Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Metabolism as a complex genetic trait, a systems biology approach: implications for inborn errors of metabolism and clinical diseases.

  PMID 18836848 · PMC4319114 · Journal of inherited metabolic disease · 2008 · 7 claims · 8 setups

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  Synergistic heterozygosity — cumulative heterozygous mutations at multiple loci in functionally related metabolic pathways — can cause physiologically relevant reduction of pathway flux and disease.

  models liver sucrose vlcad-deficient physiological blue sucrose

• Single-cell multiomics uncovers an endothelial mechanosensitive PIEZO1-IL-33 axis driving pulmonary fibrosis.

  PMID 41862476 · PMC13004862 · Nature communications · 2026 · 7 claims · 8 setups

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  Mechanical stress (MS) signaling is significantly elevated in endothelial cells (ECs) from IPF patients and correlates with fibrosis severity and lung function decline

  lung cd31+ single-nucleus scissor meta-analysis

• T cell-intrinsic VISTA expression promotes resistance to CTLA-4 blockade by restricting CD8+ T cell responses.

  PMID 41837284 · PMC12987620 · The Journal of clinical investigation · 2026 · 8 claims · 8 setups

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  Loss of T cell-intrinsic VISTA enhances early priming and short-term expansion of CD8+ T cells but this initial advantage fails to confer durable tumor control

  tumor vsir cell-specific myeloid-specific flow adoptive peptide

• Olfactory epithelium organoid models identify Ddit3 as a potential therapeutic target against inflammation-related olfactory sensory neuronal loss and functional deficit.

  PMID 42088417 · PMC13137857 · International journal of biological sciences · 2026 · 8 claims · 8 setups

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  Three inflammatory OE organoid models (LPS instillation, TNFα treatment, doxycycline induction) were established and mimic impaired cell proliferation and neuronal genesis seen in olfactory inflammation

  organoid organoids ddit3 olfactory organoid bulk aav-shrna

• Of mice and men: comparative proteomics of bronchoalveolar fluid.

  PMID 20032019 · PMC3049194 · The European respiratory journal · 2010 · 8 claims · 8 setups

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  Comparative shotgun proteomics of human and mouse BALF identifies conserved pathways (immunity, defence response, protease activity) alongside species-specific divergent pathways.

  pooled oxidative unpooled balf shotgun functional protein-protein

• Chromosome-scale genome assembly for yellow wood sorrel, Oxalis stricta.

  PMID 41482730 · PMC12958822 · G3 (Bethesda, Md.) · 2026 · 8 claims · 8 setups

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  O. stricta genome assembly is chromosome-scale, 436 Mb, spanning 12 chromosomes across 2 subgenomes

  stricta long-read short-read hi-c

• Single-Cell RNA Analysis of Murine Osteosarcoma Uncovers Skp2 Function in Metastasis, Genomic Instability, and Immune Activation and Reveals Additional Target Pathways.

  PMID 41877584 · PMC13103941 · Cancer research communications · 2026 · 8 claims · 6 setups

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  Skp2 KO improves survival, drives apoptosis, and induces antitumor immunity in Rb1/Trp53-deficient murine osteosarcoma

  tumors same osteosarcoma skp2 scrna-seq mutation copy-number

• SenSet defines cell-type specific senescence signatures in the aged human lung.

  PMID 41963555 · PMC13187336 · The EMBO journal · 2026 · 8 claims · 4 setups

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  SenSet comprises 106 genes identified by covariate-shift-aware positive-unlabeled (PUc) learning applied across single cells from the Human Lung Cell Atlas (HLCA)

  lung replicative hlca single-cell gene targeted

• Identification and Characterization of Small Noncoding RNAs in Genome Sequences of the Edible Fungus Pleurotus ostreatus.

  PMID 27703969 · PMC5040776 · BioMed research international · 2016 · 7 claims · 8 setups

  Has reproduction · 95

  Genome-scale identification detected 254 small noncoding RNAs (snRNAs, snoRNAs, tRNAs, miRNAs, and other Rfam-classified sncRNAs) in the P. ostreatus CCEF00389 genome assembly

  pleurotus ostreatus ccef00389 sncrnas whole-genome rna-seq rfam

• COVID-19 lung disease shares driver AT2 cytopathic features with Idiopathic pulmonary fibrosis.

  PMID 35870428 · PMC9297827 · EBioMedicine · 2022 · 8 claims · 8 setups

  Has reproduction · 85

  COVID-19 lung disease resembles IPF at a fundamental level, recapitulating ViP/IPF gene expression patterns, an IL15-centric cytokine storm, and AT2 cytopathic changes (injury, DNA damage, transient progenitor-state arrest, senescence/SASP).

  lung covid-19 interaction pre-clinical composite single-cell kaplan-meier

• The role of proteomics in depression research.

  PMID 19997739 · PMC2940035 · European archives of psychiatry and clinical neuroscience · 2010 · 8 claims · 8 setups

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  Proteomics offers a complementary, functional-endpoint approach that can elucidate MDD pathophysiological mechanisms and biomarkers beyond transcriptomic/targeted studies

  postmortem schizophrenia frontal hypothalamus gel shotgun proteome

• The genome of the reef-building coral Porites harrisoni from the southern Persian/Arabian Gulf.

  PMID 41929243 · PMC13040556 · GigaByte (Hong Kong, China) · 2026 · 8 claims · 8 setups

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  P. harrisoni from the southern PAG has a genome assembly of 626.7 Mb across 1,883 contigs with contig N50 of 807.4 kb

  porites long-read rna-seq k-mer