Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Fluent genomics with  plyranges and  tximeta.

  PMID 32528659 · PMC7243206 · F1000Research · 2020 · 6 claims · 3 setups

  Has reproduction · 69

  A three-step fluent genomics workflow (import, model, integrate) using plyranges and tximeta provides a coherent, reproducible framework for integrating RNA-seq and ATAC-seq data within the Bioconductor ecosystem.

  ipsc-derived macrophage bulk atac-seq transcript

• Dynamics and regulation of mitotic chromatin accessibility bookmarking at single-cell resolution.

  PMID 36696508 · PMC9876548 · Science advances · 2023 · 7 claims · 8 setups

  Has reproduction · 50

  Chromatin accessibility continually decreases from mitotic entry until metaphase, then gradually increases as chromosomes segregate.

  l02 tissues hepatoma scatac-seq immunofluorescence atac-see

• Generic injuries are sufficient to induce ectopic Wnt organizers in Hydra.

  PMID 33779545 · PMC8049744 · eLife · 2021 · 8 claims · 5 setups

  Has reproduction · 100

  The initial transcriptional response to amputation is identical during head and foot regeneration at 3 hpa

  hydra atac-seq rna-seq chromvar

• Epigenomic, transcriptomic, and proteomic characterization of breast cancer cell line reference samples.

  PMID 41539304 · PMC12853167 · Cell reports methods · 2026 · 8 claims · 5 setups

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  Comprehensive multi-omics reference materials (ATAC-seq, Methyl-seq, RNA-seq, MS-proteomics) were generated for paired HCC1395/HCC1395BL cell lines as a community benchmarking resource

  hcc1395 atac-seq methyl-seq bulk

• Functional genomics analysis of developing zebrafish and human endoderm reveals highly conserved cis-regulatory modules acting during vertebrate organogenesis.

  PMID 41781333 · PMC7619044 · Genome research · 2026 · 8 claims · 8 setups

  Full-text index only

  There are few endoderm-specific CRMs; many CRMs governing pancreas development also likely act within the nervous system

  zebrafish embryonic atac-seq bulk facs

• Endogenous retroviruses mediate transcriptional rewiring in response to oncogenic signaling in colorectal cancer.

  PMID 39018396 · PMC466953 · Science advances · 2024 · 8 claims · 8 setups

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  Primate-specific ERVs are a rich source of enhancers displaying cancer-specific activity across multiple tumor types

  cancer hct116 tcga colorectal atac-seq chip-seq bulk

• The evolution of gene regulation in mammalian cerebellum development.

  PMID 41610256 · PMC7618896 · Science (New York, N.Y.) · 2026 · 8 claims · 8 setups

  Full-text index only

  Combined single-nucleus RNA-seq and ATAC-seq atlases of cerebellum development were generated/integrated across six mammals (human, bonobo, macaque, marmoset, mouse, opossum)

  developing opossum marmoset cultures single-nucleus bulk gene

• Manipulation of Alternative Splicing of IKZF1 Elicits Distinct Gene Regulatory Responses in T Cells.

  PMID 41677588 · PMC12896614 · Cells · 2026 · 8 claims · 6 setups

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  Alternative splicing of IKZF1 in human T cells strongly influences gene expression, chromatin accessibility, and protein production.

  jurkat genomic cd4+ rna-seq atac-seq immunoblotting

• Gene Regulatory Interactions at Lamina-Associated Domains.

  PMID 36833261 · PMC9957430 · Genes · 2023 · 8 claims · 8 setups

  Has reproduction · 31

  Active genes in constitutive LADs (cLADs) reside in euchromatic regions with low LMNB1 and LMNA/C enrichment, i.e., are locally detached from the nuclear lamina

  adipose ascs mesenchymal chip-seq rna-seq atac-seq

• PPDPF is not a key regulator of human pancreas development.

  PMID 40193385 · PMC12037078 · PLoS genetics · 2025 · 8 claims · 8 setups

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  PPDPF is not a key regulator of human pancreas development, in contrast to its zebrafish orthologue exdpf

  fetuses fetal hesc population situ proteome qpcr

• HIF sustain a transcriptional regulatory circuit of EPAS1 expression in renal clear cell carcinoma.

  PMID 41714613 · PMC12921326 · Nature communications · 2026 · 8 claims · 8 setups

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  HIF-2α mRNA is specifically overexpressed in ccRCC tumor tissue/cells compared to normal kidney, while it is reduced in papillary and chromophobe RCC

  erlangen tcga ccrcc tubule qpcr rna-seq rnascope

• Allelic variation at a single locus distinguishes spring and winter faba beans.

  PMID 41807799 · PMC12987728 · Nature genetics · 2026 · 8 claims · 8 setups

  Full-text index only

  GWAS identifies a major winter hardiness locus whose most strongly associated variant explains the vast majority of phenotypic variation and accurately differentiates winter from spring types

  hedin faba leaf accessions bionano pacbio rna-seq

• TP53 engagement with the genome occurs in distinct local chromatin environments via pioneer factor activity.

  PMID 25391375 · PMC4315292 · Genome research · 2015 · 8 claims · 8 setups

  Has reproduction · 80

  TP53 binding events fall into three distinct categories defined by the local chromatin environment: TSS (H3K4me3+), enhancer (H3K4me1+/H3K4me3-), and distal (H3K4me1-/H3K4me3-) peaks.

  imr90 hct116 chip-seq rna-seq atac-seq

• Long non-coding RNA LINC00607 epigenetically regulates endothelial TSPAN18 to promote hypoxia-induced thromboinflammation.

  PMID 41581880 · PMC12992942 · The Journal of biological chemistry · 2026 · 8 claims · 8 setups

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  LINC00607 is a hypoxia-inducible, endothelial-enriched lncRNA that positively regulates TSPAN18 expression

  huvecs rna-seq gro-seq atac-seq

• Histone hyperacetylation disrupts core gene regulatory architecture in rhabdomyosarcoma.

  PMID 31784732 · PMC6886578 · Nature genetics · 2019 · 8 claims · 8 setups

  Has reproduction · 58

  SOX8 is a previously unrecognized core regulatory TF in FP-RMS, co-localizing with other CR TFs at SEs and essential for tumor cell growth

  rms rh4 h3k27ac pooled chip-seq

• Comparative multi-omic analysis reveals conserved and derived mechanisms of fin and limb regeneration.

  PMID 41571662 · PMC12923738 · Nature communications · 2026 · 8 claims · 8 setups

  Full-text index only

  Fin and limb regeneration share conserved proximal and distal blastema territory markers, DNA damage repair activation, hif1a-mediated hypoxia response, and sequential pro-/anti-inflammatory gene programs.

  polypterus axolotl zebrafish regenerating single-nucleus spatial single-cell