Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 26

System / cell line: fractions ✕ Assay: subcellular ✕ Clear

Proteomic and functional characterisation of platelet microparticle size classes.

PMID 19806257 · PMC2861410 · Thrombosis and haemostasis · 2009 · 8 claims · 8 setups

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PMP separated by gel filtration into 4 size classes differ in protein content, phospholipid/protein ratio, and functional effects on platelets and endothelial cells

pooled pmp citrated huvec gel dynamic lipid
Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics.

PMID 12213833 · PMC2173151 · The Journal of cell biology · 2002 · 8 claims · 8 setups

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Subcellular proteomics of purified CCVs identifies enthoprotin (encoded by KIAA0171), a novel ENTH domain-containing protein not previously detected at the protein level.

brain cos-7 hek-293 clathrin subcellular western ccv
A quantitative proteomics analysis of subcellular proteome localization and changes induced by DNA damage.

PMID 20026476 · PMC2849709 · Molecular & cellular proteomics : MCP · 2010 · 6 claims · 5 setups

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A SILAC-based 'spatial proteomics' method can quantitatively measure the relative subcellular distribution of thousands of proteins across cytoplasm, nucleus, and nucleolus.

hct116 silac silac-based immunofluorescence
Point mutations in GLI3 lead to misregulation of its subcellular localization.

PMID 19829694 · PMC2758996 · PloS one · 2009 · 6 claims · 8 setups

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The MID1-α4-PP2A complex regulates the subcellular localization and transcriptional activity of GLI3.

hela immunofluorescence real-time luciferase
RNA structure maps across mammalian cellular compartments.

PMID 30886404 · PMC6640855 · Nature structural & molecular biology · 2019 · 8 claims · 6 setups

Has reproduction · 45

icSHAPE-based cytotopic RNA structuromes across chromatin, nucleoplasm and cytoplasm in human and mouse cells substantially expand the scope of RNA structural information beyond whole-cell data.

v6.5 mes icshape rt-qpcr western
Proteomic analysis of stage I primary lung adenocarcinoma aimed at individualisation of postoperative therapy.

PMID 18212748 · PMC2243141 · British journal of cancer · 2008 · 5 claims · 6 setups

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LC-MS/MS proteomic analysis of stage I lung adenocarcinoma specimens identified myosin IIA and vimentin as candidate biomarker proteins with signal intensities that differed significantly among patient outcome groups

surgically tryptic set lysates lc-ms mascot immunohistochemistry
H-DBAS: human-transcriptome database for alternative splicing: update 2010.

PMID 19969536 · PMC2808982 · Nucleic acids research · 2010 · 8 claims · 4 setups

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RNA-Seq tags from the polysome fraction identify AS exons that are very likely used for protein synthesis

dld-1 rna-seq western real-time
Comparative genomic analysis reveals a novel mitochondrial isoform of human rTS protein and unusual phylogenetic distribution of the rTS gene.

PMID 16162288 · PMC1261261 · BMC genomics · 2005 · 8 claims · 5 setups

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A novel rTS protein isoform, rTSγ, exists with a 27-residue longer N-terminus generated from an alternative upstream start codon relative to rTSβ.

rts rtsβ ccrf-cem comparative mitochondrial subcellular
Reconstruction of pathways associated with amino acid metabolism in human mitochondria.

PMID 18267298 · PMC5054205 · Genomics, proteomics & bioinformatics · 2007 · 8 claims · 5 setups

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Out of 20 amino acids, the metabolic pathways of 17 utilize mitochondrial enzymes, and dysfunction of these enzymes causes over 40 known human mitochondrial diseases/disorders

mitoproteome orthologous liver mitochondrial sequence-based computational literature
A new paradigm for MAPK: structural interactions of hERK1 with mitochondria in HeLa cells.

PMID 19847302 · PMC2760858 · PloS one · 2009 · 8 claims · 8 setups

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hERK1 translocates to the mitochondria of HeLa cells upon a proliferative stimulus

hela confocal immunofluorescence western
CEBS--Chemical Effects in Biological Systems: a public data repository integrating study design and toxicity data with microarray and proteomics data.

PMID 17962311 · PMC2238989 · Nucleic acids research · 2008 · 8 claims · 5 setups

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CEBS is a public repository that integrates study design, timeline, clinical chemistry and histopathology data with microarray and proteomics data

subcellular laboratory cebs microarray gel clinical
HUPO Highlights.

PMID 19862759 · PMC4594800 · Proteomics · 2009 · 8 claims · 8 setups

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Mass spectrometry analysis of human liver reference samples (French Reference liver + Huh7 hepatoma cells) achieves substantial human genome coverage via PeptideAtlas processing

liver subcellular models fetal mass antibody-based quantitative
Quantitative membrane proteomics reveals new cellular targets of viral immune modulators.

