Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Reliable Inference of Phylogenomic Relationship via Assembly-Based Strategy Accommodating Raw Reads and Proteins.

  PMID 41800729 · PMC12969758 · Molecular ecology resources · 2026 · 7 claims · 8 setups

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  VEHoP infers protein-coding regions from diverse input types (raw reads, draft genomes, transcriptomes, annotated genomes) and automates generation of orthologous alignments, concatenated supermatrices, and phylogenetic trees in a single pipeline run.

  ostreida crassostrea catfish insects phylogenomic sequencing reduced

• Evolutionary genomic basis of mimicry diversity of Epicopeiidae moths.

  PMID 41802886 · PMC13014123 · Molecular biology and evolution · 2026 · 8 claims · 8 setups

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  Genomic structural variations and gene family expansions contributed little to morphological (mimicry) evolution in Epicopeiidae

  epicopeiidae mencia ancestral chromosome-level whole-genome hi-c comparative

• Signatures of Innovation and Selection in the Extremotolerant Yeast Kluyveromyces marxianus.

  PMID 41874284 · PMC13011806 · Genome biology and evolution · 2026 · 8 claims · 9 setups

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  K. marxianus shows a unique stress-resistance syndrome (heat, ethanol, caffeine, propidium iodide, MMS) relative to other Kluyveromyces species

  kluyveromyces marxianus one-to-one liquid heat-shock stress

• Centromeric retrotransposons shape chromosomal evolution beyond pericentromeric regions.

  PMID 41923128 · PMC13169781 · Mobile DNA · 2026 · 8 claims · 8 setups

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  Specialized CRM retrotransposon elements specifically target active centromeres and are surrounded by Athila element copies

  biscutella varia austriaca unassembled long-read short-read hi-c

• Transcript diversity reflects deleterious RNA processing errors shaped by population size in metazoans.

  PMID 41988943 · PMC13001929 · PLoS biology · 2026 · 8 claims · 8 setups

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  Transcript diversity caused by APA, ATI, and AS decreases with Ne (and correspondingly increases with the Ne proxies life span, body length, and omega) across metazoan species.

  metazoan cd4 3'-end-seq rna-seq cage-seq

• ProtoCloud: A prototypical self-explaining model for single-cell analysis.

  PMID 41997134 · PMC13261663 · Cell genomics · 2026 · 8 claims · 8 setups

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  ProtoCloud matches or outperforms existing annotation methods across 11 large-scale datasets, particularly for rare cell types

  diverse pbmc10k pbmc30k tsca scrna-seq latent gene

• TrichoBase: a standardized genomic resource for comparative genomics of Trichoderma species.

  PMID 42098613 · PMC13196189 · BMC genomic data · 2026 · 6 claims · 8 setups

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  Developed a unified, evidence-based annotation pipeline integrating RNA-seq and homology data applied to six Trichoderma species, producing 'TrichoBase', a standardized genomic resource

  trichoderma fungal genome average repeat

• How bacterial communities expand functional repertoires.

  PMID 17238278 · PMC1750926 · PLoS biology · 2006 · 8 claims · 7 setups

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  The human microbiome contains roughly 100 times as many genes as does the human genome

  bacteroides distal interleukin-10-deficient macrophages transcriptional metagenomic microbiota

• The selection of software and database for metagenomics sequence analysis impacts the outcome of microbial profiling and pathogen detection.

  PMID 37027361 · PMC10081788 · PloS one · 2023 · 7 claims · 7 setups

  Has reproduction · 86

  Obtaining an accurate species-level microbial profile using current direct-read metagenomics profiling software is still a challenging task.

  simulated kidney biological extracted shotgun taxonomic pathogen

• Advancing codon language modeling with synonymous codon constrained masking.

  PMID 41736545 · PMC12956333 · Nucleic acids research · 2026 · 8 claims · 7 setups

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  SynCodonLM introduces synonymous codon-constrained masking, restricting masked-codon prediction to only synonymous codon options via logit masking before softmax

  cds syncodonlm escherichia rscu masked t-sne pca

• Comparative genomics of fungal allergens and epitopes shows widespread distribution of closely related allergen and epitope orthologues.

