Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• FEDRANN: effective long-read overlap detection based on dimensionality reduction and approximate nearest neighbors.

  PMID 42102720 · PMC13201080 · GigaScience · 2026 · 8 claims · 6 setups

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  A pipeline combining IDF transformation, sparse random projection (SRP), and NNDescent (the FEDRANN strategy) enables accurate overlap detection across diverse long-read datasets

  real same chromosome genome overlap exact simulated

• sedimix: a workflow for the analysis of hominin nuclear DNA sequences from sediments.

  PMID 41512286 · PMC12866666 · Bioinformatics (Oxford, England) · 2026 · 8 claims · 6 setups

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  sedimix is a snakemake workflow that processes raw sediment DNA sequencing reads (fastq) through filtering, taxonomic classification, mapping, and duplicate/quality filtering to output hominin-derived BAM files and summary statistics.

  simulated 000-year-old cervid gargammel-simulated metagenomic shotgun

• MECOM Function Is Critical for AR-Driven Treatment-Resistant Prostate Cancer.

  PMID 41529070 · PMC13136877 · Cancer research · 2026 · 7 claims · 8 setups

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  EVI1, encoded by MECOM, is an AR-recruited coactivator of noncanonical AR signaling in prostate cancer.

  lrex lucap167 prostate live-cell spheroid patient-derived

• omnideconv: a unifying framework for using and benchmarking single-cell-informed deconvolution of bulk RNA-seq data.

  PMID 41582216 · PMC12837286 · Genome biology · 2026 · 8 claims · 6 setups

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  omnideconv is an R package providing a unified interface to twelve second-generation deconvolution methods (AutoGeneS, BayesPrism, Bseq-SC, Bisque, CDseq, CIBERSORTx, CPM, DWLS, MOMF, MuSiC, SCDC, Scaden)

  blood-derived pbmc blood spleen bulk scrna-seq pseudo-bulk

• The genome sequence of the Chalk Yellow-face Bee, Hylaeus dilatatus (Kirby, 1802) (Hymenoptera: Colletidae).

  PMID 41657665 · PMC12881847 · Wellcome open research · 2026 · 8 claims · 8 setups

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  A two-haplotype genome assembly of Hylaeus dilatatus was produced, with total lengths of 307.38 Mb (haplotype 1) and 314.32 Mb (haplotype 2)

  hylaeus pacbio assembled barcoding pacbio hi-c

• The genome sequence of Menetries' Clouded Yellow, Colias thisoa Ménétriès, 1832 (Lepidoptera: Pieridae).

  PMID 41716938 · PMC12914173 · Wellcome open research · 2026 · 8 claims · 7 setups

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  A chromosome-level, haplotype-resolved genome assembly was generated for Colias thisoa as part of Project Psyche

  colias pacbio assembled scaffolded pacbio hi-c k-mer

• Disruption of tRNA threonylation triggers RIG-I mediated anti-tumour immune response.

  PMID 41735308 · PMC13043769 · Nature communications · 2026 · 8 claims · 8 setups

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  OSGEP is the catalytic subunit of the KEOPS complex responsible for t6A modification at position 37 of cytoplasmic tRNAs, and its loss causes the highest protein aggregation among 45 screened tRNA-modifying enzymes in melanoma cells

  mm117 b16f10 b16f10-derived c57bl esirna shrna rna-seq

• Multi-context seeds enable fast and high-accuracy read mapping.

  PMID 41764549 · PMC13059148 · Genome biology · 2026 · 7 claims · 5 setups

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  Multi-context seeds (MCS) allow storage of seeds with different lengths in the same index structure by splitting hash bits among strobes, enabling full and partial matches

  simulated chm13 same sequence seed simulated

• Parasitic connections: a patescibacterial epibiont, its methylotrophic gammaproteobacterial host, and their phages.

  PMID 41805398 · PMC13059738 · mBio · 2026 · 8 claims · 7 setups

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  Strigamonas methylophilicida sp. nov. is a new patescibacterial genus and species within the family Absconditicoccaceae

  freshwater fixed rsa individual phase transmission fluorescence-activated

• The chromosomal genome sequence of the carnivorous sponge, Lycopodina hypogea (Vacelet & Boury-Esnault, 1996) (Poecilosclerida: Cladorhizidae) and its associated microbial metagenome sequences.

  PMID 41835092 · PMC12988363 · Wellcome open research · 2026 · 7 claims · 7 setups

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  A chromosome-level genome assembly of Lycopodina hypogea was generated, with total length 235.10 Mb and 98.85% of sequence scaffolded into 15 chromosomal pseudomolecules.

  lycopodina microbial hypogea pacbio hi-c rna-seq

• Discovering and protecting cryptic biodiversity: A case study of a previously undescribed, vulnerable bird species in Japan.

