Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Integrated transcriptome and single-cell sequencing analysis identify blood-pancreas shared lncRNA biomarkers in new-onset T2DM.

  PMID 41915667 · PMC13037964 · PloS one · 2026 · 8 claims · 6 setups

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  1,709 lncRNAs are differentially expressed in peripheral blood of new-onset T2DM patients vs controls

  peripheral pancreatic predicted bulk weighted single-cell

• NGSTroubleFinder: a tool for detection and quantification of contamination and kinship across human NGS data.

  PMID 41608734 · PMC12838523 · NAR genomics and bioinformatics · 2026 · 8 claims · 8 setups

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  NGSTroubleFinder detects cross-sample contamination, sample swaps, kinship, and sex mismatches from BAM/CRAM files without requiring additional variant-calling steps

  genomes 1000gp internal whole-genome whole-transcriptome wgs

• Association of polymorphisms in cyclooxygenase (COX)-2 with coronary and carotid calcium in the Diabetes Heart Study.

  PMID 18768181 · PMC2699582 · Atherosclerosis · 2009 · 8 claims · 6 setups

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  COX-2 promoter SNP rs689466 is associated with lower coronary calcified plaque (CorCP)

  whole-blood-derived subjects dhs unrelated snp coronary carotid

• The (CTG)n polymorphism in the NOTCH4 gene is not associated with schizophrenia in Japanese individuals.

  PMID 11407996 · PMC32311 · BMC psychiatry · 2001 · 6 claims · 4 setups

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  No significant differences in genotype or allele frequencies of the NOTCH4 (CTG)n repeat were found between schizophrenia patients and controls

  genomic pcr genotype pcr-based direct pcr

• Comprehensive cellular analysis with single-nucleus RNA-seq of archived PAXgene whole blood samples.

  PMID 41844163 · PMC13030975 · Cell reports methods · 2026 · 8 claims · 7 setups

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  Cell lysis (CL) nuclei isolation yields substantially more nuclei and less biased immune cell proportions than mechanical separation (MS)

  frozen paxgene cl-derived thawed single-nucleus confocal brightfield

• WBT-DC pipeline: a cross-cohort and cross-platform disease classification pipeline based on whole-blood transcriptomics.

  PMID 42116144 · PMC13173921 · Journal of translational medicine · 2026 · 8 claims · 8 setups

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  WBT-DC integrates rank-based GSVA feature extraction with an ensemble random forest framework using cross-validation and hyperparameter optimization to mitigate batch effects.

  blood circulating whole-blood bulk microarray single-cell

• Genomic and transcriptomic plasticity in treatment-naive ovarian cancer.

  PMID 24221193 · PMC3912411 · Genome research · 2014 · 8 claims · 8 setups

  Has reproduction · 30

  Treatment-naïve epithelial ovarian cancers show extensive intra-tumor heterogeneity of genomic rearrangements, with the most substantial differences occurring between omentum/peritoneum metastases and ovarian tumor sites.

  tumor each rna-seq whole-genome targeted pcr-based

• Blood-based epigenetic instability linked to human aging and disease.

  PMID 41690920 · PMC13018287 · Nature communications · 2026 · 7 claims · 8 setups

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  31,744 unmethylated (and 6143 methylated) CpG loci in blood show highly consistent, stable methylation in young healthy individuals and are defined as Epigenetically Stable Loci (ESLs)

  blood normal paired aml illumina whole-genome methylation

• Machine learning algorithm predicts fibrosis-related blood diagnosis markers of intervertebral disc degeneration.

  PMID 37915003 · PMC10619283 · BMC medical genomics · 2023 · 8 claims · 7 setups

  Has reproduction · 68

  CEP120 and SPDL1 were identified as diagnostic genes for IDD using a random forest model

  blood gse150408 cep120 pbmcs bulk machine single-sample

• External contamination in single cell mtDNA analysis.

  PMID 17668059 · PMC1930155 · PloS one · 2007 · 8 claims · 6 setups

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  External DNA contamination is a real and non-negligible problem in single-cell mtDNA sequence analysis

  single current laboratory reagent mtdna two-step nested

• Assessing individual differences in genome-wide gene expression in human whole blood: reliability over four hours and stability over 10 months.