PMID 17238276 · PMC1626102 · PLoS pathogens · 2006 · 8 claims · 8 setups

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SILAC-based quantitative membrane proteomics can identify novel targets of viral immunomodulators in an unbiased manner

hela silac immunoblot flow
CD70 (TNFSF7) is expressed at high prevalence in renal cell carcinomas and is rapidly internalised on antibody binding.

PMID 16892042 · PMC2360640 · British journal of cancer · 2006 · 6 claims · 6 setups

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CD70 was identified by proteomic analysis of plasma membrane preparations as highly expressed in A498 and SW839 RCC-derived cell lines

a498 frozen normal proteomics flow immunohistochemistry
Direct in-gel fluorescence detection and cellular imaging of O-GlcNAc-modified proteins.

PMID 18683930 · PMC2649877 · Journal of the American Chemical Society · 2008 · 7 claims · 5 setups

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Y289L GalT-mediated transfer of UDP-GalNAz followed by Cu(I)-catalyzed azide-alkyne cycloaddition enables selective, highly sensitive fluorescent/biotin labeling of O-GlcNAc-modified proteins

α-crystallin forebrain hela chemoenzymatic in-gel nanolc-ms
MAPU: Max-Planck Unified database of organellar, cellular, tissue and body fluid proteomes.

PMID 17090601 · PMC1781136 · Nucleic acids research · 2007 · 8 claims · 8 setups

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MAPU is a unified, freely accessible database integrating organellar, cellular, tissue and body fluid proteomes generated by high-resolution mass spectrometry.

urine tear seminal breast gel lc-ms3 in-depth
7SL RNA and signal recognition particle orchestrate a global cellular response to acute thermal stress.

PMID 39952919 · PMC11828898 · Nature communications · 2025 · 8 claims · 8 setups

Has reproduction · 93

Heat shock induces de novo transcription and nuclear accumulation of 7SL RNA together with SRP proteins, which then bind chromatin at promoters

embryonic nih3t3 pro-seq fractionation fluorescence
Cancer cells copy migratory behavior and exchange signaling networks via extracellular vesicles.

PMID 29907695 · PMC6068466 · The EMBO journal · 2018 · 8 claims · 8 setups

Has reproduction · 46

B16F1 and B16F10 melanoma subclones functionally exchange EVs in vivo, transferring Cre mRNA cargo detectable via a Cre-LoxP color-switch reporter system

co-injected b16f1 locally 16.5k intravital cre-loxp rt-pcr
Biochemical and functional characterization of the membrane association and membrane permeabilizing activity of the severe acute respiratory syndrome coronavirus envelope protein.

PMID 16507314 · PMC7111751 · Virology · 2006 · 7 claims · 8 setups

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Expression of SARS-CoV E protein in mammalian cells alters membrane permeability

hela sf9 hygromycin site-directed subcellular
The N-terminus and alpha-5, alpha-6 helices of the pro-apoptotic protein Bax, modulate functional interactions with the anti-apoptotic protein Bcl-xL.

PMID 17519046 · PMC1890283 · BMC cell biology · 2007 · 8 claims · 8 setups

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Deletion of the first 29 N-terminal amino acids (Bax 30-192) causes constitutive mitochondrial accumulation and high cytotoxicity that is poorly inhibited by Bcl-xL or Bcl-2.

jurkat drosophila hek apoptotic uas-gal4 western

Experiments

Proteomic and functional characterisation of platelet microparticle size classes.

Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics.

A quantitative proteomics analysis of subcellular proteome localization and changes induced by DNA damage.

Point mutations in GLI3 lead to misregulation of its subcellular localization.

RNA structure maps across mammalian cellular compartments.

Proteomic analysis of stage I primary lung adenocarcinoma aimed at individualisation of postoperative therapy.

H-DBAS: human-transcriptome database for alternative splicing: update 2010.

Comparative genomic analysis reveals a novel mitochondrial isoform of human rTS protein and unusual phylogenetic distribution of the rTS gene.

Reconstruction of pathways associated with amino acid metabolism in human mitochondria.

A new paradigm for MAPK: structural interactions of hERK1 with mitochondria in HeLa cells.

CEBS--Chemical Effects in Biological Systems: a public data repository integrating study design and toxicity data with microarray and proteomics data.

HUPO Highlights.

Quantitative membrane proteomics reveals new cellular targets of viral immune modulators.

CD70 (TNFSF7) is expressed at high prevalence in renal cell carcinomas and is rapidly internalised on antibody binding.

Direct in-gel fluorescence detection and cellular imaging of O-GlcNAc-modified proteins.

MAPU: Max-Planck Unified database of organellar, cellular, tissue and body fluid proteomes.

7SL RNA and signal recognition particle orchestrate a global cellular response to acute thermal stress.

Cancer cells copy migratory behavior and exchange signaling networks via extracellular vesicles.

Biochemical and functional characterization of the membrane association and membrane permeabilizing activity of the severe acute respiratory syndrome coronavirus envelope protein.

The N-terminus and alpha-5, alpha-6 helices of the pro-apoptotic protein Bax, modulate functional interactions with the anti-apoptotic protein Bcl-xL.