  PMID 41852645 · PMC12993812 · PNAS nexus · 2026 · 8 claims · 8 setups

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  The Tokara Islands population is a cryptic species new to science, morphologically similar to but genetically distinct from Ijima's Leaf Warbler on the Izu Islands

  museum ijimae phylloscopidae genome-wide morphometric bioacoustic whole-genome

• Mapping human pre-rRNA processing and modification at single nucleotide resolution using long read nanopore sequencing.

  PMID 41916977 · PMC13201660 · Nature communications · 2026 · 8 claims · 8 setups

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  NanoRibolyzer, a nanopore-based long-read cDNA sequencing approach, enables ab initio identification and quantification of pre-rRNA precursors while simultaneously mapping RNA modifications

  hek293 long-read density-gradient dapi

• PeakPrime: a peak-guided primer design pipeline for target enrichment in 3'-end RNA-seq.

  PMID 41919010 · PMC13034549 · Bioinformatics advances · 2026 · 8 claims · 7 setups

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  PeakPrime is a reproducible Nextflow pipeline that calls 3′ RNA-seq coverage peaks (MACS2), selects exonic windows, designs strand-appropriate primers (Primer3), and screens specificity (Bowtie2)

  imr-32 universal candidate 10m-read rna-seq targeted quantitative

• The genome sequence of the Basking Shark, Cetorhinus maximus (Gunnerus, 1765) (Lamniformes: Cetorhinidae).

  PMID 41938266 · PMC13044535 · Wellcome open research · 2026 · 8 claims · 7 setups

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  The Cetorhinus maximus genome was assembled into two haplotypes with total lengths of 3993.85 Mb (hap1) and 3817.33 Mb (hap2)

  heart pacbio assembled pacbio hi-c rna-seq

• Full-length 16S rRNA nanopore sequencing enables species resolution of Fusobacterium associated with colorectal cancer.

  PMID 41963777 · PMC13078227 · Gut microbes · 2026 · 8 claims · 7 setups

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  Full-length 16S rRNA ONT sequencing combined with custom demultiplexing (nanoMux) enables robust species-level discrimination within the Fusobacterium genus

  gtdb rrndb zymobiomics host-bacteria ani phylogenetic 16s

• CLUES A Comprehensive Workflow for Integrating Geospatial Data in Biomedical Research.

  PMID 42128886 · PMC13172076 · Nature communications · 2026 · 8 claims · 5 setups

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  CLUES is an open-source, end-to-end workflow that automates selection, download, harmonization, and linkage of open-access geospatial environmental data to individual-level biomedical data without requiring geospatial expertise.

  national copernicus digital norwegian large-scale download spatial

• BioProEV: A Bioinformatics Pipeline for Biologically-Relevant Handling of Missing Values in the Analysis of Extracellular Vesicles by Mass Spectrometry.

  PMID 42145897 · PMC13178795 · Journal of extracellular biology · 2026 · 7 claims · 6 setups

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  A three-step missing value handling pipeline (exclusion of high-missingness proteins, MNAR detection/replacement with value '1', Random Forest imputation for remaining values) preserves biologically relevant information in EV proteomics data

  bovine fbs-derived milk-derived lc-esi-ms nanoparticle transmission

• Lift&Add-rapid and robust addition of new species to alignments of conserved non-coding sequences.

  PMID 42203687 · PMC13224966 · Bioinformatics (Oxford, England) · 2026 · 7 claims · 5 setups

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  Lift&Add, a Snakemake/bash workflow combining UCSC liftOver, Liftoff, and MAFFT, enables rapid addition of new genome sequences to existing multi-species alignments of conserved elements without requiring new whole-genome alignments.

  mm10 opossum newly vertebrate phastcons ucsc liftoff

• Whole-genome sequencing with AVITI and NovaSeq X Plus reveals comparable performance with contextual biases.

  PMID 42206012 · PMC13202175 · NAR genomics and bioinformatics · 2026 · 8 claims · 7 setups

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  AVITI and NovaSeq X Plus are highly comparable overall for variant-calling performance in WGS

  tumor mm1s aviti chr20 whole-genome pacbio small

• Deep-learning prediction of gene expression from personal genomes.

  PMID 41495833 · PMC12869966 · Genome biology · 2026 · 8 claims · 8 setups

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  Fine-tuning Enformer on paired personal WGS and RNA-seq data (Variformer) corrects Enformer's failure to predict inter-individual gene expression differences across held-out people.

  gtex rosmap same monocyte paired mutagenesis chromhmm