  PMID 17029625 · PMC1613252 · BMC genomics · 2006 · 8 claims · 3 setups

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  A database of 82 allergen sequences was compiled and used to search 22 fungal genomes for orthologues.

  fungal fumigatus enolase comparative epitope

• DBD--taxonomically broad transcription factor predictions: new content and functionality.

  PMID 18073188 · PMC2238844 · Nucleic acids research · 2008 · 8 claims · 3 setups

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  DBD is a database of predicted sequence-specific DNA-binding transcription factors covering over 700 publicly available proteomes, up from 150 in the initial version.

  proteomes eukaryotic genomes hmm-based comparative heatmap

• Analyses of deep mammalian sequence alignments and constraint predictions for 1% of the human genome.

  PMID 17567995 · PMC1891336 · Genome research · 2007 · 7 claims · 3 setups

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  Four different alignment methods show large-scale consistency but substantial differences in small-scale rearrangements, sensitivity, and specificity.

  mammalian aligned constrained sequence evolutionary comparative

• lncEvo: automated identification and conservation study of long noncoding RNAs.

  PMID 33563213 · PMC7871587 · BMC bioinformatics · 2021 · 8 claims · 5 setups

  Has reproduction · 61

  lncEvo is an integrated Nextflow/Docker pipeline combining transcriptome assembly, lncRNA identification, and cross-species conservation analysis into a single workflow.

  chimp assembled pairwise raw bulk lncrna comparative

• Using multiple alignments to improve seeded local alignment algorithms.

  PMID 16100379 · PMC1185574 · Nucleic acids research · 2005 · 8 claims · 2 setups

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  Using information implicit in a multiple alignment to dynamically build a spaced-seed index weighted toward promising regions increases sensitivity of local alignment search compared to indexing a sequence alone

  alignment query leave-one-species-out seeded

• An XML standard for the dissemination of annotated 2D gel electrophoresis data complemented with mass spectrometry results.

  PMID 15005801 · PMC341449 · BMC bioinformatics · 2004 · 7 claims · 3 setups

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  An XML schema called Annotated Gel Markup Language (AGML) is proposed to manage, analyze, and disseminate annotated 2D gel electrophoresis and MS results.

  biological 2de agml gel mass visualization

• Draft Genome Sequences of Antimicrobial-Resistant Shigella Clinical Isolates from Pakistan.

  PMID 31346012 · PMC6658682 · Microbiology resource announcements · 2019 · 6 claims · 7 setups

  Has reproduction · 92

  Draft genome sequences of three multidrug-resistant Shigella clinical isolates from Pakistan (two S. flexneri, one S. sonnei) are reported as a resource for AMR surveillance.

  shigella bacterial antimicrobial whole-genome

• Expression Atlas update--a database of gene and transcript expression from microarray- and sequencing-based functional genomics experiments.

  PMID 24304889 · PMC3964963 · Nucleic acids research · 2014 · 8 claims · 6 setups

  Has reproduction · 84

  Expression Atlas is a value-added database providing gene, protein and splice variant expression across cell types, organism parts, developmental stages, diseases and other biological/experimental conditions, built from manually curated high-quality microarray and RNA-sequencing experiments from ArrayExpress.

  organisms arrayexpress-derived pride rna-sequencing single-channel two-colour

• NCBI Reference Sequence (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins.

  PMID 15608248 · PMC539979 · Nucleic acids research · 2005 · 7 claims · 5 setups

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  RefSeq provides a curated, non-redundant, explicitly linked collection of genomic, transcript and protein sequences spanning prokaryotes, eukaryotes and viruses.

  refseq honey sequence computational conserved

• A2TEA: Identifying trait-specific evolutionary adaptations.

  PMID 37224329 · PMC10186066 · F1000Research · 2022 · 8 claims · 7 setups

  Has reproduction · 90

  A2TEA integrates gene family expansion analysis with differential expression data across species to identify genes that were targets of evolutionary adaptation to a given stress/treatment

  user-provided multi-species genes sequences rna-seq orthologous phylogenetic