  PMID 19653838 · PMC3819565 · Twin research and human genetics : the official journal of the International Society for Twin Studies · 2009 · 8 claims · 5 setups

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  A subset of probesets (3,414) shows 4-hour test-retest reliability exceeding r=0.70 for detecting individual differences in gene expression.

  blood edta reliably genome-wide twin sub-type

• Single-molecule sequencing of an individual human genome.

  PMID 19668243 · PMC4117198 · Nature biotechnology · 2009 · 8 claims · 7 setups

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  Single-molecule sequencing without cloning, amplification or ligation can sequence an individual human genome on one instrument by a single operator in four runs

  genome staphylococcus single-molecule snp sanger

• Single-cell and spatial profiling of peripheral blood and synovium unveils pro-arthritis CNBP(+) myeloid cells.

  PMID 41928282 · PMC13169754 · Journal of translational medicine · 2026 · 8 claims · 8 setups

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  Peripheral CNBP+ monocytes are expanded and show elevated 'inflammatory response' pathway scores in arthritis patients

  peripheral blood synovial arthritis single-cell bulk immunofluorescence

• Loss of Chromosome Y Associates With Altered Immune Cell Trajectories and X-Inactivation Features.

  PMID 42070154 · PMC13135724 · Aging cell · 2026 · 8 claims · 5 setups

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  LOY has cell type-specific effects on immune cells, with the highest prevalence in classical monocytes, that vary along differentiation trajectories

  peripheral blood classical cd4+ single-cell snp differential

• Innate antiviral and immune functions associated with the HIV reservoir decay after anti-PD-1 therapy.

  PMID 41680482 · PMC12920136 · Nature medicine · 2026 · 7 claims · 7 setups

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  Anti-PD-1 therapy triggers a rapid (within 24 hours) systemic cascade of increased IFN/antiviral, monocyte, and CD8+ T cell effector transcriptomic modules alongside decreased plasma TGFβ.

  pbmcs plasma pbmc publicly bulk plasma integrated

• Single-cell transcriptomics identifies regulatory T cell heterogeneity in gestational diabetes mellitus.

  PMID 41933176 · PMC13223204 · Communications medicine · 2026 · 8 claims · 8 setups

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  Treg cluster proportions do not significantly differ between GDM and healthy control patients

  sorted pbmcs treg gdm-patient single-cell mass gene

• Integrating genomic based information into clinical warfarin (Coumadin) management: an illustrative case report.

  PMID 18763667 · PMC3696193 · Connecticut medicine · 2008 · 8 claims · 6 setups

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  Combined CYP2C9 and VKORC1 genotype can explain up to 45% of warfarin dose variability

  genomic edta plasma cardiac genotyping extraction inr

• TARPON-A Telomere Analysis and Research Pipeline Optimized for Nanopore.

  PMID 41637390 · PMC12871981 · PLoS computational biology · 2026 · 7 claims · 6 setups

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  TARPON is the first complete, experimentally validated end-to-end pipeline for Nanopore-based telomere analysis requiring no data pre-processing or prior bioinformatics expertise.

  hg002 blood hek pod5 ont read capture

• Bisphenol a exposure and major depressive disorder: an integrative analysis combining network toxicology, molecular docking, genetic epidemiology, and transcriptomic validation.

  PMID 41912493 · PMC13039830 · Translational psychiatry · 2026 · 8 claims · 8 setups

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  571 shared targets identified between BPA-associated (2554) and MDD-associated (4661) genes

  gene shared gwas gabaergic network ppi mendelian

• Genetic variants of surfactant proteins A, B, C, and D in bronchopulmonary dysplasia.

  PMID 17264398 · PMC3850613 · Disease markers · 2006 · 7 claims · 4 setups

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  Significant associations (p ≤ 0.01) were found between BPD subgroups and alleles of SP-B and SP-B-linked microsatellite markers, and haplotypes of SP-A, SP-D, and SP-B

  greek genomic family-based pyrosequencing pcr