Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• T cell-intrinsic VISTA expression promotes resistance to CTLA-4 blockade by restricting CD8+ T cell responses.

  PMID 41837284 · PMC12987620 · The Journal of clinical investigation · 2026 · 8 claims · 8 setups

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  Loss of T cell-intrinsic VISTA enhances early priming and short-term expansion of CD8+ T cells but this initial advantage fails to confer durable tumor control

  tumor vsir cell-specific myeloid-specific flow adoptive peptide

• Loss of SOCS1 in Donor T Cells Exacerbates Intestinal GVHD by Driving a Chemokine-Dependent Pro-Inflammatory Immune Microenvironment.

  PMID 41580972 · PMC13042394 · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026 · 8 claims · 8 setups

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  T cell-specific Socs1 loss intrinsically drives pro-inflammatory T cell differentiation independent of antigen stimulation, with the strongest effects in CD8+ T cells

  cd45+ splenic cd8+ sorted single-cell flow bulk

• Translation factor eIF4G2 directs CD8(+) T cell lineage commitment by selectively enabling the IL-7 receptor response.

  PMID 41940334 · PMC13049607 · iScience · 2026 · 8 claims · 8 setups

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  eIF4G2 expression is markedly upregulated in DP thymocytes relative to DN thymocytes

  thymocytes peripheral eif4g2 cd4+cd8lo single-cell western flow

• ZFP148 is a transcriptional repressor of cytolytic effector CD8(+) T cell differentiation.

  PMID 41896465 · PMC13043298 · Nature immunology · 2026 · 8 claims · 8 setups

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  ZFP148 is enriched in CD8+ T progenitor (T PRO) cells and its expression declines during differentiation into effector (T EFF) and exhausted (T EX) cells

  p14 splenic cd8+ b16-gp scrna-seq flow tcr

• Loss of CD4(+) T cell-intrinsic arginase 1 accelerates Th1 response kinetics and reduces lung pathology during influenza infection.

  PMID 37572656 · PMC10576612 · Immunity · 2023 · 8 claims · 8 setups

  Has reproduction · 68

  Arg1 is highly and specifically induced in lung CD4+ T cells during in vivo influenza infection

  flow-sort-purified lung cd4+ congenically rna-seq flow expression

• MYC-induced USP10 stabilizes SOX4 to promote thymocyte proliferation and leukemia onset in mice.

  PMID 41927540 · PMC13216311 · Nature communications · 2026 · 8 claims · 8 setups

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  USP10 is dynamically expressed in thymocytes, peaking during proliferative stages of T cell development in both mouse and human

  thymocytes thymocyte t-all lin dub rt-qpcr single-cell