Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Single-nucleus multiomic profiling of the aging mouse substantia nigra reveals conserved gene alterations linked to Parkinson's disease.

  PMID 41781332 · PMC13138337 · Genome research · 2026 · 8 claims · 7 setups

  Full-text index only

  Single-nucleus multiome (RNA+ATAC) sequencing of mouse substantia nigra across four age stages (2, 6, 12, 18 months) yields a 40,125-cell atlas spanning 27 cell subclasses

  substantia allen five oligodendrocyte single-nucleus scrna-seq single-cell

• Single-nucleus epigenomic profiling of the adult human central nervous system unveils epigenetic memory of developmental programs.

  PMID 41857393 · PMC13061643 · Nature neuroscience · 2026 · 8 claims · 6 setups

  Full-text index only

  Adult spinal-cord-derived human oligodendroglia and astrocytes, but not microglia, show primed chromatin signatures at HOX loci and a putative SOX10 enhancer.

  postmortem induced lentiviral cns single-nucleus nanocut&tag high-resolution

• Single-nucleus ATAC-seq analysis resolves chromatin and transcriptional features of fibrolamellar carcinoma.

  PMID 41865105 · PMC13144680 · Scientific reports · 2026 · 8 claims · 5 setups

  Full-text index only

  snATAC-seq resolves cell-type specific chromatin accessibility, microRNA activity, transcription factor networks, and super enhancer usage in FLC tumors versus non-malignant liver (NML).

  flc bulk snatac-seq snrna-seq single-nucleus bulk motif

• Single-cell resolution of an open chromatin signature in persister tumor cells.

  PMID 41485222 · PMC12978573 · Cell reports · 2026 · 8 claims · 8 setups

  Full-text index only

  Single-nucleus multi-omic (snRNA-seq + snATAC-seq) profiling of fallopian tube, treatment-naive, and NACT-treated HGSOC tissue identifies a persister cell signature (PCS) defining the chemotherapy-tolerant state.

  non-malignant same epithelial tumor single-nucleus mitochondrial copy-number

• Genetics and environment distinctively shape the human immune cell epigenome.

  PMID 41593234 · PMC12900638 · Nature genetics · 2026 · 8 claims · 6 setups

  Full-text index only

  Exposure-associated differentially methylated regions (eDMRs) and genotype-associated DMRs (gDMRs) show distinct genomic distributions: eDMRs are enriched at enhancers/regulatory regions, while gDMRs are predominantly found in gene bodies.

  pbmcs pbmc edmrs differentially single-nucleus fluorescence-activated motif

• Regulatory-like FOXP3+Helios+CD4+ T conventional cells correlate with T-cell activation after Orca-T immunotherapy.

  PMID 41758930 · PMC13197979 · Blood · 2026 · 8 claims · 6 setups

  Full-text index only

  Orca-T immunotherapy leads to increased phenotypic T-cell activation compared with unmanipulated PBSC grafts, persisting for months after treatment.

  peripheral sorted fresh cryopreserved flow single-cell tcr

• Tet2 modulates ER stress responses related to β-cell death and autoimmunity in diabetes.

  PMID 41782826 · PMC12955150 · iScience · 2026 · 8 claims · 6 setups

  Full-text index only

  Tet2-deficient NOD mice transplanted with WT bone marrow show fewer islet-infiltrating lymphocytes beginning 8–10 weeks post-transplant, primarily among CD4+ T cells

  islets islet islet-infiltrating cadaveric flow single-cell single-nucleus

• Shared genetic and neuroimmune architecture links type 1 diabetes with neurocognitive traits.

  PMID 41826324 · PMC13139607 · Nature communications · 2026 · 8 claims · 8 setups

  Full-text index only

  T1D GWAS heritability is enriched in accessible chromatin of brain-resident cells, most notably microglia, across neurodevelopment into adulthood

  cortex single-nucleus gwas gtex stratified scavenge s-ldsc

• YAP/TAZ-VGLL3 governs adipocyte fate via epigenetic reprogramming of PPARγ and its target enhancers.

  PMID 41533786 · PMC12802833 · Science advances · 2026 · 8 claims · 8 setups

  Full-text index only

  TAZ represses PPARγ-bound target enhancers, evidenced by markedly reduced H3K27ac occupancy, leading to transcriptional repression of adipogenic genes including Pparg2

  c3h10t1 inguinal iwat adipose atac-seq rna-seq immunoblot

• Single-cell epigenomics uncovers heterochromatin instability and transcription factor dysfunction during mouse brain aging.

  PMID 41824460 · PMC13189690 · Cell reports · 2026 · 8 claims · 6 setups

  Full-text index only

  Aging causes widespread, concordant changes in chromatin accessibility and gene expression across neuronal and glial cell types in the mouse brain

  brain snatac-seq single-nucleus merfish

• Single-cell spatiotemporal dissection of the human maternal-fetal interface.

  PMID 41951740 · PMC13149032 · Nature · 2026 · 8 claims · 8 setups

  Full-text index only

  Generated a comprehensive single-cell multiomic and spatial atlas of the human maternal-fetal interface from early gestation to term

  decidua maternal-fetal pseudobulk trophoblast paired genotype snatac-seq

• Dominant clones leverage developmental epigenomic states to drive ependymoma.

  PMID 41882368 · PMC13102692 · Nature · 2026 · 8 claims · 8 setups

  Full-text index only

  Chromatin accessibility patterns in neural progenitor cells are pre-established during normal development and are subsequently commissioned (not created) by ZR binding to drive oncogene expression

  rgcs ha-tagged developing native-forming bulk csi snmultiome