Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Single-nucleus multiomic profiling of the aging mouse substantia nigra reveals conserved gene alterations linked to Parkinson's disease.

  PMID 41781332 · PMC13138337 · Genome research · 2026 · 8 claims · 7 setups

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  Single-nucleus multiome (RNA+ATAC) sequencing of mouse substantia nigra across four age stages (2, 6, 12, 18 months) yields a 40,125-cell atlas spanning 27 cell subclasses

  substantia allen five oligodendrocyte single-nucleus scrna-seq single-cell

• Single-nucleus ATAC-seq analysis resolves chromatin and transcriptional features of fibrolamellar carcinoma.

  PMID 41865105 · PMC13144680 · Scientific reports · 2026 · 8 claims · 5 setups

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  snATAC-seq resolves cell-type specific chromatin accessibility, microRNA activity, transcription factor networks, and super enhancer usage in FLC tumors versus non-malignant liver (NML).

  flc bulk snatac-seq snrna-seq single-nucleus bulk motif

• Shared genetic and neuroimmune architecture links type 1 diabetes with neurocognitive traits.

  PMID 41826324 · PMC13139607 · Nature communications · 2026 · 8 claims · 8 setups

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  T1D GWAS heritability is enriched in accessible chromatin of brain-resident cells, most notably microglia, across neurodevelopment into adulthood

  cortex single-nucleus gwas gtex stratified scavenge s-ldsc

• Single cell multiomics revealed fibrotic trajectories of endometrial cells and interaction with the pro-fibrotic macrophages in intrauterine adhesion.

  PMID 41947225 · PMC13188631 · Genome medicine · 2026 · 8 claims · 8 setups

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  Human IUA endometrium contains a novel ACTA2+KRT8+ myofibrotic-epithelial subpopulation and an ACTA2+CD31+ myofibrotic-endothelial subpopulation, in addition to myofibroblasts

  endometrial iua scrna-seq snatac-seq spatial

• Gene regulatory network determinants of rapid recall in human memory CD4(+) T cells.

  PMID 41865369 · PMC13207208 · Cell reports · 2026 · 8 claims · 6 setups

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  Memory CD4+ T cells show enhanced chromatin accessibility proximal to rapid-recall genes compared to naive cells

  blood-derived computational pseudobulk cd4+ single-nuclei maxatac grn

• A longitudinal single-cell and spatial multiomic atlas of pediatric high-grade glioma.

  PMID 42030938 · PMC13198283 · Cell reports. Medicine · 2026 · 8 claims · 8 setups

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  A multiomic (snRNA-seq, snATAC-seq, WGS, CODEX) atlas defines a core set of pHGG neoplastic cell states shared across molecular subtypes

  phgg neoplastic fetal single-nucleus whole-genome codex

• An integrative single-nucleus multiomic atlas of the human left ventricle identifies gene regulatory network dynamics across cardiac development, aging, and disease.

  PMID 41937210 · PMC13067603 · Genome biology · 2026 · 8 claims · 8 setups

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  Constructed an integrated multiomic atlas of the human left ventricle combining ~2.3M snRNA-seq nuclei from 299 donors and ~690K snATAC-seq nuclei from 106 donors

  left heart cardiac snrna-seq snatac-seq bulk

• Genetics and environment distinctively shape the human immune cell epigenome.

  PMID 41593234 · PMC12900638 · Nature genetics · 2026 · 8 claims · 6 setups

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  Exposure-associated differentially methylated regions (eDMRs) and genotype-associated DMRs (gDMRs) show distinct genomic distributions: eDMRs are enriched at enhancers/regulatory regions, while gDMRs are predominantly found in gene bodies.

  pbmcs pbmc edmrs differentially single-nucleus fluorescence-activated motif