Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Microarray analysis: genome-scale hypothesis scanning.

  PMID 14551912 · PMC212694 · PLoS biology · 2003 · 8 claims · 5 setups

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  Microarrays can be used to both test and generate hypotheses, not merely to fish for candidate genes.

  drosophila yeast diffuse breast microarray integrated gene

• Anti-CSF-1R therapy with combined immuno-chemotherapy coordinate an adaptive immune response to eliminate macrophage enriched triple negative breast cancers.

  PMID 41484081 · PMC12858953 · Nature communications · 2026 · 8 claims · 8 setups

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  Combined low-dose CTX + anti-CSF-1R (SNDX-ms6352) is highly effective against aggressive metastatic Trp53-null TNBC models with high macrophage infiltration, producing complete tumor regression in claudin-low models.

  trp53-null complete t12 cell-deficient imaging survival tumor

• The complement system contributes to the immunosuppressive microenvironment of uveal melanoma.

  PMID 41803879 · PMC13130498 · Journal of translational medicine · 2026 · 8 claims · 8 setups

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  Primary UM (pUM) preferentially expresses early complement pathway components over terminal membrane attack complex elements, with early factors showing prognostic significance.

  short-term metastatic normal pum bulk label-free single-cell

• Transcriptome- and phenotype-based epistasis analysis in Caenorhabditis elegans reveals daf-16/FoxO-dependent and independent effects of daf-2/InsR in L1 starvation and recovery.

  PMID 41528819 · PMC12958807 · G3 (Bethesda, Md.) · 2026 · 7 claims · 8 setups

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  Differential gene expression caused by disruption of daf-2/InsR during L1 starvation is daf-16-dependent.

  elegans bulk principal hierarchical

• Technical challenges in using human induced pluripotent stem cells to model disease.

  PMID 19951687 · PMC2921621 · Cell stem cell · 2009 · 8 claims · 8 setups

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  hiPSCs generated from patient somatic cells (skin, blood) can be differentiated into disease-relevant cell types to model disease pathogenesis in vitro

  ipscs humanized hemophilia parkinsonian tetraploid transplantation neuronal

• Stemming cancer: functional genomics of cancer stem cells in solid tumors.

  PMID 18561035 · PMC2758383 · Stem cell reviews · 2008 · 8 claims · 8 setups

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  Cancer stem cells are a minority tumor subpopulation that alone can maintain indefinite tumor growth, as shown by serial transplantation experiments

  solid fetal cd133+ breast facs neurosphere genome-wide

• Multi-Omic Profiling of T Cell-Mediated Rejection After Kidney Transplantation Reveals B Cell Receptor Repertoire Expansion and Its Prognostic Relevance.

  PMID 41467897 · PMC12752722 · FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026 · 8 claims · 8 setups

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  The BCR repertoire, particularly the IgG isotype, is significantly expanded in TCMR compared to stable renal function (STA) across independent renal transplant cohorts

  kidney healthy lp-1 bcr bulk triple

• The ubiquitin ligase KLHL6 drives resistance to CD8(+) T cell dysfunction.

  PMID 41535474 · PMC12979199 · Nature · 2026 · 8 claims · 8 setups

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  KLHL6 is a dual-negative regulator of both T cell exhaustion and mitochondrial dysfunction

  cd8+ cas9+ sgklhl6-transduced klhl6 bulk pooled flow

• A novel deep learning-driven framework for improving lncRNA comprehensive annotation with LncADeep 2.0.

  PMID 41923359 · PMC13090826 · Bioinformatics (Oxford, England) · 2026 · 8 claims · 8 setups

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  LncADeep 2.0 outperforms LncADeep and other existing tools for lncRNA identification on both GENCODE annotated transcripts and independent RNA-seq data

  lncrna hypertrophic gencode lncrna-protein-mirna mlp-based independent ablation