Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 6

System / cell line: aav ✕ Assay: single-cell ✕ Clear

SLIT3 fragments orchestrate neurovascular expansion and thermogenesis in brown adipose tissue.

PMID 41881972 · PMC13018599 · Nature communications · 2026 · 8 claims · 8 setups

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Adipocyte progenitors secrete SLIT3, which is cleaved into SLIT3-N and SLIT3-C fragments that independently drive angiogenesis and sympathetic innervation, respectively

bat brown single-cell qpcr western
Spatial perturb-seq: single-cell functional genomics within intact tissue architecture.

PMID 41723140 · PMC13035813 · Nature communications · 2026 · 8 claims · 8 setups

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Spatial Perturb-Seq simultaneously measures whole transcriptome (cell type), CRISPR barcodes (perturbation), spatial coordinates, and cell-cell interactions through a single Stereo-seq and/or Xenium run.

hippocampus bone brain aav-transduced scrna-seq snrna-seq spatial
Tumour-brain crosstalk restrains cancer immunity via a sensory-sympathetic axis.

PMID 41639447 · PMC12935554 · Nature · 2026 · 8 claims · 8 setups

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Lung adenocarcinoma (LUAD) induces increased innervation and functional/transcriptional engagement of vagal sensory neurons (VSNs)

kras-g12d tumour-bearing vagal npy2r-ires-cre whole-mount aav neurite
A multi-omics features-based approach integrating immunogenicity and inflammation enhances immunotherapy benefit in clear cell renal cell carcinoma.

PMID 41640425 · PMC12864441 · Frontiers in cell and developmental biology · 2025 · 7 claims · 8 setups

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The TIs-ML multi-omics model predicts ICB response/survival in ccRCC with superior accuracy (AUC > 0.997) compared to single biomarkers like PD-L1 and TMB

autoimmune igan scrna-seq bulk bulk scrna-seq scissor-based
Identification and validation of key PANoptosis-related genes via integrative machine learning and single-cell sequencing in AILI.

PMID 41858622 · PMC12995703 · iScience · 2026 · 8 claims · 8 setups

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Cdkn1a and Pdk1 are key PANoptosis-related genes with high diagnostic potential for AILI

liver training bulk wgcna machine
Olfactory epithelium organoid models identify Ddit3 as a potential therapeutic target against inflammation-related olfactory sensory neuronal loss and functional deficit.

PMID 42088417 · PMC13137857 · International journal of biological sciences · 2026 · 8 claims · 8 setups

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Three inflammatory OE organoid models (LPS instillation, TNFα treatment, doxycycline induction) were established and mimic impaired cell proliferation and neuronal genesis seen in olfactory inflammation

organoid organoids ddit3 olfactory organoid bulk aav-shrna

Experiments

SLIT3 fragments orchestrate neurovascular expansion and thermogenesis in brown adipose tissue.

Spatial perturb-seq: single-cell functional genomics within intact tissue architecture.

Tumour-brain crosstalk restrains cancer immunity via a sensory-sympathetic axis.

A multi-omics features-based approach integrating immunogenicity and inflammation enhances immunotherapy benefit in clear cell renal cell carcinoma.

Identification and validation of key PANoptosis-related genes via integrative machine learning and single-cell sequencing in AILI.

Olfactory epithelium organoid models identify Ddit3 as a potential therapeutic target against inflammation-related olfactory sensory neuronal loss and functional deficit.