID 41927586 · PMC13216646 · Scientific data · 2026 · 8 claims · 8 setups

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  Integrated PacBio HiFi, ONT ultra-long reads, and Hi-C scaffolding to assemble a near-complete T2T genome of S. scherzeri

  genomic nuclear pooled assembled pacbio oxford illumina