Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Single-cell and spatial profiling of peripheral blood and synovium unveils pro-arthritis CNBP(+) myeloid cells.

  PMID 41928282 · PMC13169754 · Journal of translational medicine · 2026 · 8 claims · 8 setups

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  Peripheral CNBP+ monocytes are expanded and show elevated 'inflammatory response' pathway scores in arthritis patients

  peripheral blood synovial arthritis single-cell bulk immunofluorescence

• Scalable Prediction of Acute Myeloid Leukemia Using High-Dimensional Machine Learning and Blood Transcriptomics.

  PMID 31918046 · PMC6992905 · iScience · 2020 · 8 claims · 8 setups

  Has reproduction · 96

  Assembled the largest reference blood gene expression profiling (GEP) dataset for AML to date: 12,029 samples from 105 studies across three platforms.

  peripheral datasets hg-u133 disjoint bulk machine deep

• An individualized causal framework for learning intercellular communication networks that define microenvironments of individual tumors.

  PMID 36548438 · PMC9822106 · PLoS computational biology · 2022 · 8 claims · 6 setups

  Has reproduction · 67

  An individualized Bayesian causal discovery framework can learn tumor-specific intercellular communication networks (ICNs) by combining single-cell gene expression module (GEM) discovery, bulk tumor deconvolution, and individualized causal network learning.

  hnscc cd45+ cd8+ tcga single-cell bulk pseudo-time

• Multi-omics reveal vitamin D regulation of immune-gut microbiome interactions and tolerogenic pathways in inflammatory bowel disease.

  PMID 41895287 · PMC13130636 · Cell reports. Medicine · 2026 · 8 claims · 7 setups

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  12 weeks of vitamin D treatment decreases disease activity scores and inflammatory markers (fecal calprotectin) and improves quality of life in IBD patients

  stool peripheral iga-bound ibd iga-seq igg-seq blood

• Classification of ALS molecular subtypes: a literature review on machine learning applications and their clinical value.

  PMID 41731547 · PMC13037183 · BMC medicine · 2026 · 8 claims · 5 setups

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  Unsupervised ML analysis of ALS transcriptomes consistently identifies molecular subtypes reflecting distinct biological processes, primarily oxidative stress (ALS-Ox) and glial activation/neuroinflammation (ALS-Glia), found in every study reviewed.

  post-mortem peripheral bulk rna-seq blood

• Early onset familial Alzheimer Disease with spastic paraparesis, dysarthria, and seizures and N135S mutation in PSEN1.

  PMID 18580586 · PMC2750842 · Alzheimer disease and associated disorders · 2008 · 8 claims · 8 setups

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  The PSEN1 N135S mutation causes EOFAD with an atypical phenotype including spastic dysarthria, limb spasticity, and seizures in addition to typical cognitive deficits

  archival medulla cortex hippocampus immunohistochemistry thioflavin-s pcr

• The Presence of CD11c+ B Cells with Potent Effector Memory Phenotype in Lung Adenocarcinoma Correlates with Overall Patient Survival.

  PMID 41686183 · PMC12988592 · Cancer immunology research · 2026 · 7 claims · 7 setups

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  CD79A is a reliable transcriptomic/protein quantifier of B lymphocytes across differentiation stages, unlike CD19/CD20 whose expression changes upon activation

  healthy tcga luad til-b flow bulk single-cell

• Lineage-Specific Disruption of Hematopoiesis by Oxaliplatin: Mechanisms of Erythropoietin Resistance and Immune Suppression.

  PMID 41868970 · PMC13005433 · Journal of hematology and oncology research · 2026 · 8 claims · 5 setups

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  Oxaliplatin induces coordinated, lineage-dependent suppression of hematopoiesis, strongest in erythroid and lymphoid lineages while neutrophils are relatively spared

  bone peripheral plasma bulk complete multiplex

• Divergent macrophage-regulated T cell states determine response to Bacillus Calmette-Guérin vaccine in high-risk bladder cancer.

  PMID 42081487 · PMC13262731 · The Journal of clinical investigation · 2026 · 8 claims · 8 setups

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  BCG responders show an increase in Th17-like Th1 CD4+ T cells with greater proinflammatory cytokine expression

  bladder pbmcs cd4+ separate scrna-seq trajectory flow

• Single-cell profiling reveals distinct populations of tumor-associated macrophages and metastatic tumor cells in breast cancer brain metastasis.

  PMID 42034645 · PMC13247122 · Cell death & disease · 2026 · 8 claims · 8 setups

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  Single-cell profiling of BCBM identifies 12 tumor-associated macrophage (TAM) subtypes and 5 metastatic tumor cell (MTC) subtypes with distinct transcriptional profiles

  brain breast scrna-seq tams scrna-seq bulk copy

• Inherited resilience to clonal hematopoiesis by modifying stem cell RNA regulation.

  PMID 41477881 · PMC12850507 · Science (New York, N.Y.) · 2026 · 8 claims · 8 setups

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  A haplotype at the 17q22 locus, tagged by the noncoding variant rs17834140-T, is a causal protective variant against CHIP and myeloid malignancies

  population hspcs cd34+cd45ra-cd90+ heterozygous gwas atac-seq crispr