Experiments
Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).
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Decoding unchanged transcriptome of Alzheimer's disease reveals an NCAM1 mRNA switch as a potential biomarker.
PMID 42006342 · PMC13090632 · iScience · 2026 · 8 claims · 7 setups
Most genes are gene-level non-differentially expressed (nDEGs) in AD but nDEGs are strongly associated with neuronal function pathways
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Spatial perturb-seq: single-cell functional genomics within intact tissue architecture.
PMID 41723140 · PMC13035813 · Nature communications · 2026 · 8 claims · 8 setups
Spatial Perturb-Seq simultaneously measures whole transcriptome (cell type), CRISPR barcodes (perturbation), spatial coordinates, and cell-cell interactions through a single Stereo-seq and/or Xenium run.
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Spatiotemporal transcriptomic profiling reveals upregulation of glycolysis pathway genes before overt tauopathy in the PS19 mouse model.
PMID 41688738 · PMC12992590 · Experimental & molecular medicine · 2026 · 7 claims · 7 setups
Pgk1, a glycolytic hub gene, is upregulated in the CA3 hippocampal subregion at 2 months of age, preceding detectable tau tangle pathology, and its expression correlates with tangle severity.
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Has reproduction · 84
Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology.
PMID 35013236 · PMC8748982 · Nature communications · 2022 · 8 claims · 8 setups
Aβ (APP/PS1) and Tau (MAPT P301S) pathology induce distinct but overlapping astrocyte translatome signatures