Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 9

System / cell line: luad ✕ Assay: specific ✕ Clear

Mitochondrial DNA methylation predicts immunotherapy response and prognosis in lung adenocarcinoma: evidence from scRNA-Seq and machine learning.

PMID 41663976 · PMC12997902 · BMC cancer · 2026 · 8 claims · 8 setups

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Differentially expressed MTDM-related genes (DEMTDMRGs) are significantly enriched in cell cycle regulation, ferroptosis, and ABC transporter pathways

luad demtdmrgs gse131907 wgcna kegg univariate
Multiomic and functional validation of ACSL3, a regulator of fatty acid metabolism, as a lymph node metastasis-associated gene in lung adenocarcinoma.

PMID 41998631 · PMC13261843 · Respiratory research · 2026 · 8 claims · 8 setups

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A five-gene FAM-related risk signature (ACSL3, MCAT, NDUFAB1, OLAH, ACSL4)-derived FScore stratifies LUAD prognosis across multiple independent cohorts

tcga-luad luad a549 lymphatic bulk scrna-seq spatial
Multi-Omics reveals SPP1 + malignant and CXCR4(+) TAM crosstalk predicts immunotherapy response in lung adenocarcinoma.

PMID 42045760 · PMC13187092 · Discover oncology · 2026 · 8 claims · 8 setups

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SPP1+ malignant and CXCR4+ TAM crosstalk drives CD8 T cell exhaustion and induces poor immunotherapy response

luad tcga-luad epithelial a549 single-cell spatial bulk
An integrated single-cell lung cancer atlas reveals distinct fibroblast phenotypes between adenocarcinoma and squamous cell carcinomas.

PMID 41577803 · PMC12920623 · NPJ precision oncology · 2026 · 8 claims · 8 setups

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Inflammatory CAFs (iCAFs) predominate in LUAD, whereas myofibroblastic CAFs (mCAFs) predominate in LUSC

nsclc epithelial macrophage caf scrna-seq copy gene-set
Tumour-brain crosstalk restrains cancer immunity via a sensory-sympathetic axis.

PMID 41639447 · PMC12935554 · Nature · 2026 · 8 claims · 8 setups

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Lung adenocarcinoma (LUAD) induces increased innervation and functional/transcriptional engagement of vagal sensory neurons (VSNs)

kras-g12d tumour-bearing vagal npy2r-ires-cre whole-mount aav neurite
Functional germline variants together with somatic mutations alter the integrity of cancer hallmark regulatory networks.

PMID 42057121 · PMC13151107 · Genome medicine · 2026 · 8 claims · 6 setups

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Combined germline and somatic alterations disturb cancer hallmark pathway integrity in individual-specific ways, potentially explaining unique clinical behavior of each cancer.

tcga cancer individual biological germline somatic crispr
Integrated spatial transcriptomics and pan-cancer XGBoost modeling uncover spatial drivers of immune exclusion and predict immunotherapy response.

PMID 41925746 · PMC13046951 · Cancer immunology, immunotherapy : CII · 2026 · 8 claims · 8 setups

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A three-step computational framework (ImmCeRNA) identified 6,070 immune-related ceRNA interactions across 27 cancer types by integrating expression correlation and experimental validation data.

cancer pan-cancer single lung bulk database single-cell
A novel deep learning-driven framework for improving lncRNA comprehensive annotation with LncADeep 2.0.

PMID 41923359 · PMC13090826 · Bioinformatics (Oxford, England) · 2026 · 8 claims · 8 setups

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LncADeep 2.0 outperforms LncADeep and other existing tools for lncRNA identification on both GENCODE annotated transcripts and independent RNA-seq data

lncrna hypertrophic gencode lncrna-protein-mirna mlp-based independent ablation
Evaluating deconvolution methods using real bulk RNA-expression data for robust prognostic insights across cancer types.

PMID 41566530 · PMC12906006 · Genome biology · 2026 · 7 claims · 6 setups

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Pseudobulk and real bulk RNA-seq deconvolution performance differ significantly, and method ranking consistency is lower between pseudobulk and real bulk than within either data type alone

breast real colon tcga paired pseudobulk bulk

Experiments

Mitochondrial DNA methylation predicts immunotherapy response and prognosis in lung adenocarcinoma: evidence from scRNA-Seq and machine learning.

Multiomic and functional validation of ACSL3, a regulator of fatty acid metabolism, as a lymph node metastasis-associated gene in lung adenocarcinoma.

Multi-Omics reveals SPP1 + malignant and CXCR4(+) TAM crosstalk predicts immunotherapy response in lung adenocarcinoma.

An integrated single-cell lung cancer atlas reveals distinct fibroblast phenotypes between adenocarcinoma and squamous cell carcinomas.

Tumour-brain crosstalk restrains cancer immunity via a sensory-sympathetic axis.

Functional germline variants together with somatic mutations alter the integrity of cancer hallmark regulatory networks.

Integrated spatial transcriptomics and pan-cancer XGBoost modeling uncover spatial drivers of immune exclusion and predict immunotherapy response.

A novel deep learning-driven framework for improving lncRNA comprehensive annotation with LncADeep 2.0.

Evaluating deconvolution methods using real bulk RNA-expression data for robust prognostic insights across cancer types.